Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IFNGR1"”.
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CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
… a single-pass heterodimeric receptor composed of IFNGR1 and IFNGR2. While the IFN-γ signal transduction pathway is well studied, the cell surface regulation of the IFNGR is less well characterized. To gain a better understanding of the ligand-independent regulation of cell surface IFNGR, I …
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
… conditional loss of the IFNg receptor: Ifngr1f/f mice) in different tissues have been generated and used to explore the role of this cytokine in initiating the anti-Listeria response.</p><p>Whereas Ifngr1f/f mice displayed normal cellular levels of IFNGR1 and normal resistance to …
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Cellular Immune Response And Gene Expression Profiling In Crohn's Dise
… in cd and upregulated in uc or viceversa. The ifngr1 gene, which encodes the ligand-binding chain of the ifn-gamma receptor, was found to be downregulated in 2/2(100%) of cd patients, but not in uc patients. It is known that defects in ifngr1 are a cause of atypical mycobacterial infection and …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… impact IFNγ receptor subunit 1 (Ifngr1) localization, mediating IFNγ-induced growth arrest and proinflammatory signaling. Finally, high expression of sphingolipid synthesis genes correlates with poor survival in cancer patients and increasing tumor sphingolipids impairs immune …
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Real Time RT-PCR for Direct Detection of Viable Mycobacterium Avium Subspecies paratuberculosis in Chron's Disease Patients and Association of Map Infection with Downregulation in Interferon-Gamma Receptor (INFG1) Gene in Crohn's Disease Patients
… in the Interferon-gamma receptor gene (IFNGR1) in patients with active Crohn's disease using microarray chip analysis. In this study, measurement of RNA by real time qRT-PCR indicated a possible downregulation in 5/6 CD patients compared to 0/12 controls. The preliminary data suggest …
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Correlation between pro-inflammatory alleles and clinical and laboratory markers of allergy in Xhosa South Africans
… genes relating to TH1 inflammation (IL-12 and IFNGR1) and genes relating to TH2 inflammation (IL-4, IL- 4R, IL-13). Unfortunately, the generalizability of our findings is limited by, amongst others, the selection of pupils from a single school and the use of self-reported end points as markers …