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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 93 for “"IFN-gamma"”.

  1. Inhibition of IFN-[gamma] promoter function by site-specific methylation

    Jones, Brendan T. (Brendan Taber)Massachusetts Institute of Technology2006

    … TH1 cells is characterized by the expression of IFN-y and the silencing of IL-4, while development into TH2 cells is characterized by expression of IL-4 and silencing of IFN-y. Naive helper T cells are hypomethylated at the IFN-y proximal promoter and hypermethylated at the contiguous transcribed …

    mit Repository record

  2. Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition

    McClain, David AlanMassachusetts Institute of Technology2010

    … specific productivity of a recombinant protein (IFN-[gamma]). We used this inhibitor to increase total IFN-[gamma] productivity by 73% in a modified batch culture. With the development of an optimized feed medium, we believe that this CDK2 inhibitor could also be used to increase recombinant …

    mit Repository record

  3. Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis

    Wang, XishengVirginia Tech2006

    … life-threatening toxoplasmic encephalitis (TE). IFN-gamma-dependent, cell mediated immune responses play an essential role in preventing the reactivation of chronic infection of T. gondii in the brain. In my dissertation study, we examined the mechanisms of IFN-gamma-mediated prevention of TE by …

    vt Repository record

  4. Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma

    Laudermilch, Chelsea LeeVirginia Tech2007

    … immune stimulation with the cytokine interferon-gamma (IFN-gamma) can successfully ameliorate some of these defects in the C57BL/6N mouse model. We have observed a reduction in the distal limb malformations syndactyly, polydactyly, and webbing by 47%, 100%, and 63% respectively when IFN-gamma is …

    vt Repository record

  5. Resistenz gegenüber TRAIL-vermittelter Apoptose beim Ewing-Sarkom durch Caspase-8 Mangel - Modulation durch IFN-gamma-

    Klein, Ruth

    … im Western Blot nachvollziehbar. Mittels IFN-gamma Behandlung ließen sich die beiden resistenten Zelllinien A4573 un JR gegenüber TRAIL-vermittelter Apoptose sensibilisieren. Als Ursache für dieses Phänomen zeigte sich die Induktion von Caspase-8 durch IFN-gamma, die ebenfalls auf …

    freiburg-diss Repository record

  6. Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense

    Deng, SiluCreighton University2023

    … and host anti-parasitic defense. Interferon (IFN) family is a group of cytokines that play essential roles in host innate and adaptive immunity against pathogen infections. There are three types of IFNs and all three types of IFN signaling have been observed in intestinal epithelium following …

    creighton Repository record

  7. Dissociated expression of granzyme B and IFN-gamma by T lymphocytes in HIV-1 infected individuals and its implications for Tc1 effector diversity

    Kleen, Thomas OliverUniversität Würzburg

    … local inflammation induced by the secretion of IFN-g. Using assays of single cell resolution, it was studied to what extent these two effector function of CD8+ cells are linked. Granzyme B (GzB) is stored in cytolytic granules of CD8+ cells and its secretion is induced by antigen recognition of …

    wurz-thes Repository record

  8. Unraveling the molecular mechanisms of the class II transactivator, CIITA in skeletal muscle

    Londhe, Priya V.

    … Judy Davie The inflammatory cytokine, interferon gamma, IFN-gamma orchestrates a diverse array of fundamental physiological processes and exhibits complex effects on myogenesis. IFN-gamma also induces the class II transactivator, CIITA, which is a critical mediator of IFN-gamma mediated repression …

    siu-theses Repository record

  9. Role of peroxisome proliferator-activated receptors in mechanisms of rejection in heart transplantation

    Binello, EmanuelaMassachusetts Institute of Technology2004

    … superfamily; two major isoforms, PPARα and PPAR[gamma], are primarily involved in lipid and glucose homeostasis. However, evidence also suggests roles for PPARs in regulating inflammation and atherosclerosis, and prompted investigation into the efficacy of PPAR agonists in parenchymal rejection …

    mit Repository record

  10. Interferon-gamma hemmt die Replikation des Hepatitis-C-Virus

    Schulte, Verena

    … Die Behandlung erfolgt mit einer Kombination aus IFN- und Ribavirin. Mit dieser Therapie wird bei der akuten HCV-Infektion die Eliminierung des Virus erreicht. Allerdings wird die Infektion nur in wenigen Fällen im akuten Stadium erkannt. Meist befinden sich die Patienten mit HCV-Infektion im …

    freiburg-diss Repository record

  11. Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation

    Fu, Yung-KangUniversity of Illinois at Urbana-Champaign2011

    … as the classic phagocyte activator, interferon-gamma (IFN-$\gamma$), in activating polymorphonulear neutrophils (PMN) from pigs, cows, rats and humans to kill Escherichia coli and secrete superoxide anion (O$\sb2\sp-$) after stimulation with phorbol myristate acetate (PMA). GH, as well as its …

    uiuc Repository record

  12. Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF

    Rutherford, Mark StephenUniversity of Illinois at Urbana-Champaign2011

    … or produce IL-6 and LTC$\sb4$ in response to IFN-$\gamma$ and LPS. CSF-1-derived BMDM secreted more TNF-$\alpha$ and PGE$\sb2$ at early stages of culture than did GM-CSF-derived BMDM and required only LPS stimulation to produce NO$\sb2\sp-$. In contrast, GM-CSF-derived BMDM secreted …

    uiuc Repository record

  13. Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells

    Baldeon, Manuel EduardoUniversity of Illinois at Urbana-Champaign2015

    Conclusions. Interferon-$\gamma,$ but not IFN-$\alpha,$ has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic …

    uiuc Repository record

  14. The macrophage activating properties of growth hormone in vitro and in vivo: Comparison to interferon-gamma (IF N-gamma)

    Edwards, Carl Keith, IIIUniversity of Illinois at Urbana-Champaign2011

    … of activated M$\Phi$. To date, Interferon-$\gamma$ (IFN-$\gamma$), a classically defined macrophage activating factor (MAF), has been the most completely characterized substance both in vitro and in vivo known to be produced by mammalian cells that augments the production of reactive oxygen …

    uiuc Repository record

  15. Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain

    윤, 희정2011

    … by lipopolysaccharides (LPS), and interferon-gamma (IFN-gamma). We previously reported that gangliosides, membrane components of brain cells, especially neurons, can activate brain glial cells in vitro, thus could play roles in brain physiology and pathology. In this study, I tested whether …

    ajou Repository record

  16. HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines

    Jaime-Ramirez, Alena CristinaThe Ohio State University2013

    … Importantly NK cells express the Fcgamma receptor IIIa (FcgammaRIIIa) and various cytokine receptors, which can be activated upon encountering antibody-coated targets and cytokines in the tumor microenvironment. Previous work from our group reported a significant association between …

    ohiolink Repository record

  17. Die Bedeutung von Interferon alpha und Interferon gamma auf den Verlauf der Marekschen Krankheit beim Haushuhn

    Harlin, OlofLudwig-Maximilians-Universität

    … features they can be divided into type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Type I plays an important role during the early phase of viral infections, while IFN-gamma has a prominent role later during the infection through its immunmodulatory functions. In this …

    lmu-germany Repository record

  18. Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts

    Roberts, Wendy NiedelmanMassachusetts Institute of Technology2013

    … infection and ensure transmission. Interferon-gamma (IFNγ) activation of non-immune cells is crucial for host defense against Toxoplasma. In murine cells, interferon-inducible immune-related GTPases (IRGs) are essential to the IFN[gamma] response because they disrupt the parasitophorous vacuole …

    mit Repository record

  19. Immune-Mediated Mechanisms of Phthisical and Non-Phthisical Intraocular Tumor Rejection

    Coursey, Terry Glenn, II2011

    … last aim sought to determine the mechanisms of IFN-gamma-independent tumor rejection. Although phthisically-rejected Ad5E1 tumors were not rejected when transplanted into the eyes of IFN-gamma KO mice, they were rejected following subcutaneous transplantation (SC). Thus, outside of the eye, …

    utswmed Repository record

  20. Immuno-modulatory functions of CD1d-restricted natural killer T cells

    Berntman, EmmaEmma Berntman, Department of Experimental Medical Science2006

    … of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust cytokine burst is believed to give NKT cells the capacity to act as a link between innate and adaptive immunity. NKT cells are involved in a cohort of diverse immunological situations, including …

    lund Repository record

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