Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"IFN-I"”.
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The role of the type-I interferon response in the aggregation of tau protein
… to the development of neurodegenerative disease. IFN-Is are soluble cytokines produced in the innate immune response which induce an antiviral transcriptional state via the regulation of several thousand ISGs. Activation of the IFN-I response is observed in the brain in AD and with age. The role …
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Role of type I interferon in pulmonary inflammation and fibrosis
… have revealed elevated type I interferon (IFN-I) pathway activity in autoimmune patients with ILD compared to those without pulmonary involvement, with IFN-I levels positively correlating with disease severity, suggesting a potential pathogenic role in lung disease progression. However, …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of care. However, the mechanisms that mediate the IFN-I-stimulated immune responses …
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Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
… virus (IAV) infection. IAV induced interferons (IFN) play a crucial role in antiviral immunity. However, recent reports have indicated that influenza-induced IFN-I and IFN- γ signaling suppress innate antibacterial immunity by distinct mechanisms, thereby increasing host susceptibility to …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus (SLE), a prototypic systemic humoral autoimmune disease. However, the cellular events that stimulate the development of humoral autoimmunity as a result of pDC …
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Interferon-Dependent Mechanisms of Disease Pathogenesis in Respiratory Syncytial Virus Infection
… antiviral activity of interferon type I (IFN I) and at the same time its paradoxical disease-enhancing properties which have been suggested in recent studies of human infections or experimental animal models. We have also shown that an important component of RSV-mediated pathogenesis is …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
… trigger the production of type-I interferon (IFN-I), which is essential to establish antiviral innate immunity, allowing for the clearance of the offending organism. This process is tightly controlled by post-translational modifications (PTMs), like unanchored (or free) polyubiquitin …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… which amplifies tumor type one interferon (IFN-I) signaling that mediates resistance. Across human and mouse tumors, elevated interferon (IFN) signaling in cancer cells is associated with distinct epigenetic features that predict poor CD8 T cell infiltration. This includes increased …
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Subversion of innate antiviral immunity by SARS-CoV-2: An example from the study of nonstructural protein 16.
… mutant is more sensitive to type I interferon (IFN-I) in vitro. Furthermore, silencing IFIT1 or IFIT3, IFN-stimulated genes that sense a lack of 2’-O methylation, partially restores fitness to the NSP16 mutant. Conversely, overexpressing IFIT1 either alone or in combination with IFIT3 attenuates …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… organelles, antagonism of interferon type I (IFN-I) responses, and NLRP3 inflammasome activation, a major factor of severe COVID-19. Here, I review the most recent published findings regarding the multiple roles of nsp6 in promoting SARS-CoV-2 replication and investigate further the effect of …
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The Role of LIFR Signaling in Innate Immunity
… abnormal activation of type I interferon (IFN-I) signaling in BM monocytes, which is accompanied by an increased activation phenotype and altered transcriptional state in homeostasis. Additionally, we observed that LIFR is required to limit anomalous BM HSC proliferation. Yet, upon …
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Developing improved challenge viruses for macaque models of HIV-1 infection
… of SHIVs to resist the type-I interferon (IFN-I) response, an important component of innate immunity to viruses. Pathogenic SHIVs that have been adapted by macaque-passage were highly resistant to treatment with IFN-I compared to SHIVs encoding circulating HIV-1 Envs. Both replication …
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Exploring antiviral strategies: From innate immunity modulation to viral proteins targeting
… driven principally by type I Interferon (IFN-I). On the one side, when cytosolic DNA is detected cGAS produces cyclic GMP-AMP (2’3’cGAMP) that directly binds STING determining TBK1 phosphorylation (pTBK1) and hence transcription of IFN-I. On the other side, when the RIG-I pathway is …
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Elucidating Mechanisms of Immunity to Nipah Virus Infection through Generation of Attenuated Viruses and a Single-Cycle Vectored Vaccine
… multiple molecules in the type-I interferon (IFN-I) induction and response pathways to modulate the host innate immune response to NiV infection. Previously, ferrets infected with a recombinant NiV (rNiV) lacking V survived an otherwise lethal NiV challenge via an unknown mechanism. Mutation …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… tumor cell-derived type-I-interferon (IFN-I) production in regressor tumors was driving the ISG+ DC state. Ablation of tumor cell-derived IFN-I in regressor tumors led to complete loss of anti-tumor T-cell responses in mice lacking DC1. Conversely, addition of IFNβ to progressor tumors …
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New Roles for Mitochondria in Shaping Antiviral and Stress Responses
… apoptosis and type I interferon signaling (IFN-I). While apoptosis and IFN-I mediated by Mitochondrial AntiViral Signaling (MAVS) are well-established defenses, new dimensions of mitochondrial biology are emerging as battlefronts during viral infection. Increasingly, it has become apparent …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… of enhanced upregulation of type I interferon (IFN-I) response genes at day 1 post-vaccination. Furthermore, flow cytometric analysis of peripheral blood mononuclear cells (PBMCs) collected 6-10 days post-vaccination revealed that long-lasting antibody responses to H1N1 antigen positively …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… abolished the induction of type I interferon (IFN-I) and other pro-inflammatory cytokines by RSV. Genome-wide expression profiling in the lung showed that the vast majority of RSV-induced genes depended on MAVS. Although Myd88 deficiency did not affect most RSVinduced genes, mice lacking both …
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Characterization of cholesterol 25-hydroxylase expression in human macrophages
… connection between type I interferon (IFN-I) and lipid metabolism. Moreover, the details of this connection appear to differ in mouse and human cells. Nevertheless, the molecular basis for the induction of CH25H in humans is not known. Objective Elucidation of signaling and …
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… the role of specific type I interferons (IFN-α and IFN-β), cytokines known for their antiviral and immunomodulatory functions, in virus infection and PAMPs (pathogen-associated molecular patterns) mediated inflammatory responses. To study this, we generated unique knockout (KO) mice of …
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