Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 279 for “"IFN-γ"”.
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
Interferon-gamma (IFN-γ) is a major cytokine that is critical for host resistance to a broad range of intracellular pathogens. Production of IFN-γ by Natural Killer (NK) and T cells is initiated by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as proinflammatory, recent findings highlight a paradoxical protective role by inhibiting Th17 differentiation. In this thesis, we explored how IFN-γ, through its regulation of inducible nitric oxide synthase (iNOS) and …
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Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
… ist die Parasiten-vermittelte Inhibierung der IFN-γ-induzierten MHC Klasse II Expression. In dieser Arbeit konnte gezeigt werden, daß lebende T. gondii die IFN-γ-induzierte MHC Klasse II Expression in der Monocyten/Makrophagen Zellinie RAW 264.7 inhibieren. Weitergehend zeigte sich, daß T. …
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IFN-γ-vermittelte Infektabwehr von <i>Toxoplasma gondii</i> in murinen Skelettmuskelzellen <i>in vitro</i>
… die Wirkung der proinflammatorischen Zytokine IFN-γ und TNF, die eine zentrale Rolle bei der Parasitenabwehr und Stadiendifferenzierung spielen, auf die Parasitenentwicklung in Skelettmuskulatur untersucht. Für die Analysen auf zellulärer Ebene wurden sowohl permanente C2C12-Myoblasten als auch …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… serovar Typhimurium and Toxoplasma gondii. IFN-γ is a cytokine that functions in both the innate and the adaptive immune responses. IFN-γ is mainly secreted by T cells and natural killer (NK) cells and activates macrophages, promotes antigen presentation and enhances antiviral and …
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Changes in Pancreatic and Jejunal Histopatholgy and Serum IFN-γ, TNF-α Levels in Type 1 Diabetes: Role of Chloroform Methanol Soluble Gliadin Proteins
… changes in jejunal histopathology and sera IFN-γ, TNF-α cytokine concentration in type 1 diabetes, induced by GSLEE. A decrease in jejunal CD4+ and γδ TCR + cell counts and inflammatory cell infiltrate were observed due to presence of CM soluble GSLEE in the HC diet, although this decrease …
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The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… as CD146+CCR5+ T cells, co-expressing IL-17A and IFN-γ. We found that the inducible T-cell costimulator (ICOS), which has been reported to be important for human Th17 differentiation in vitro, is critical for the development of this nonconventional T Helper 1 (Th1*)-polarized CD146+CCR5+ …
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Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
… virus (IAV) infection. IAV induced interferons (IFN) play a crucial role in antiviral immunity. However, recent reports have indicated that influenza-induced IFN-I and IFN- γ signaling suppress innate antibacterial immunity by distinct mechanisms, thereby increasing host susceptibility to …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… in melanocytes. Here, I studied whether IFN-γ affects melanogenesis, and if so, what is the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression and activity and TRP-1, TRP-2 …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
Interferon-gamma (IFN-γ) is a key cytokine that orchestrates immune defence through its antiviral, antimicrobial, and antitumour activities. Despite its central role in immune regulation, its broader therapeutic application has been constrained by an incomplete understanding of how subtle …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for haematological …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for haematological …
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Investigation of the TNF superfamily of ligands as potential therapeutic targets in inflammatory bowel diseases
… of the thesis, various cytokines, particularly IFN-γ and TNF-α, produced by activated immune cells, play a significant role in the pathogenesis of IBD. TNF-α blocking antibodies, known collectively as anti-TNFs, revolutionised the treatment of IBD in the mid to late 1990s; however, about 60% of …
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Tumor Antigens Revealed by Exome Seqeuncing Drive Editing of Tumor Immunogenicity
… important roles for lymphocytes and type I: IFN-α/β) and type II: IFN-γ) interferons in cancer immunoediting. In the present work, we confirmed the role of IFN-γ in sculpting tumor immunogenicity and provide evidence that antigens expressed by tumors drive the destructive or sculpting actions …
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A Search for the Counter-Immune Mechanisms of Mycobacterium Tuberculosis
… and the human immune response. The cytokine IFN-γ triggers macrophage production of bactericidal nitric oxide by inducible nitric oxide synthase (NOS2) and is essential for mammalian control of Mtb infection. Mice lacking NOS2 are unable to control replication of Mtb and rapidly succumb to …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… gene expression (CAGE) transcriptomics on IFN-γ stimulated (classically activated) and IL-4/IL-13 stimulated (alternatively activated) mouse macrophages, identifying 151 differentially expressed lncRNAs following Mtb infection. We validated the top 11 differentially expressed lncRNAs and …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… Studies have shown that interferon-gamma (IFN-γ), a pro-tumorigenic cytokine in CM, induces the expression of programmed death-ligand 1 (PD-L1), leading to the escape of melanoma cells from immunosurveillance. Our previous study suggests that neuronal nitric oxide synthase (nNOS)-mediated …
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Inactivation of the JAK-STAT Pathway
… of downregulation. After interferon-γ (IFN-γ) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 minutes, remained for 2-2.5 hours and activated molecules disappeared by 4 hours. In the absence of continued signaling from the IFN-γ …
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Investigating cytokine responses to different strains of Mycobacterium tuberculosis
… CD4+ T cell adaptive cytokine responses (IFN-γ, IL-22 and IL-17) in blood from human volunteers with prior exposure to Mtb, when stimulated with different strains within the MTBC, using a whole blood assay, flow cytometry and enzyme-linked immunosorbent assay (ELISA). My results indicate …
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