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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 34 for “"IFN-β"”.

  1. Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein

    Randall, CrystalUniversity of Illinois at Urbana-Champaign2013

    … Factor-α (TNF-α) and anti-viral interferon- β (IFN-β) cytokines are highly expressed in MCV lesions and surrounding tissue. Despite the expression of pro-inflammatory factors, MCV infections cause little inflammation. Not surprisingly, MCV encodes immunomodulatory proteins such as the MC159 …

    uiuc Repository record

  2. The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein

    Park, Jang WonThe University of Texas at Austin2009

    … thirds of the protein, suppresses interferon-β (IFN-β) synthesis in virus-infected cells by unknown mechanism(s). The induced IFN-β mediates innate immunity. To elucidate the mechanism by which the NS1B effector domain suppresses the production of IFN-β, we identified cellular proteins that …

    texas Repository record

  3. BV-2 미세아교세포에서 PGE2 에 의한 LPS 유도 IFN-β생성 조절

    이, 태구2011

    … 면역반응과 염증반응을 유발하는 것으로 알려져 있다. 면역 반응 시 생성이 증가되는IFN-β 는 항 바이러스성 물질로 잘 알려져 있으며 최근에는 다발성경화증 (multiple sclerosis) 과 같은 염증성질환의 치료제로 사용되고 있다. 일련의 보고에서 대표적인 proinflammatory mediator 로 잘 알려진 PGE2 가 IFN-β 의 생성을 억제하는 작용이 있는 것으로 보고된 바가 있지만 그 작용 기전에 대해서는 아직 정확히 밝혀진 바가 없다. 본 연구는 PGE2 에 의한 LPS 유도 IFN-β생성 …

    ajou Repository record

  4. Examination of type I IFN mediated regulation of the post-transcriptional antiviral response

    Burke, James Daniel2015

    Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus …

    toronto-retro Repository record

  5. Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains

    Lo, Modou Moustapha2012

    … Wirtsspezies erklären könnte. Interferon-β (IFN-β) ist eine zentrale Komponente des angeborenen Immunantwort. Daher wurde die IFN-β-antagonistische Funktion des NSs-Proteins von RVFV Isolaten unterschiedlicher Herkunft (Säugetiere, Menschen und Insekten) nach Klonierung und Sequenzierung des …

    goettingen Repository record

  6. Tolerance and Immunity: Opposite Outcomes of Microbial Antigen Stimulation

    Eroukhmanoff, LenaSection for Immunology, Lund University2010

    … II, bone marrow-derived dendritic cells from IFN-β-/- mice were used to study the role of IFN-β in TLR2-mediated induction of iNOS. We demonstrate that the TLR2 ligands LTA and Pam3Cys induce the expression of iNOS in an IFN-β dependent manner. Furthermore, iNOS activity induced by these …

    lund Repository record

  7. A Study of Human Coronavirus NL63: Characterization of Virus Replication, Targeting of Papain-Like Protease 2 by Antivirals and Probing Virus Mediated Innate Immune Antagonism

    Banach, Bridget

    … HCoV-NL63 mediated antagonism of interferon-β (IFN-β) induction. I showed that HCoV-NL63 infection of bronchial epithelial cells results in a small, but measurable release of IFN-β by enzyme linked immunosorbent assay (ELISA). I confirmed that HCoV-NL63 PLP2 is an IFN-β antagonist, and abrogates …

    loyola-thes Repository record

  8. Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif

    Weber, Sarah2015

    … such as apoptosis and activation of interferon (IFN). Presumably, MC159 and MC160 bind to host DED-containing proteins as a means to prevent the formation of innate immune signaling complexes. The RxDL motif is conserved among several host and viral DED-containing proteins and has previously been …

    shu-thes Repository record

  9. The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes

    Calame, Daniel2014

    … of protective cytokines such as TNF-α, IFN-γ and IL-6. As Type 1 IFN impedes the host response to Lm through the promotion of splenocyte death, we examined the effect of C5a and C5aR on type 1 IFN expression <em>in vivo </em>and <em>in vitro</em>. Serum levels of IFN-α and IFN-β are …

    uthsc Repository record

  10. Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells

    이, 광민2014

    … specific ligand)-induced expression ofICAM-1 and IFN-β,which was mediated suppression of NF-kB or IFN-β transcriptional activity, respectively. These data indicate TRIF-dependent signaling pathway is also blocked by IBC. Taken together, our data suggest that IBC inhibits LPS-induced ICAM-1 …

    ajou Repository record

  11. Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals

    Head, Jennifer 1980-The University of Texas Medical Branch at Galveston2016

    … PKR and general transcription shutoff including IFN-β mRNA synthesis. Currently, no effective measures have been developed to prevent or treat RVFV disease and very little is understood about what takes place during the initial stages of RVFV infection. The objective of this series of studies was …

    utmb Repository record

  12. Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems

    Williams, Evan Peter2023

    … mRNA levels of only CCL5, CXCL10, CXCL11, IDO1, IFNB1, IRF7, and TLR3 we increased during infection of each viruses. The measurement of CCL5, CXCL10, CXCL11, IDO, and IFN-β secreted protein levels in the same HLMVEC donor during infection confirmed gene expression findings. The study of host …

    tenn-hsc Repository record

  13. Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus

    Zhang, QingzhanUniversity of Illinois at Urbana-Champaign2018

    … to viral infections. Type I interferons (IFN-α/β) are the major components of the innate immune system, and in turn many viruses have evolved to modulate the host interferon responses. In the present study, the PEDV IFN antagonism was investigated. We found that IFN-β production was …

    uiuc Repository record

  14. Developing a diagnostic assay for Pneumocystis jirovecii pneumonia and investigating the interaction of Pneumocystis murina and respiratory syncytial virus during co-infection in mice

    Hlagala, ElizabethDepartment of Pathology2025

    … cytokines IL-1β, IL-12 p40, IL12-p70, and IFN γ and serum IgM and IgG levels were elevated in the P. murina group compared to the RSV group. Interestingly, the levels of IFN-β were significantly reduced in the coinfected group compared to the RSV group. The detection of Kex1 in infected …

    cape-town Repository record

  15. Role of TRB3 in Glucose Enhancing Effect on LPS-induced NO Production

    박, 혜시2015

    … 경로의 specific agonist를 이용하여 iNOS, NO, NF-κB 그리고 IFN-β의 발현에 미치는 TRB3의 영향을 확인 하였다. 선행연구결과와 동일하게 고포도당 조건에서 LPS를 통한 NO생성은 증폭이 되고, 저포도당 조건에서는 감소하는 작용을 보였다. 이때 TRB3의 발현은 저포도당 조건에서 증가하였다. 염증반응을 매개하는 NO생성 조절인자인 iNOS 역시 포도당의 농도에 영향을 받는 것을 확인하였다. TRB3의 과발현 유도 시 고포도당 조건임에도 불구하고 iNOS발현이 감소하였으며 siRNA에 의한 …

    ajou Repository record

  16. Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus

    Murugathasan, Mayoorey2024

    … the role of specific type I interferons (IFN-α and IFN-β), cytokines known for their antiviral and immunomodulatory functions, in virus infection and PAMPs (pathogen-associated molecular patterns) mediated inflammatory responses. To study this, we generated unique knockout (KO) mice of …

    york Repository record

  17. Antiviral activity of 3D8 single chain Fv against RNA virus infection

    전, 혜령2012

    … viral RNA replication level without involving IFN-β induction. The antiviral mechanism of action is inhibition of propagating viral RNA transcripts by binding or degrading on viral RNA due to RNase activity of 3D8 scFv itself.

    ajou Repository record

  18. Molecular Mechanism of MDA5 RNA Sensing in Innate Immunity and Disease Pathogenesis

    Singh, RahulUniversity of Cambridge2023

    … stabilises MDA5-dsRNA complexes, increases IFN-β transcription, and disrupts signal transduction. Cryo-electron microscopy structures of wild-type (WT) and M854K MDA5-dsRNA filaments provided detailed insights into how the M854K mutation hinders conformational changes necessary for ATP …

    cambridge Repository record

  19. Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods

    Tripathi, JasmineUniversité d'Ottawa / University of Ottawa2024

    … while the MO model demonstrated activated IL-1β, IFN-β and TNF signalling, and leukocyte chemotaxis. Likewise, both models demonstrated transcriptomic evidence of mitochondrial dysfunction including downregulated mitochondrial ATP synthesis, oxidative phosphorylation and NADH synthesis pathways. …

    ottawa-retro Repository record

  20. Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation

    Pelicano Da Cunha Branco Da Costa, CatarinaUniversity of Cambridge2025

    … FOXA1/FOXA2, promoting expression of interferon (IFN)-α/γ response genes. Inhibition of IFN-β was sufficient to attenuate iCAF-derived paracrine signalling and suppress STAT1 phosphorylation. In contrast, myCAFs promoted SOX2 upregulation in cancer cells through direct cell-cell contact. SOX2 was …

    cambridge Repository record

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