Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IFN signalling"”.
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Oleoylethanolamide and palmitoylethanolamide synergize with IFNβ to potentiate apoptosis and PD-L1 induction in SH-SY5Y neuroblastoma cells
… of existing treatments. Type I interferons (IFNs), particularly IFNβ, are cytokines with well-characterized antiviral and anti-proliferative actions and documented capacity to trigger apoptosis in tumour cells, including NB. In this study, we investigated whether OEA and PEA could modulate …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
… that NoV employs strategies to regulate type-I IFN signalling pathways by inhibiting IRF3 activation by phosphorylation. This thesis also aimed to use the MNV cell culture model to assess the inhibitory effect of four recently identified non-nucleoside inhibitors. The compounds represent early …
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A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
… four proteins that directly target interferon (IFN)-induced signalling. Here we report the first function of the uncharacterised, 60 aa 018 protein from VACV strain western reserve. The 018 protein was expressed early during infection and found to potently inhibit type I and type II IFN-induced …
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CHARACTERISATION OF A NOVEL SMALL MOLECULE INHIBITOR FOR IMMUNE ACTIVATION IN TRIPLE NEGATIVE BREAST CANCER
… gene and protein expression of Type I/III IFNs in TNBC cell lines. This signalling is dependent on the RIG/MAVS cytosolic RNA-sensing pathway, and is possibly triggered by increased cytosolic localisation of mitochondrial dsRNA. Using a 3D vascularised TNBC model, CHL-4 treatment increased …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… signatures and activation of the Interferon (IFN) signaling pathway. Notably, IFN signaling activation was a distinguishing feature of both quiescent and proliferating blasts and was predictive of clinical response to standard chemotherapy in AML patients. To investigate the contribution of …
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis
… on restoration of HIV-suppressed inflammatory signalling pathways by ARV therapy. (2) Regarding the clinical cohort, a sample size of > 42 participants per characteristic-matched comparison class provides > 95% power to detect a two-fold change with 99% confidence. Cases exhibited known TB-IRIS …