Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"IFNγ"”.
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… degradation in astrocytes chronically exposed to IFNγ, an HIV-associated CNS immune activator. We show that HO-1 protein loss in HIV-infected brain correlates with induction of IFNγ-inducible immunoproteasome subunits and is accompanied by increased HO-1 RNA; we also identified increased astrocyte …
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Tuberculosis and genes of the IL12/IL23/IFNγ pathway: Exploring functional significance of novel mutations in the IL12p40 promoter
… phenotype was investigated by measurement of IFNγ, TNFα and IL12p70 cytokine levels and IL12βR1 receptor expression. While distinct patterns of cytokine responses were seen, these did not predict genotype. These results show that the IL12p40 gene promoter is highly conserved and sequence …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
<p>The JAK-STAT pathway is a major signaling pathway involved in many biological processes including proliferation, apoptosis, and differentiation. Aberrant expression of STATs has been reported in multiple human cancers and murine mouse models of tumorigenesis. Previous studies from our lab and …
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Dynamic Assessment of Nk Cell Interactions With Pediatric Tumor Cells to Predict Response to Immunotherapy
… that our expanded NK cells secret 20 times more IFNγ than resting NK cells. Opposing effects have been reported for IFNγ on tumor sensitivity to NK-mediated lysis. Therefore, another aim of my study was to evaluate the effect of IFNγ on tumor sensitivity to NK cell mediated lysis, tumor …
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Immunotherapy against malignant brain tumors - of mice and men
… we demonstrate the establishment of a GM-CSF and IFNγ based immunotherapy in the mouse glioma model, GL261. Mice with intracranial gliomas were immunized intraperitoneally with GL261 cell genetically modified to produce GM-CSF combined with recombinant IFNγ. This combination synergistically …
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… and cytokine production, including IL-4 and IFNγ. However, our studies have shown that two doses of α-GalCer administered intranasally by the intranasal route leads to reactivation of NKT cells and improved adaptive immune responses after each subsequent dose. I therefore investigated the …
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Characterisation of Mucosal Associated Invariant T cells function and metabolism in health and obesity
… IL-17 production, accompanied by impaired IFNγ expression. As of now, very little is known about the control of MAIT cell function, therefore more research is required to understand their biology in order to identify the altered process, which leads to their dysfunction in obesity. …
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Combined chemotherapy and immunotherapy against experimental malignant brain tumors
… cytokines such as interferon-gamma (IFNγ), interleukin-7 (IL-7) and granulocyte macrophage-colony stimulating factor (GM-CSF). In the N32 rat glioma model there is a synergistic therapeutic effect when combining immunization with IFNγ- and- IL7-producing tumor cells and this coincides …
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Development of an IL12 Prodrug to Treat Solid Tumors with Minimal Toxicity
… intratumor CD8+ T cells that produce IFNγ after direct binding of the prodrug to cell surface IL12 receptor complexes. Pro-IL12 also worked in combination with TKI and ICB to achieve even more potent tumor control. In a follow up study, I propose that a higher dose of pro-IL12 might …
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Evaluation of Weaning Stress in Beef Calves
… were detected in the interferon gamma (IFNγ) production and weight gain between the heifers on alfalfa and fescue. In study 3, effects of two-stage (fenceline) and abrupt weaning were compared. Calf weights, immune cell function, antibody production, blood glucose concentrations, fecal …
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Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… inflammatory responses with an increase in IL17- IFNγ- CD4+ T cells. Notably, we found that primary and dominant immune responses in hnRNPI knockout mice were significant increases in regulatory T cells and IL17- IFNγ- CD4+ T cells in the colon. Collectively, these results demonstrated that medium …
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Effective Strategies for Preventing and Mitigating Emerging Viruses
… full protection from wildtype CHIK disease. Our IFNγ-expressing vaccine showed the most significant attenuation of viral replication. To understand the underlying mechanism, we identified three IFNγ-regulated antiviral genes (Gbp1/2 and Ido1) that were highly upregulated in 3T3 mouse fibroblasts …
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Metodika ELISpot a predikce rejekce po transplantaci ledviny.
… (frekvence) buněk produkujících interferon gama (IFNγ) před transplantací umožňují identifikovat pacienty s vysokým rizikem akutní celulární rejekce a zároveň predikovat dlouhodobé přežívání štěpu. V této práci jsme z periferní krve pacientů odebrané před transplantací stanovovali pomocí metody …
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Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide
… e Ionomicina de parte destes pacientes com AR (IFNγ, IL-17A, IL-6 e IL-22). O LPSF/TM17 inibiu significativamente a produção de IFNγ na concentração de 100μM e de IL-17A e IL-22 nas concentrações de 1, 10 e 100 μM (p<0,05). Este estudo foi pioneiro em associar os níveis de IL-22 com a gravidade …
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Equine Protozoal Myeloencephalitis: investigating immunopathogenesis and treatment efficacy in mouse models and clinically affected horses
… this dissertation, the role of T-lymphocytes and IFNγ was further elucidated. It was determined that IFNγ production is essential for T-lymphocytes to offer protection against S. neurona induced encephalitis, in immune compromised mice. Another factor hindering prognosis of EPM affected horses is …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… accompanied with a decrease in the production of IFNγ by T cells ex-vivo. To determine the mechanisms of reduced EAE, we tested the effects of γSI on TH1 and TH17 differentiation. Culture with γSI reduced the expression of IFNγ and IL-17 without altering T cell activation or proliferation. The …
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Characterisation of Novel Secreted Antiviral Factors to Human Cytomegalovirus
… been established for the antiviral cytokines IFNγ and TNFα during HCMV infection, the contribution of soluble factors to viral control remains poorly understood. In this thesis I demonstrate that the complement of secreted factors (secretomes) produced by immune cells co-cultured with …
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… response to elevated levels of interferon-gamma (IFNγ) in the lung tdLN. Administration of IFNγ-blocking antibody could counter the tissue-specific enrichment in IFNγ, repolarize Tregs and restore cytotoxic T cell responses against lung cancer. Next, we examined longitudinal changes in anti-tumor …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… to apoptosis induced by immune cells-derived IFNγ in response to bacterial invasion. To define SOCS1 IEC-intrinsic role in the epithelium integrity and renewal, and for confirming that SOCS1 deficiency sensitizes IECs to IFNγ-driven cell death, crypt-derived colonoid populations from the WT, …
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Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
… 12-myristate 13-acetate (PMA), interferon γ (IFNγ) and lipopolysaccharide (LPS). The GR was shown to be required for the GC induction and modulation of CCL20 mRNA expression. Using promoter-reporter assays, the results showed that the NFκB binding site was necessary for the activation by the …
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