Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"IFNα"”.
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Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
… and plasmacytoid DCs (pDCs), as the principal IFNα/β producing cells, serve as potential targets for both immune evasion and therapeutic strategies. In order to evaluate the effects of HCV on DC function, we compared phenotypic and functional characteristics of DCs from chronically infected …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… mice. We hypothesized that Type-I interferon (IFNα/β), could be playing a role in this resistance. However, it was found that MYXV treatment did not elicit an IFNα/β response in these glioma lines in vitro or in vivo. Further, engineered ablation of IFNα/β signalling in the glioma in vivo had …
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Treatment of Systemic Lupus Erythematosus by Nutrition and Dendritic Cell Targeting
… the initiation of lupus development by producing IFNα. However, we demonstrated that although pDCs produced a large amount of IFNα during disease initiation, those from late-stage lupus mice were found to be defective in producing IFNα, suggesting that pDC-targeted treatments should be performed …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… was reduced in the absence of interferon-α/β: IFNα/β) or IFNγ signaling; Batf3-/- mice lacking CD8α+ dendritic cells: DCs) also showed reduced cross-priming. We examined the ability of draining lymph node: dLN) DCs to process and cross-present soluble HEL to CD8+ T cell hydridomas. DCs isolated …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… cancer cells. The combined treatment of SMC and IFNα induces tumour regression in mice, and this effect is completely abrogated upon treatment with TNFα-neutralizing antibody. The synergistic effects are mediated by tumour cells and by contribution of immune cells, particularly macrophages and …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… receptor that recognises interferons such as IFNα. Interferons (IFNs) are pluripotent, antiviral cytokines that causes antiproliferative effects, primarily through Jak/STAT signalling. The T-cell receptor is an antigenic receptor that recognises antigenically-derived peptides in the context of …
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Sensing of Picornavirus Infections
… reduced in the absence of each sensor, and IFNα; expression reduced in the absence of MDA-5. However, in macrophages EMCV and CVB3 do not grow and we find that the sensing of viruses differs in murine embryonic fibroblasts (MEFs) and HeLa cells in which there is efficient replication. In …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… in UC by use of adenoviral interferon-α (Ad-IFNα/Syn3) in human patients, and poly(I:C) or lentiviral IFNa (LV-IFNa) in mice. To this end, I evaluated the IFN-I enhanced immune response by observing increases in expression of immune cell and checkpoint markers in tumors pre- and post- IFN-I …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… to bunyavirus infection, and show that innate IFNα/β responses are insufficient to protect these essential cells. Exogenous ligands such as Pam3CSK4 may have a use as antiviral agents in cases of bunyavirus encephalitis. Studying the regulation and functions of immunity in the brain may …
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Investigations into novel signalling pathways in the response to viral and bacterial infections
… TLR7 mediated activation of RANTES, IFNβ, IFNα but not NFκB reporter genes. Furthermore, TRAM was shown to co-immunoprecipitate with the TLR7 adaptor molecule MyD88 upon TLR7 activation. This is first time that either IRF3 or TRAM has been shown to play role in TLR7 signalling. The second …
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Probing the Mechanisms Underlying the Regulatory Effects of Cactin in Innate Immune Signalling Pathways
… Cactin negatively regulates IRF7-mediated IFNα induction and affects the protein stability of IRF7. Notably, these inhibitory effects are transcription factor specific as Cactin positively regulates the activation of AP-1 subunit c-Jun, demonstrating that Cactin can differentially regulate …
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Priming of STAT1 and STAT3 for cytokine-triggered degradation by the proteasome upon A2Aadenosine receptor (A2AAR) expression
… of the human A2AAR conferred an ability of IFNα, leptin and a soluble IL- 6 receptor-α/IL-6 (sIL-6Rα/IL-6) trans-signalling complex to promote a time-dependent reduction in the levels of STAT proteins that was entirely due to proteasomal degradation. In terms of functional consequences, …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… monocytes and CD4+ T-cells upon stimulation with IFNα, across five donors. The cell surface proteomes were characterised, and found to be remarkably invariant between donors, whilst the effects of IFN were more variable between donors. IFN stimulation of several proteins was validated by flow …
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Monogenic Defects of the Type I Interferons Signaling Pathway in Humans: Molecular and Clinical Implications
… I describe the first cases of inherited IFN IFNα/b receptor-1 (IFNAR1) deficiency in children who suffered severe complications following vaccination with attenuated viral vaccines but who were otherwise healthy. IFNAR1 is one of the two subunits that form the receptor for type I IFNs, and I …
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Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… despite utilizing the same receptor, intravenous IFNα, but not IFNβ, can reconstitute encephalitic protection. Further, we find that brain microvascular endothelial cells (BMECs) act as a relay for the IFN message between the periphery and the CNS. AAV-mediated ablation of IFN signaling on BMECs …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… the later stages of MV infection. Additionally, IFNα is significantly upregulated in the absence of IFNg in the brain post-MV infection. Thus, compensatory cytokines and high immune cell infiltration may contribute to uncontrolled inflammation and earlier death in CD46+/IFNg-KO neonates. CD46+ …