Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 773 for “"IFN"”.
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Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity
… estrogen may alter the levels and/or response to IFN-g, a prototype Th1 cytokine, that plays a pivotal role in immunity against intracellular infections and in many autoimmune and inflammatory disorders. We found that estrogen treatment tended to upregulate the secretion of IFN-g protein and mRNA …
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The type I IFN of Bos taurus
The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal …
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Cryptosporidium Uses Its Cspv1 Virus to Activate Host Type I IFN Response and Attenuate IFN-Gamma-Mediated Epithelial Anti-Parasitic Defense
… and host anti-parasitic defense. Interferon (IFN) family is a group of cytokines that play essential roles in host innate and adaptive immunity against pathogen infections. There are three types of IFNs and all three types of IFN signaling have been observed in intestinal epithelium following …
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Inhibition of IFN-[gamma] promoter function by site-specific methylation
… TH1 cells is characterized by the expression of IFN-y and the silencing of IL-4, while development into TH2 cells is characterized by expression of IL-4 and silencing of IFN-y. Naive helper T cells are hypomethylated at the IFN-y proximal promoter and hypermethylated at the contiguous transcribed …
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Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition
… specific productivity of a recombinant protein (IFN-[gamma]). We used this inhibitor to increase total IFN-[gamma] productivity by 73% in a modified batch culture. With the development of an optimized feed medium, we believe that this CDK2 inhibitor could also be used to increase recombinant …
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
Interferon-gamma (IFN-γ) is a major cytokine that is critical for host resistance to a broad range of intracellular pathogens. Production of IFN-γ by Natural Killer (NK) and T cells is initiated by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of …
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BV-2 미세아교세포에서 PGE2 에 의한 LPS 유도 IFN-β생성 조절
… 면역반응과 염증반응을 유발하는 것으로 알려져 있다. 면역 반응 시 생성이 증가되는IFN-β 는 항 바이러스성 물질로 잘 알려져 있으며 최근에는 다발성경화증 (multiple sclerosis) 과 같은 염증성질환의 치료제로 사용되고 있다. 일련의 보고에서 대표적인 proinflammatory mediator 로 잘 알려진 PGE2 가 IFN-β 의 생성을 억제하는 작용이 있는 것으로 보고된 바가 있지만 그 작용 기전에 대해서는 아직 정확히 밝혀진 바가 없다. 본 연구는 PGE2 에 의한 LPS 유도 IFN-β생성 …
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Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis
… life-threatening toxoplasmic encephalitis (TE). IFN-gamma-dependent, cell mediated immune responses play an essential role in preventing the reactivation of chronic infection of T. gondii in the brain. In my dissertation study, we examined the mechanisms of IFN-gamma-mediated prevention of TE by …
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Examination of type I IFN mediated regulation of the post-transcriptional antiviral response
Interferons (IFNs) are pleiotropic cytokines that regulate both innate and adaptive immunity. Early post viral infection, there is induction and secretion of IFN-β which alerts nearby cells and primes leukocytes for an immune response. A rapid response is necessary for effective control of virus …
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Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
… Furthermore, treatment with interferon (IFN)α achieves sustained virologic response in approximately 50% of chronically infected individuals. Conventional dendritic cells (cDCs), as the most potent antigen presenting cells, and plasmacytoid DCs (pDCs), as the principal IFNα/β producing …
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IFN-γ Induced Nitric Oxide Leads to the Inhibition of TH17 Differentiation via iNOS
… cytokines such as IL-17. While Interferon-gamma (IFN-γ) is traditionally seen as proinflammatory, recent findings highlight a paradoxical protective role by inhibiting Th17 differentiation. In this thesis, we explored how IFN-γ, through its regulation of inducible nitric oxide synthase (iNOS) and …
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Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
… ist die Parasiten-vermittelte Inhibierung der IFN-γ-induzierten MHC Klasse II Expression. In dieser Arbeit konnte gezeigt werden, daß lebende T. gondii die IFN-γ-induzierte MHC Klasse II Expression in der Monocyten/Makrophagen Zellinie RAW 264.7 inhibieren. Weitergehend zeigte sich, daß T. …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… stimulation with the cytokine interferon-gamma (IFN-gamma) can successfully ameliorate some of these defects in the C57BL/6N mouse model. We have observed a reduction in the distal limb malformations syndactyly, polydactyly, and webbing by 47%, 100%, and 63% respectively when IFN-gamma is given 2 …
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Identification of viral and cellular factors that modulate heterogeneity in IFN induction during influenza infection
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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IFN-γ-vermittelte Infektabwehr von <i>Toxoplasma gondii</i> in murinen Skelettmuskelzellen <i>in vitro</i>
… die Wirkung der proinflammatorischen Zytokine IFN-γ und TNF, die eine zentrale Rolle bei der Parasitenabwehr und Stadiendifferenzierung spielen, auf die Parasitenentwicklung in Skelettmuskulatur untersucht. Für die Analysen auf zellulärer Ebene wurden sowohl permanente C2C12-Myoblasten als auch …
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Resistenz gegenüber TRAIL-vermittelter Apoptose beim Ewing-Sarkom durch Caspase-8 Mangel - Modulation durch IFN-gamma-
… im Western Blot nachvollziehbar. Mittels IFN-gamma Behandlung ließen sich die beiden resistenten Zelllinien A4573 un JR gegenüber TRAIL-vermittelter Apoptose sensibilisieren. Als Ursache für dieses Phänomen zeigte sich die Induktion von Caspase-8 durch IFN-gamma, die ebenfalls auf …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… serovar Typhimurium and Toxoplasma gondii. IFN-γ is a cytokine that functions in both the innate and the adaptive immune responses. IFN-γ is mainly secreted by T cells and natural killer (NK) cells and activates macrophages, promotes antigen presentation and enhances antiviral and …
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The economics of animal welfare: an appraisal of welfare issues ifn the South African poultry industry
Growing consumer awareness of animal welfare has co-evolved with increases in intensive farming, particularly of battery chickens. This rise in consumer awareness recently saw bans on battery farming in parts of Europe. This thesis addresses the difficulties that would follow any similar attempt to …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
Interferon-gamma (IFN-γ) is a key cytokine that orchestrates immune defence through its antiviral, antimicrobial, and antitumour activities. Despite its central role in immune regulation, its broader therapeutic application has been constrained by an incomplete understanding of how subtle …
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