Global ETD Search
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Showing 1 to 8 of 8 for “"IFITM3"”.
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Characterization and Reconstitution of S-Palmitoylated IFITM3 Antiviral Activity
… is interferon-induced transmembrane protein 3 (IFITM3). IFITM3 is a host protein known to play a key role in inhibiting numerous virus infections, including influenza, Dengue, West Nile, HIV and Ebola. It is active in the early stages of infection and interferes with viral fusion and content …
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Chemical Tools for Exploring IFITM3 S-Palmitoylation and Mechanism
… on three conserved Cys residues were crucial for IFITM3 anti-influenza virus activity. However, endogenous levels and site-specific functions of S-palmitoylation on the individual IFITM3 Cys residues were unknown and are addressed in Chapter 2. In collaboration with other members of the Hang …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… or WT. This demonstrated an upregulation of IFITM3, an essential gene in modulating immune function. Based on these findings, we hypothesized that BRCA-deficient HGSOC have increased DNA damage leading to upregulation of IFITM3 and subsequent increase in antigen presentation and T-cell …
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Genetic variation in the IFITM locus and its phenotypic consequences
… to infect host cells. In contrast, IFITM2 and IFITM3 are found in the early and late endosomes, respectively, and are potent inhibitors of viruses that depend on endosomal pathways for infection. I begin this dissertation by providing some background on the biology and function of IFITM …
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USING SINGLE VIRION FUSION ASSAY TO STUDY INFLUENZA VIRUS ENTRY
… mechanism of an influenza antiviral drug, IFITM3. IFITM3 has been shown to be able to stop influenza virus entry at the fusion step, and lead to the failure of infection.
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
… infection as well as lipidated host proteins (IFITM3 and ZAP) involved in cellular resistance to viruses. My thesis work highlights the utility of alkyne lipid reporters for biochemical analysis of lipidated proteins at the host-pathogen interface that will hopefully help other biological …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… level, including LIN28, NANOG, POU5F1 (OCT4), IFITM3 (fragilis), STELLA, PRDM1 (BLIMP1), and C-KIT, indicating their early germline nature. Investigation of neo-oogenesis potential revealed that putative human OSCs were associated rarely with fetal somatic cells in primordial follicle-like …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… of both Interferon Stimulated Genes (IFITM1, IFITM3, STAT1, NFkB) and the antigen presentation pathway (ERAP1, ERAP2, HLA-A and TAP). Overall, the results obtained suggest that HCO organoids may be infected by SARS-CoV-2 and their homeostasis may be significantly altered even following …