Global ETD Search
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Showing 1 to 7 of 7 for “"IFITM1"”.
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Functional study of the IFITM1 gene related to tumor progression of NF1
… 9 2. Primary fibroblast 배양 10 3. 유전자 과발현을 위한 IFITM1 construct 구축 10 4. Total RNA 추출 및 cDNA 합성 12 5. RT-PCR (Reverse Transcription-PCR) 12 6. Western blot analysis 13 7. Ras activation assay 15 8. Cell death assay 15 9. Transfection 15 10. Confocal microscopy 16 Ⅲ. 결과 17 A. 일차배양세포에서의 IFITM1의 …
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Screening and Functional Study of the Genes inducing Malignant Degeneration of Neurofibromatosis Type 1
… we selected 3 genes, TAGLN, SERPINE1, and IFITM1, as the key gene(s) involved in malignant degeneration of NF1 in this patient. Two genes, TAGLN and SERPINE1, showed up-regulation of expression in the tumor cells, while IFITM1 showed down-regulation of expression in the tumor cells. In …
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Characterizing novel molecular regulators of antiviral gene expression
… a subset of ISGs, including the antiviral genes IFITM1 and MX1, after IFN treatment. However, the expression of other ISGs and the overall activation of the IFN responses were unchanged. Using methyl RNA immunoprecipitation and sequencing (meRIP-seq), we found that the transcripts of many ISGs …
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Genetic variation in the IFITM locus and its phenotypic consequences
… exert their broad antiviral role. For example, IFITM1 localises to the plasma membrane and restricts viruses that do not require endocytosis to infect host cells. In contrast, IFITM2 and IFITM3 are found in the early and late endosomes, respectively, and are potent inhibitors of viruses that …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
… ANGPTL7, CD248, CH25H, COL14A1, CXCL12, HSPA6, IFITM1, IL-7, MMP1, MMP13 and TNFSF10. Cisplatin was only able to decrease the expression of 7 genes, however, in combination with curcumin, a total of 9 genes were downregulated. Curcumin was able to work in synergy with cisplatin in order to …
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Can curcumin improve the methotrexate based treatment for rheumatoid arthritis?
… ANGPTL7, CD248, CH25H, COL14A1, CXCL12, CYTL1, IFITM1 and IL7. Curcumin was found to also increase the expression levels of genes associated with anti-inflammatory roles, namely BCAR4, CD274, HSPA6, OTP and RELT. The increased gene expression in samples treated with both MTX and curcumin …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… expression of both Interferon Stimulated Genes (IFITM1, IFITM3, STAT1, NFkB) and the antigen presentation pathway (ERAP1, ERAP2, HLA-A and TAP). Overall, the results obtained suggest that HCO organoids may be infected by SARS-CoV-2 and their homeostasis may be significantly altered even following …