Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"IFI16"”.
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
… is unclear. Interferon-g inducible protein 16 (IFI16) is a putative DNA sensor that has also been proposed to induce interferon-b transcription via STING. This thesis demonstrates that both IFI16 and cGAS are required for full activation of immune responses to DNA and DNA virus infection in …
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Understanding and Exploiting Viral Protein US28 During Human Cytomegalovirus Latency
… MHC Class II and two PYHIN proteins, MNDA and IFI16, are downregulated during experimental latency in primary human CD14+ monocytes. By overexpressing IFI16, I show that IFI16 can activate the viral major immediate early promoter and immediate early gene expression during latency via NF-κB, a …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
… and innate immunity. Adding to this complexity, IFI16, another essential cellular factor, is recognized for its ability to enhance the binding of specific full-length viral segments to RIG-I and increase RIG-I signalling. In this study, I set out to understand what factors determine which IAV …
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Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… on restrictive cells and degrade both PML and IFI16, known targets of ICP0-mediated degradation. Conversely, the newly generated virus lacking both pUL55 and ICP0 was significantly inhibited in its ability to form plaques on restrictive cell monolayers and was unable to degrade PML or IFI16 in …
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The cell-intrinsic innate immune response to DNA damage in human cells
… pathway, the predominantly nuclear sensor IFI16 and the cytoplasmic adaptor protein STING, but was independent of the enzyme cGAS, which is essential for the immune response to cytosolic DNA. The transcriptional and signalling profiles of the Etoposide-induced response differ from those of …