Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"IEGs"”.
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
Immediate Early Genes (IEGs) are expressed upon re-entry of quiescent cells into the cell cycle following serum stimulation. These genes are involved in growth control and differentiation and hence their expression is tightly controlled. Many IEGs are regulated through Serum Response Elements …
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Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli
The promoters of immediate early genes (IEGs) are rapidly activated in response to an external stimulus. These genes, also known as primary response genes, have been identified in a range of cell types, under diverse extracellular signals and using varying experimental protocols. Genomic dissection …
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A Multi-Region Analysis of the Acquisition, Consolidation and Retention of Spatial Memory in the Morris Water Maze using Immediate Early Gene Imaging
… performance in this task. Immediate Early Genes (IEGs) have been implicated in learning and memory processes, and are used as markers of neural activity in a brain region in response to learning tasks. The use of adequate control conditions in these tasks has been identified as important, and we …
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Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy
… that adipocyte-related immediate early genes (IEGs) including CYR61, COX2, BTG2, and ZFP36 were overexpressed in active GO and to a lesser degree in chronic GO, but not in chronic lymphedema. CYR61-responsive genes were also upregulated in active GO. In Study V, associations were found between …
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Profiling hotspots of DNA breaks and learning-induced gene expression in the mouse brain
… induction of immediate early genes (IEGs). However, the locations of these DSBs in vivo and their relation to brain function was unclear. In Chapter 2, following contextual fear conditioning (CFC) of wild type mice, we profiled the locations of DSBs genome-wide through gH2AX ChIP-Seq, …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… which triggered immediate early genes (IEGs) activating the ATF4-ATF3 stress response pathway. Notably, changes in serotonin dynamics, including increased levels and serotonylation, were observed, suggesting that serotonylation may regulate cellular stress responses and contribute to …
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Dynamic Modulation of an Immediate -Early Gene in the Songbird Forebrain
… to salient events. Although the function of IEGs is not fully understood, one prominent model suggests that they are needed to consolidate memories of the inducing event---a ""feed-back"" model. However, a new ""feed-forward"" model suggests that IEG induction may serve to facilitate …
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Response Modulation by Single Units in the Auditory Neostriatum of Songbirds: Characterization of Responses and Their Relationships to Nuclear Gene Regulation in Adult and Juvenile Zebra Finches
… of the habituation signals the cell to induce IEGs. This model was tested by examining electrophysiological responses of NCM units in isolate d30, and normal d20 and d30 juvenile zebra finches. As in adults, NCM units in all juveniles responded robustly to song playback. Cells fired less …
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The molecular, hormonal and symptomatic responses to hypoglycaemia in mice
… low expression of immediate early genes (IEGs), which could evidence support for the successful minimisation of experimentally induced stress during the hyperinsulinaemic clamp technique. Numerous genes that were differentially expressed under hypoglycaemic or hyperglycaemic conditions …
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Molecular and epigenetic mechanisms of fear memory
… be triggered in some immediate early genes (IEGs) by neuronal activity, such as memory consolidation.Here, we used rat fear conditioning paradigms in combination with quantitative molecular assays, such as chromatin immunoprecipitation (ChIP), and gene editing techniques, like siRNAs and …
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Linking Molecular, Electrical And Anatomical Properties Of Human Epileptic Brain
… MAPK/CREB signaling, immediate early genes (IEGs), and synaptic plasticity genes in regions of high spiking. Bioinformatic analyses showed a number of clusters within the MAPK/CREB genes that include both activators and inhibitors of MAPK signaling. DUSP4, a member of a family of dual …
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Estudio toxicológico y electrofisiológico de ficotoxinas marinas: Mecanismo excitotóxicos y apoptóticos en cultivos primarios de neuronas
… de ARNm que codifican genes de expresión rápida (IEGs), alcanzando su pico máximo a las 5 h de exposición a la toxina. A estos tiempos, la PlTX incrementó la excitotoxicidad del DOM, mientras que exposiciones más largas (48 h) no incrementaron ni protegieron de la excitotoxidad del DOM, aunque …