Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"IEDDA"”.
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Developing unstrained alkenes and alkynes for bioorthogonal chemistry
… inverse electron-demand Diels–Alder reaction (IEDDA) reaction has its advantage of bearing the fastest kinetics. Although the IEDDA reaction drew considerable attention in chemical biology in the last decade, challenges lie in finding the suitable dienophiles. Strained dienophiles, for example, …
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Tetrazine-Triggered Bioorthogonal Decaging Reactions for Prodrug Activation
… drugs. The inverse electron-demand Diels-Alder (IEDDA) reaction between tetrazines and strained alkenes exhibits high reaction rates and selectivity and has been widely applied for the decaging of amine prodrugs. Although amines are common in small molecule drugs, decaging methods for other …
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The preparation of heterocycles by [2+2+2] cyclization and inverse electron demand Dels-Alder reactions of arynes with 1,2,4-triazines
… prepared. Inverse electron demand Diels-Alder (IEDDA) reactions of arynes and 1,2,4-triazines were also investigated for the generation of isoquinoline core structures. The results showed that only triazines with electron withdrawing groups participated in the IEDDA reactions with benzyne as a …
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An Inverse Electron-Demand Diels-Alder Strategy for Mapping RNA Methylation
… work, an inverse electron-demand Diels-Alder (IEDDA) reaction between allyl-modified nucleosides and a dipyridyl tetrazine was developed and characterised. This reaction uniquely generates a sterically bulky double-addition product for all nucleosides explored. To facilitate the creation of the …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
… use of the inverse electron demand Diels-Alder (IEDDA) reaction between a 1,2,4,5-tetrazine (Tz) and a <em>trans</em>-cyclooctene (TCO) for pretargeting. By separately injecting antibody and radioligand and allowing the two to “click” <em>in vivo</em>, overall dose to the patient can be reduced …
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The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… the inverse electron demand Diels-Alder (IEDDA) click reaction for diagnostic and therapeutic pretargeting; an overall introduction to antibodies in nuclear medicine; and a review based on the role of click chemistry and its advances in recent years.</p>