Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"IECs"”.
-
The intrinsic role of SOCS1 in intestinal epithelial cells
… by STAT1-dependent sensitization of Socs1- null IECs to apoptosis induced by immune cells-derived IFNγ in response to bacterial invasion. To define SOCS1 IEC-intrinsic role in the epithelium integrity and renewal, and for confirming that SOCS1 deficiency sensitizes IECs to IFNγ-driven cell death, …
-
“Nobody's ever asked me what it's like”: The role of family networks in the transitions of injured soldiers engaging with higher education.
… that, by supporting their injured ex-combatants (IECs) in complex and difficult transitions, the family network also had to address their own social identities, established attachments and kinship routines and adjust to new ways of thinking and feeling. However whilst the family network is seen as …
-
Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… there might be contributing factors intrinsic to IECs. We chose to establish a knockout cell line using the CRISPR/Cas9 system, given its affordability and efficiency compared to other in vitro models, and used it to study the effects of RAR⍺ ablation in IECs. Thus, our hypothesis was that RA …
-
Toxicological effects of metal oxide nanoparticles in combination with microbial components and inflammatory mediators on intestinal epithelial cells
… homeostasis. Intestinal epithelial cells (IECs) play a critical role in formation and maintenance of the intestinal epithelial barrier which functions as a protective barrier from microbial components, environmental pollutants, food particles, and other luminal content and xenobiotics. As …
-
Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… knockout in intestinal epithelial cells (IECs) develop spontaneous colitis at an early age. Moderate dietary protein has been demonstrated to exert beneficial effects for individuals with colitis, however, mechanisms of how dietary protein impacts inflammation development and immune …
-
The effect of the cast structure on the evolution of texture during processing of AISI 433 ferritic stainless steel
… while an initial equiaxed cast structure (IECS), promotes γ-fibre texture components. If both structures are present, they promote inhomogeneous texture, which leads to roping or ridging. However, in this work, the cast structures were mechanically separated and processed separately but …
-
Neutrophil Regulation of Colitis
… between microbiota, intestinal epithelial cells (IECs), and the intestinal immune system. As a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial barrier is breached and gut microbiota invade. Although …
-
The investigation of microbial-intestinal epithelial cell interactions in the gut and their effects on inhibitor of apoptotic proteins (IAPs)
… apoptosis in intestinal epithelial cells (IECs) when faced with cytokine challenge. Both in vitro and in vivo systems were exposed for a pre-determined time to Lp299v or strain Lpadh---a non-adherent derivative of Lp299v. HT-29 cells were then challenged with cytokine mixture (TNF-alpha, …
-
Modulators of Innate Gut Immunity to Enteric Viral Infections: Murine Norovirus (MNV) as a Model
… located between Intestinal Epithelial Cells (IECs) ready to respond to exogenous antigens in the intestinal lumen. The intestinal immune system is constantly influenced, not only by the commensal microbiota, but also by the nutritional status of the host and the availability of certain …
-
Immunomodulatory activity of Lacticaseibacillus rhamnosus R0011: analysis of secretome-mediated impacts on innate immune outcomes in intestinal epithelial cells and antigen presenting cells
… While host intestinal epithelial cells (IECs) and antigen-presenting cells (APCs) can interact directly with both commensal and pathogenic bacteria through innate immune pattern recognition receptors, recent evidence indicates indirect communication mediated by soluble mediators may be …
-
Lipid Signaling Under Microgravity Conditions
… Space stressors. Intesti-nal epithelial cells (IECs), which form the intestinal lining, respond to environmental insults – including pathogens and other abiotic stressors – by interacting with the immune system and triggering inflammatory responses. Inflammation represents a well-conserved and …
-
Identifying Protein Kinase Tbk1 As A Novel Inhibitor of Intestinal Tumorigenesis
… suppressor genes in intestinal epithelial cells (IECs). In addition, the initiation and progression of CRC involve environmental and immunological factors. In particular, chronic inflammatory conditions are known as an important risk factor for CRC. Intestinal inflammation can be caused by …
-
Activation and Maintenance of Intestinal Intraepithelial Lymphocytes (IELs)
… layer of intestinal epithelial cells (IECs) acts as a first line of defence. There is a T cell population located between the IECs that have been named intraepithelial lymphocytes (IELs). As the main lymphoid population within the intestinal barrier, IELs are thought to have an …
-
Mass spectrometry-based protein profiling strategies for biomarker discovery in liver and inflammatory bowel diseases
… fractions of intestinal epithelial cells (IECs) from healthy donors and Crohn’s disease patients were analysed. The combining of the low molecular weight serum proteins enrichment step and the LCMS approach allowed to evaluate a pattern of peptides derived from specific exoprotease activity …
-
Effects of dietary fiber components and gut microbiota products on the immune system: a focus on grape pomace as a novel source of fermentable substrates and bioactives
… and nitrogen reactive species levels in IEC-6 IECs and NR8383 APCs. In co-cultures, GPE pre-conditioned IEC-6 IECs downregulated LPS-induced TNF-α production by NR8383 APCs. Phosphoflow cytometry analyses revealed that GPE down-regulated key signaling molecules in the NF-κB and …
-
Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… also observed in intestinal epithelial cells (IECs) treated with AhR ligands. Thus, I3C and indirubin possess immunosuppressive and anti-inflammatory effects in BMDCs and IECs. Taken together, our data demonstrate that the AhR is a therapeutic target that warrants further investigation, as …
-
Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… also observed in intestinal epithelial cells (IECs) treated with AhR ligands. Thus, I3C and indirubin possess immunosuppressive and anti-inflammatory effects in BMDCs and IECs. Taken together, our data demonstrate that the AhR is a therapeutic target that warrants further investigation, as …
-
Improved lifetimes and synchronization behavior in multi-grid inertial electrostatic confinement fusion devices
… modeling to greatly improve the efficiency of IECs. These simulations show that the greatly increased confinement allows for the development of significant collective behavior in the recirculating ions. The plasma self-organizes from an initially uniform state into a synchronized, pulsing …
-
Synthesis and characterisation of hypercrosslinked polymer microparticles and their functionalised derivatives
… resins, satisfactory ion-exchange capacities (IECs) were obtained by treating the polymers with concentrated sulfuric acid as a sulfonating agent. In parallel with this work, SAX resins were prepared by treatment of the chloromethyl-containing polymers with dimethybutylamine as an aminating …
-
Modelling the interactions of Salmonellae with the human host using stem cell-derived intestinal organoids and macrophages
… pathogens. In vivo, intestinal epithelial cells (IECs) play a key role in regulating intestinal homeostasis, and can directly inhibit pathogens, although the mechanisms by which this occurs are not well understood. I have demonstrated that the cytokine IL-22 has a role in IEC defence against S. …
Page 1 of 2