Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"IEC-6"”.
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Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
… cell line Caco-2 and rat intestinal cell line IEC-6. The second aim of this study was to test the hypothesis that IL-1b, a major cytokine in IBD may inhibit glucocorticoid receptor action. Methods: The subcellular distribution of glucocorticoid receptor was studied by Western blot and …
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Régulation de la prolifération et de la différenciation des cellules épithéliales intestinales par les cascades MEK/ERK et AMPc/PKA
… humaine ou de rat. Dans les cellules humaines HIEC, l'expression d'une MEK CA entraîne un arrêt en phase G1 du cycle cellulaire et une sénescence prématurée caractérisée par (1) une augmentation de l'expression des protéines p53, p21 et p16[indice supérieur INK4A], (2) une morphologie …
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Effects of dietary fiber components and gut microbiota products on the immune system: a focus on grape pomace as a novel source of fermentable substrates and bioactives
… using human and rat intestinal epithelial cell (IEC) and APC lines. GP phenolic extract (GPE) demonstrated immunomodulatory and antioxidant activity, attenuating proinflammatory cascades and reducing oxidative stress in APC and IEC. GPE decreased proinflammatory chemokine production (CINC-1 and …
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Gata4 et Cdx2 sont des régulateurs transcriptionnels intestinaux du gène encodant la protéine sécrétoire de type lectine Pap1
… l'affinité de Gata4 pour l'ADN dans les cellules IEC-6/Cdx2. Les essais luciférase ont démontré que Gata4, en combinaison avec Cdx2, amène un effet synergique important sur l'activité du promoteur de Pap1 de l'ordre d'environ 8 fois. Différents mutants de la protéine Gata4 ont montré une abolition …
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Effects of Green Tea Extract (GTE) for Normal and Cancer Cell Death by Radiation
… 녹차추출물의 효과를 알아보고자 하였다. 본 실험에서는 마우스의 정상 소장 상피세포주인 IEC-6과 인간 대장암세포주인 HCT-116을 사용하였다. 방사선조사는 6MV 선형가속기를 이용하였고 실온에서 0, 2, 4, 6 Gy의 선량으로 조사하였다. 다양한 농도의 녹차추출물을 단독으로 처리하거나 녹차추출물 처리 후 방사선을 조사하고 MTT assay, clonogenic assay, ROS assay를 시행하였다. 방사선과 함께 0.025 및 0.05 mM의 녹차추출물을 사용하였을 때 방사선만을 조사받은 경우에 비해 정상 세포주인 …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… the effects of strain on the differentiation of IEC-6 intestinal epithelial cells in the absence or presence of cyclic strain. Strain increased Schlafen 3 mRNA and protein. In cells transfected with a control non-targeting siRNA, strain increased DPPIV specific activity. However, Schlafen</p> …
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Probiotic-derived factors as potential chemopreventive agents for intestinal mucositis and colon cancer
… with 30% rumen fluid. Rat epithelial IEC-6, human colonic adenocarcinoma Caco-2 and T-84 cells were treated with DMEM (control), growth media alone (without factors) or SNs, in the presence and absence of 5-FU. Cell viability (MTT), reactive oxygen species (ROS), cell apoptosis and …
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Caractérisation du rôle du récepteur P2X7 dans le transport du glucose par les cellules épithéliales intestinales et le contrôle de la glycémie et du métabolisme
… d’une diminution d’absorption dans les cellules IEC-6 et d’une diminution du transport transcellulaire à travers une monocouche de cellules Caco-2 différenciées. En fait, comme nous l’avons montrée, l’internalisation de GLUT2 est induite par une voie de signalisation impliquant les protéines …
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Role of the LPA2 Receptor in Protecting Against Apoptosis
… apoptosis and caspase 3, 8 and 9 activity in the IEC-6 cell line. The OTP- and LPA-elicited antiapoptotic effects were completely blocked by the MEK inhibitor PD98059 and the PI3K inhibitor LY294002. Pertussis toxin partially abolished OTP-induced ERK1/2 and apoptotic protection. In RH7777 cells …