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Showing 1 to 20 of 33 for “"IDR"”.

  1. Biomolecular condensation of intrinsically disordered regions in P. falciparum and H. sapiens transcription factors

    Karamanof, Leonidas MarthinusDepartment of Molecular and Cell Biology2022

    … driven by intrinsically disordered regions (IDRs) in proteins, has emerged as a previously underappreciated mechanism of cellular compartmentalisation and regulation. The study of eukaryotic transcription has been revolutionised by the understanding that biomolecular condensates formed by …

    cape-town Repository record

  2. Sequence-Based Properties that Identify Intrinsically Disordered Phase-Separating Protein Regions

    Ibrahim, AyyamTexas State University2022

    … that contain intrinsically disordered regions (IDRs), which are regions that do not adopt stable tertiary or secondary structures. While at least 40% of the human proteome is classified as IDPs, only a subset exhibit phase separation behavior. Previous work created a computer algorithm called …

    texas-state Repository record

  3. Characterizing Multivalent Interactions Between Folded Protein Domains and Intrinsically Disordered Regions or Peptide Substrates

    Zheng, Tongyin

    … by its middle intrinsically disordered region (IDR). The two folded domains of UBQLN2, the UBL and UBA domains, asymmetrically modulate LLPS by interacting with the IDR. We characterized the LLPS-inhibiting UBL-IDR interaction to be relatively strong and involves the STI1-I, linkers, and the …

    syracuse-diss Repository record

  4. A Study of Reconnection Poleward of the Cusp: Cluster and Polar

    Muzamil, Fathima M.

    … alter the structure of the ion diffusion region (IDR) in symmetric, collisionless reconnection. These features have been shown by numerical simulations under moderate density asymmetries (~10), and theoretical analyses. However, very few studies have addressed these issues with in-situ …

    unh-thes Repository record

  5. The Role of Phosphorylation In Pam2 Motif-Containing Proteins Mediated Messenger Rna Deadenylation

    HUANG, KAI-LIEH2017

    … inside the intrinsically disordered region (IDR) of its containing proteins. IDR is known to be a favored site for phosphorylation, and the PAM2 motif is surrounded by numerous potential phosphorylation sites. To test whether phosphorylation plays a role in controlling the interaction between …

    uthsc Repository record

  6. Assessment and optimisation of digital radiography systems for clinical use

    Doyle, PhilipUniversity of Glasgow2009

    … followed by indirect digital radiography (IDR) systems. To ensure and maintain diagnostic quality and effectiveness in the radiology department appropriate methods are required to evaluate and optimise the performance of DR systems. Current semi-quantitative test object based methods …

    glasgow Repository record

  7. Characterization of the Roles of Intrinsically Disordered Regions from RNA-Binding Proteins in Phase Separation

    Lin, Yuan2018

    … containing intrinsically disordered regions (IDRs). I demonstrate that IDRs, coupled with RNA binding domain and RNA, can phase separate in vitro, producing dynamic liquid droplets. Over time, these droplets mature into more stable states, as assessed by slowed fluorescence recovery after …

    utswmed Repository record

  8. Biophysical mechanisms of intrinsic protein disorder: lessons from a protein backbone model

    Drake, Justin AlexanderThe University of Texas Medical Branch at Galveston2019

    Intrinsically disordered regions (IDRs) in proteins populate a dynamic, heterogenous ensemble of structures. Proteins involved in the regulation of critical cellular functions rely on IDRs to carry out their functions. IDRs have been implicated in a number of diseases for which there are currently …

    utmb Repository record

  9. Stochastic prediction of collapse of building structures under seismic excitations

    Deniz, DeryaUniversity of Illinois at Urbana-Champaign2015

    … with IDA. The maximum inter-storey drift ratio (IDR) is often selected as the measure to represent the global behavior of structural system in the PBEE framework (Cornell et al., 2002). Likewise, assumed threshold values based on IDR or on slope of IDA curve between IDR and elastic spectral …

    uiuc Repository record

  10. WDR5 Network Analysis Using Ensemble Approaches

    Imran, Ali

    … the N-terminal intrinsically disordered region (IDR) of WDR5. Our work explores the self-association behavior catalyzed by this IDR and the potential ramifications of this self-association on WDR5's role inside the nucleus.</p>

    syracuse-diss Repository record

  11. Monitoring the Effects of the Oncogenic S250F Mutation on the Intrinsically Disordered C-terminal of FoxA1

    Hafrún Hákonardóttir 1998-2024

    … by two large intrinsically disordered regions (IDR). The C-terminal IDR is thought to play an important role for the pioneering activity of FoxA1. Mutations in FoxA1 have been strongly correlated with certain cancers, particularly breast cancer. A mutational hotspot found in FoxA1 in breast …

    u-iceland Repository record

  12. MOLECULAR REGULATION OF ATP-CITRATE LYASE

    Supplee, Julianna, Grace2025

    … located in an intrinsically disordered region (IDR). In this thesis, I analyze the cellular regulation of ACLY regarding alternative splicing and subcellular localization.Foremost, I identify epithelial splicing regulatory factor 1 (ESRP1) as one regulator of ACLY splicing. Although isoform …

    penn Repository record

  13. Multiscale coarse-grained models for biological phase separation: Development and applications

    Aguirre Gonzalez, AneUniversity of Cambridge2023

    … of a set of intranuclear proteins (*i.e.* MED1 IDR, BRD4 IDR, Nanog CTD, and DDX4 and DDX3 variants) qualitatively. Overall, our multiscale modelling approach shows great potential at bridging the gap between atom-level observables, to single-molecule behaviour, to macroscopic phase transitions, …

    cambridge Repository record

  14. Functional dissection of the S. cerevisiae helicase activating factor Cdc45

    Chan, Sze Ham (Sze Ham Bena)Massachusetts Institute of Technology2013

    … a predicted intrinsically disordered region (IDR). Oddly, a complete deletion of the IDR is dispensable for Cdc45 function in vivo. Mutants that failed to fully complement a CDC45 deletion in vivo were purified and tested for their ability to complement Cdc45 function biochemically. Purified …

    mit Repository record

  15. The Nucleolar Protein Nucleophosmin Undergoes Liquid-Liquid Phase Separation with Arginine-Rich Nucleolar Proteins through Weak, Multivalent Electrostatic Interactions

    Cika, Jaclyn Alicia2017

    … two within an intrinsically disordered region (IDR), confer additional multivalency and mediate interactions with proteins that contain multiple arginine-rich motifs (R-proteins). Using a variety of techniques, we have identified several nucleolar R-proteins which bind to and phase separate with …

    tenn-hsc Repository record

  16. Prevalencia de desnutrición relacionada con la enfermedad en pacientes hospitalizados y coste asociado. Adecuación de la ingesta nutricional.

    Barcina Pérez, Pablo2021

    … podrían ser superiores a los propuestos como IDR. En este sentido, se debe considerar que continúan existiendo carencias en lo que respecta a normativas oficiales de estandarización tanto las denominaciones de las dietas como sus características nutricionales en hospitales.

    murcia-diss Repository record

  17. Electrical Demand Analysis Software Tool Suite and Automatic Report Generation for Energy Audits

    Morelli, Franco Javier2015

    … clients augmented with Interval Data Recorder (IDR) meters, the Industrial Assessment Center at Texas A&M has developed a suite of electrical analysis tools designed to increase analysis fidelity, identify pre-visit Energy Conservation Measures (ECM), establish unknown variables helpful in …

    tdl Repository record

  18. Internal dispute resolution: the legal environment of complex public organizations

    Haraway, William M.Virginia Tech1999

    … the legalization of internal dispute resolution (IDR) in the Commonwealth tends to result in the circumvention of immediate supervisors in the formal grievance process, thereby obviating their positional authority to resolve employee grievances in a nonadversarial way. In sum, data supports the …

    vt Repository record

  19. Functional organic thin films under extreme confinement

    Kafle, PraptiUniversity of Illinois at Urbana-Champaign2022

    … in solubility and intrinsic dissolution rate (IDR) upon decrease in film thickness. The experimental results closely matched this model and we demonstrated a drastic increase in IDR upon decreasing the thickness and increasing disorder in the films. Next, I explored into two-dimensionalization …

    uiuc Repository record

  20. Deciphering The Role of Hsp110 Chaperones In Diseases of Protein Misfolding

    Yakubu, Unekwu M., <p><strong>0000-0003-2230-0066</strong></p>2021

    … predicted short intrinsically disordered region (IDR) in both fly and human Hsp110s. I demonstrate for the first time the carboxy-terminal IDRs in fly and human Hsp110s effectively prevent aggregation of numerous substrates, including amyloidogenic peptides Aβ<sub>1-42</sub> and α-synuclein, …

    uthsc Repository record

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