Global ETD Search
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Showing 1 to 19 of 19 for “"IDO1"”.
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Structure guided discovery of inhibitors of indoleamine 2,3-dioxygenase (IDO1)
The enzyme indoleamine 2,3‐dioxygenase‐1 (IDO1) plays a critical role in the regulation of the immune system. IDO1 expression is commonly upregulated in cancer, resulting in a suppressed immune system in patients. Clinical observations that patients with high IDO1‐expressing tumours have a poor …
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Mechanism of Chimeric Vaccine Mediated Immune Suppression of Human Dendritic Cells
… catabolic enzyme indoleamine 2, 3-dioxygenase (IDO1) shown to be directly linked to CTB-INS-induced DC activation and maturation. Treatment of vaccinated DCs with the pharmacological NF-κB inhibitors ACHP or DHMEQ inhibited IDO1 biosynthesis, suggesting a role for NF-κB signaling in CTB-INS …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has also been implicated in neurodegenerative disease and depression. IDO1 activity increases kynurenine concentrations in circulation and brain tissue following LPS administration. Further, IDO1 has been shown to be necessary for the …
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The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… tolerance in human DCs indicate that increased IDO1 biosynthesis may play an important role in CTB-INS vaccine inhibition of DC activation. Previous studies suggest transforming growth factor beta (TGF-β) may play a role in the stimulation of IDO1 biosynthesis for induction of immunological …
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Stress and inflammation regulate the kynurenine pathway dioxygenases in a glia‐ and tissue‐specific manner
… and indoleamine 2,3-dioxygenases (DOs: Tdo2, Ido1 and Ido2). The DOs are rate-limiting for tryptophan metabolism by the Kynurenine Pathway. While accumulating evidence supports an interconnection between symptoms of depression and increased Kynurenine Pathway activity, the cellular specificity …
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Σύνθεση, χαρακτηρισμός και in vitro αξιολόγηση διαρυλοθειολών ως πιθανών αναστολέων της μεταβολικής οδού της κυνουρενίνης
… στον καρκίνο. Η ινδολεάμινο-2,3-διοξυγενάση 1 (IDO1), η ινδολεάμινο-2,3-διοξυγενάση 2 (IDO2) και η 2,3-διοξυγενάση της θρυπτοφάνης (TDO) είναι τα κύρια ένζυμα που ρυθμίζουν το πρώτο και καθοριστικό βήμα του μεταβολισμού της ανοσοκατασταλτικής οδού της κυνουρενίνης, στο οποίο επιτυγχάνεται η …
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Effects of β-funaltrexamine on lipopolysaccharide-induced inflammation and behavior
… were measured in mouse plasma via ELISA. IDO1 and NLRP3 transcription were quantified via RT-qPCR from whole cell lysates and the afore-mentioned tissue homogenates. Additionally, p38 MAPK and STAT1 were quantified via Western blots in whole cell lysates. Acute β-FNA selectively reduced …
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A detailed investigation into potential genes and their variants regulatory sequences causing endometriosis and how the environment may impact upon these
… to environmental insults. These were CNR1, IL-6, IDO1, KISSR1, and TACR3. EDCs are commonly found as part of cosmetics and other personal care items routinely used by women. Conclusion The findings of this project suggest that a genetic susceptibility to developing endometriosis could be …
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The Influence of Preovulatory Estradiol on Uterine Transcriptomics and Proteomics Around Maternal Recognition of Pregnancy in Beef Cattle
… COL1A2) and 179 were upregulated (PRSS8, FABP3, IDO1, MUC13, CXCL10) in the highE2/conceptus group. There were 48 differentially expressed proteins (DEPs) among the highE2/conceptus and lowE2/conceptus groups (19 upregulated, 29 downregulated in the highE2/conceptus group), 6 of these were …
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In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
… by cancer cells such as PD-L1, CD47 and IDO1. Although cancer cells could use many more genes to evade detection by the immune system, methods to systematically identify such genes are lacking. To discover new immunotherapy targets, we developed a pooled, loss-of-function in vivo genetic …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… Despite the induction of suppressive mediators IDO1, IDO2 and TGFâ3, TCDD-BMDCs failed to suppress T cell activation <i>in vivo</i> or induce the generation of adaptive T-regs <i>in vitro</i>. Collectively, our data suggest that AhR activation disrupts DC homeostasis, modulates DC …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
… Despite the induction of suppressive mediators IDO1, IDO2 and TGFâ3, TCDD-BMDCs failed to suppress T cell activation <i>in vivo</i> or induce the generation of adaptive T-regs <i>in vitro</i>. Collectively, our data suggest that AhR activation disrupts DC homeostasis, modulates DC …
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Understanding factors that affect gene co-regulation patterns
… enzyme Indoleamine 2,3-dioxygenase (IDO1) activated during the inflammatory process. The goal of this study was to understand pathways associated with depression-like symptoms after recovery from immune challenge and deficiency of a gene associated with depression-like symptoms. The …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… LAMP3+ DCs (mregDCs) enriched for IDO1 expression and immune checkpoint ligands. Natural Killer (NK) and Innate Lymphoid Cells (ILCs) showed strikingly distinct patterns between blood and tumor tissues. Circulating NK cells followed a canonical CD56bright-to-CD56dim trajectory, …
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Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems
… the mRNA levels of only CCL5, CXCL10, CXCL11, IDO1, IFNB1, IRF7, and TLR3 we increased during infection of each viruses. The measurement of CCL5, CXCL10, CXCL11, IDO, and IFN-β secreted protein levels in the same HLMVEC donor during infection confirmed gene expression findings. The study of …
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Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
… upregulation of MRC1 and downregulation of IDO1, suggesting an anti-inflammatory phenotype consistent with previous findings. Gene set enrichment analysis identified pathways downregulated in several T cell subsets related to cytokine signalling including TNF receptor 2 signalling and …
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Effective Strategies for Preventing and Mitigating Emerging Viruses
… three IFNγ-regulated antiviral genes (Gbp1/2 and Ido1) that were highly upregulated in 3T3 mouse fibroblasts post-infection with the IFN-γ-expressing candidate but not the parental backbone. To further investigate the role of these genes in restricting viral replication and enhance the clinical …
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Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
The non-hematopoietic, stationary stromal cells located inside and surrounding skin-draining lymph nodes play a key role in regulating immune responses. We studied distinct populations of lymph node stromal cells from both human subjects and animal models in order to describe their phenotype and …
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The roles of indoeamine-2,3-dioxygenase 1 and 2 during TMEV- and kainate-induced ictogenesis
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01