Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"IDH1"”.
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Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)
… novel covalent Isocitrate Dehydrogenase 1 (IDH1) inhibitor in Acute Myeloid Leukemia, it</strong> <strong>is more effective than Ivosidenib (AG120) and has a potent anti-leukemic effect against IDH1 mutant acute myeloid leukemia in combination with Venetoclax (ABT-199).</strong></p> <p>Acute …
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RAPID DETECTION OF THE IDH1 R132H MUTATION IN GLIOMAS USING RECOMBINASE POLYMERASE AMPLIFICATION
… developed an assay to improve diagnosis of the IDH1-R132H mutation. Diagnosis guided resections has potential to extend life expectancy up to 10 years. Our assay identifies the status of the IDH1-R132H mutation which has a characteristic of slower growth. Surgery requires a delicate balance …
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Atrx Inactivation and Idh1-R132H Drive Preferential Sensitivity to Proton Vs. X-Ray Radiotherapy In Glioma Stem Cells
… individually linked IDH mutations, specifically IDH1<sup>R132H</sup>, and ATRX inactivating mutations to improved patient outcomes and suppressed DNA damage repair compared to their respective wild-types, the mechanisms by which these two genetic alterations interact in GSCs treated with PRT …
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A Rapid Colorimetric Peptide Nucleic Acid Loop-Mediated Isothermal Amplification Assay for the Detection of the IDH1 Mutation in Glioblastoma
<p>The <em>IDH1</em> mutation is an important diagnostic and prognostic biomarker used to characterize glioblastoma (GBM). Patients harboring the <em>IDH1</em> mutation have improved overall survival following maximal resection. Knowledge of the <em>IDH1</em> mutation status allows the surgeon to …
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
<p>Isocitrate dehydrogenase 1 (<em>IDH1</em>) is a biomarker in gliomas which provides valuable information on patient prognosis and treatment. Targeted therapies including maximal surgical resection and pharmaceutical mutant IDH inhibitors offer life extending benefits; however, currently …
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… This was done using various approaches such as IDH1 and IDH2 mutation analysis, MGMT methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially expressed miRNAs using miRNA microarray analysis. IDH1 mutation was present at a …
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The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency
… reversible isoforms of isocitrate dehydrogenase (IDH1 and IDH2) and undergo rapid cell death when glucose becomes scarce. Reasoning that these cell lines could be used to address basic questions about the contextual roles of IDH1 and IDH2 in regulation of the reductive carboxylation pathway, they …
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ANALYSIS OF TUMOR SPECIFIC PROTEIN EXPRESSION IN GLIOBLASTOMA MULTIFORME (GBMs) TUMORS THROUGH IMMUNOHISTOCHEMISTRY
… GBM tumors with isocitrate dehydrogenase-1 (IDH1) mutation being expressed, lead to higher survival rates in patients that also have full resection of the tumor and chemotherapy. Without this mutation, it is thought that tumors have a higher expression of the protein Basigin and …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… their mutational status for the hotspot mutation IDH1 R132H in glioma. First, in Chapter 2 we deeply characterised the statistical properties of data generated from TCR repertoire sequencing, in order to understand the source and amount of expected technical noise in experimental data. …
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<i>PTHR1/SOX9</i> and <i>IDH1/IDH2</i> Relative Expression in Primary Chondrocyte and Chondrosarcoma Cells Under the Synergistic Influence of Inducible Hypoxia and Extracellular Acidosis
… chondrosarcoma grade II cell lines, JJ012-<em>IDH1</em> mutant and SW1353-<em> IDH2</em> mutant, were grown in four experimental conditions: hypoxia (5% O2), acidosis (pH=5.5), hypoxia and acidosis, and normoxia/(pH=7). Four genes of interest were analyzed via RT-qPCR relative to the …
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Combination of CT-based Radiomics Features and Clinical Data for Predicting Tumor Genetic Profile in patients with Intrahepatic Cholangiocarcinoma
… common genetic alterations were FGFR2 (20/90), IDH1 (10/58), and KRAS (9/58). Combined clinical-radiomic models showed the best performance in predicting FGFR2 (AUC = 0.892) and IDH1 status (AUC = 0.819), outperforming clinical or radiomic models alone. The radiomic model for KRAS mutations …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… that glioma-derived factors, released by U87 IDH1-WT and IDH-MUT, are able to polarize macrophages toward a pro-tumoral M2-like phenotype with the increase of the CD206 expression. Moreover, the effect of TCM collected from U87 IDH1-MUT is different compared with TCM from U87 IDH1-WT on …
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Design and development of an electrochemical and infrared spectroscopic medical device for serum-based cancer diagnostics
… modalities. Additionally, the ability to detect IDH1molecular status from serum samples would have significant clinical value to patientsand clinicians alike, ultimately allowing earlier diagnosis and improved planning ofsurgery and treatment therapeutics. To this extent, the medical device …
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Implicaciones pronósticas de la relación subventricular en el gliobastoma multiforme: caracterización clínica, radiológica y patológica
… marcadores Olig2, PGFA, EGFR, p53, MGMT, NFP, IDH1 e YKL-40 sobre una muestra de 204 pacientes, estratificados por grupos ( I, II, III, IV y V) en función de la relación subventricular, los cuales a su vez se subdividieron en profundos (I, II, V) y superficiales (III y IV). Los GBMs del grupo I …
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
… of 60. Over 80% of secondary gliomas contain an IDH1R132H mutation, resulting in neomorphic mutations, which catalyze isocitrate to the oncometabolite D-2-hydroxyglutarate (2-HG) instead of alpha-ketoglutarate (α-KG). As 2-HG accumulates, it induces a hypermethylator phenotype that prevents the …
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Understanding transcriptional regulation through computational analysis of single-cell transcriptomics
… As for the leukaemia system, FLT3-ITD and IDH1-R132H mutations were shown to interact with each other and potentially predispose some cells for developing acute myeloid leukaemia.
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Perfiles de expresión de microRNAs y de alteraciones genéticas en tumores de origen glial
… de EGFR, presencia de EGFRvIII, mutaciones en IDH1 estado de metilación del promotor de MGMT y número de copias de CDKN2A, TP53, PTEN, 1p /19q y NF1. En glioblastomas resultaron factores pronósticos de forma independiente la cirugía, el tratamiento postquirúrgico, la amplificación de EGFR y la …
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Orthogonal Comparison of Nuclear and Mitochondrial Clonal Architectures in Hematologic Malignancies
… defined by nuclear mutations such as DNMT3A, IDH1, and ASXL1 frequently exhibited co-segregating mitochondrial variants, suggesting shared clonal ancestry. Comparison of mtDNAand nDNA-derived phylogenies showed partial concordance, particularly in recent clonal expansions, while older lineages …
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