Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"IDH"”.
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Gestão pública e IDH-M de Fortaleza/CE: saúde, educação, renda e inclusão de crianças com alergia alimentar nas escolas.
… Índice de Desenvolvimento Humano do Município (IDH-M) de Fortaleza, Ceará, no período de 2000 a 2010, para que sejam feitas observações a cerca da Gestão Pública Municipal, através de uma análise documental de dados oficiais disponibilizados no Relatório de Desenvolvimento Humano, divulgado pelo …
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Impacto del canon minero en el índice de desarrollo humano (IDH) en las principales regiones mineras del Perú. periodo 2017-2024
… público— sobre el Índice de Desarrollo Humano (IDH). El análisis se desarrolla en las principales regiones mineras del Perú —Áncash, Apurímac, Arequipa, Ayacucho, Cajamarca, Cusco, Huancavelica, Huánuco, Ica, Junín, La Libertad, Lima, Moquegua, Pasco, Puno y Tacna— durante el periodo 2017–2024. …
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NEW ADVANCES IN QUANTITATIVE RADIOLOGY: RADIOMICS IN NEURORADIOLOGY APPLIED TO PRIMARY BRAIN TUMORS USING A MACHINE LEARNING APPROACH
… labelling (ASL) radiomics analysis to predict IDH mutation and MGMT methylation status in gliomas Fabio M. Doniselli1,2, Riccardo Pascuzzo1, Eleonora Bruno3, Domenico Aquino1, Mattia Verri, Alberto Redolfi, Valeria Cuccarini1, Marco Moscatelli1,2, Maria Grazia Bruzzone1, Luca Maria …
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Exploring the immunologic consequences of ATRX deficiency in glioma
… tumor types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic regulation at a cell level; however, less is known about the impact of ATRX mutation on immune signaling. …
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DPN-linked isocitrate dehydrogenase from fly thoracic muscle mitochondria
… the basis of chromatographic pattern. DPN-linked IDH has been isolated from face fly thoracic muscle mitochondria and purified 50-fold from the initial mitochondria acetone powder extract in good yield (22%). The enzyme may be stored without loss of activity as a suspension in 0.3 sat. (NH₄)₂SO₄ …
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… Mutations in enzymes isocitrate dehydrogenases (IDH) occur in GBM subsets, characterized by more favorable prognosis. Also, other molecular alterations and metabolic features, such as accumulation of the oncometabolite 2-hydroxyglutarate, are associated with IDH-mutations. Despite many …
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A impunidade de agentes estatais nos casos julgados pela Corte Interamericana de Direitos Humanos
… Corte Interamericana de Direitos Humanos (Corte IDH) impôs aos Estados para investigar, julgar e condenar os agentes estatais responsáveis por violações de direitos humanos. Para tanto, realizou-se uma análise em dois planos: (a) no internacional (sistêmico), discutiu-se sobre as estruturas …
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Studies of a restricted signature of circulating miRNAs as non-invasive biomarker in glioma: from the molecular function to the clinical application
… mutations of the isocitrate dehydrogenase (IDH) genes are noteworthy. Altered miRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a very stable form, making them interesting candidate as biomarkers. Several circulating miRNAs have been …
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A novel GC-MS/MS assay for the measurement of 2-hg enantiomers and the utility of 2-hg enantiomer levels as a biomarker for IDH mutant gliomas
The isocitrate dehydrogenase (IDH) gene has recently been identified to be mutated in gliomas, a malignant brain tumor. Mutant IDH (IDHmut) produces the oncometabolite, (R)-2-hydroxyglutarate (R-2-hg), resulting in a significant increase of intracellular concentrations above physiological levels. …
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
<p>Isocitrate dehydrogenase 1 (<em>IDH1</em>) is a biomarker in gliomas which provides valuable information on patient prognosis and treatment. Targeted therapies including maximal surgical resection and pharmaceutical mutant IDH inhibitors offer life extending benefits; however, currently …
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The bees of Niagara: a test of the intermediate disturbance hypothesis /
… The intermediate disturbance hypothesis (IDH) was tested by selecting field sites subject to low, intermediate, and high disturbance. Intermediate disturbance had the highest species richness (SR=1 15) and most bees (N=556I), followed by low disturbance (SR= 100, N=2975), then high …
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Population structure, biochemical adaptation and systematics in temperate marine fishes of the genera Arripis and Chrysophrys (Pisces: Perciformes)
… carried out on snapper isocitrate dehydrogenase (IDH) and salmon malic enzyme (ME) allozymes to determine whether or not functional differences existed in response to temperature fluctuation. It was found that differences did exist between IDH allozymes, but that the functional variation was …
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Population structure, biochemical adaptation and systematics in temperate marine fishes of the genera Arripis and Chrysophrys (Pisces: Perciformes)
… carried out on snapper isocitrate dehydrogenase (IDH) and salmon malic enzyme (ME) allozymes to determine whether or not functional differences existed in response to temperature fluctuation. It was found that differences did exist between IDH allozymes, but that the functional variation was …
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Three enzymes - One substrate Regulation of carbon flux through a "non-canonical" metabolic branchpoint
… isocitrate dehydrogenases (ICD and IDH). For this PhD project, I focused on these three enzymes (ICD, IDH and ICL). I cloned, overexpressed and purified them at high yield to perform a thorough investigation of their kinetics, regulation and more interestingly crystal structures. I …
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Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
… mutation of isocitrate dehydrogenase (<em>IDH</em>) is associated with genome-wide hypermethylation of CpG islands in gliomas. But other subtype-associated alterations, including telomerase reverse transcriptase (<em>TERT</em>)<em> </em>promoter mutation, alpha thalassemia/mental …
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Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
… mutation in gliomas, making the diagnosis of IDH mutant gliomas possible without biopsy. 2HG also has a significant predictive value with respect to the stage and survival in gliomas because IDH mutation carries a favorable prognosis. Gliomas are highly heterogeneous and infiltrative in …
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Acidentes de trânsito fatais e sua associação com indicadores sociais e adolescência
… índice municipal de desenvolvimento humano (IDH-M), índice de condições de vida (ICV), proporção de condutores adolescentes envolvidos em acidentes de trânsito com vítimas (PCJ-ATV) e proporção de residentes jovens (PRJ) nas diferentes capitais. Em um segundo momento, realizou-se um estudo de …
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Implementación de las sentencias internacionales sobre derechos humanos: de la ejecución al impacto
… Corte Interamericana de Derechos Humanos (Corte IDH) y Corte Africana de Derechos Humanos y de los Pueblos (CADHP)- que surgieron dentro de sistemas de protección a derechos humanos continentales, creados en diferentes momentos históricos para proteger los tratados signados en esta materia por …
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