Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"ID1"”.
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
… Inhibitor of Differentiation proteins 1 and 3 (ID1/3) are transcriptional regulators that control many cell fate and developmental processes and are often deregulated in cancer. Our group and others have previously demonstrated that ID1/3 are required and sufficient for the metastasis of breast …
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Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins
RNA polymerase III (pol III) is responsible for transcribing a set of genes that are involved in protein synthesis, including transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Pol III transcription levels are increased in many cancers, as increased protein synthesis is required for tumour growth. …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… IEGs in SRF-depleted fibroblasts. One of these, Id1, was examined more closely. We mapped a serum responsive element in the Id1 promoter and find that it is identical to a BMP Responsive Element (BRE). The Id1 BRE is necessary and sufficient for the serum regulation of Id1. Inhibition of the BMP …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… of the inhibitor of differentiation 1 (Id1) gene. Ectopic Smad7 expression reduced Id1 expression. Conversely, Id1 overexpression in HSC enhanced cell activation and circumvented Smad7-dependent inhibition of transdifferentiation. Moreover, knock-down of Id1 in HSC interfered with the …
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Roles of proteasome, arachidonic acid, and oxytocin in bovine myoblast proliferation and differentiation
… and fusion. Inhibitor of DNA-binding 1 (ID1) is known to inhibit myoblast differentiation and to be degraded by the proteasome in some cells. Both ID1 protein and mRNA expression were found to decrease during myoblast differentiation and fusion, and the decrease in ID1 protein but not ID1 …
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TWIST1: a subtle modulator of neural differentiation and neural tube formation
… of the BMP signalling both in vivo and in vitro. ID1 is a direct target of BMP signalling with major influence on in vitro neural differentiation. A cDNA library screen, looking for transcription factors negatively regulated by ID1, reported TWIST1, along with only two other proteins. Twist1 …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… regulate its oncogenic activity and (3) whether ID1 (inhibitor of differentiation 1) is transcriptionally activated by TBX3 to mediate its pro-migratory function in breast cancer. To elucidate the molecular mechanism(s) that upregulate TBX3 in breast cancer, this study hypothesised that it may …
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Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells
… Also, these catechin compounds increased id1 target gene expression in the presence and absence of BMP type-II-receptors. The data of this study demonstrated that catechin compounds might exert an inhibitory effect on TGFβ signalling and promote BMP signalling. Finally, in this research, …
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The contribution of reorganised motor pathways to recovery of arm and hand function after stroke
… on response amplitudes in deltoid, biceps and ID1 were compared. Second, the effect of increasing stimulus intensity on recruitment of low threshold motor units was assessed for deltoid and ID1. In addition the change in response amplitude with increasing voluntary activity in the affected and …
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Differentielle Genexpression bei der Membranösen Glomerulonephritis und die Rolle des 'bone morphogenetic protein 2' für die Funktion des Podozyten
… 'inhibitors of DNA binding'-Proteine 1 bis 4 (Id1-4), die durch Hemmung der Protein-Kinase C nicht zu beeinflussen ist. <br>Diese Ergebnisse weisen darauf hin, daß BMP-2 eine Bedeutung in der Morphogenese der mGN-geschädigten Niere zukommt und daß es möglicherweise über autokrine Stimulation …
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Interruptores moleculares basados en azobencenos y ciclodextrinas : aplicación en sistemas miméticos de factores de transcripción
… en fase sólida dos fragmentos de la proteína Id1, que es inhibidor transcripcional del FT MyOD. Luego del corte de la resina y de una laboriosa purificación hemos obtenido dos fragmentos del Id1, H1 (extremo N-terminal) y H2 (extremo C-terminal) puros. Hemos intentado, acoplar a estos …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
… inhibitor of DNA-binding/differentiation genes, ID1 and ID2. In vivo, BMP9 administration reduced neonatal retinal and pulmonary vascular density in controls, but enhanced both measures in Bmpr2EC-/- mice. Conclusion: Loss of BMPR2 results in a shift of the endothelial BMP9 response towards …
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Role of MDM2 In Cell Growth Regulation
… 1-220 amino acids including inhibitory domain ID1 does not effectively prevent BrdU incorporation in an immortal cell line that is non-responsive to growth arrest by the cyclin A inhibitory domain. This suggests that induction of MDM2 leads to G1 arrest by at least two independent mechanisms, …
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Quantification of gene expression in single cells
… Pou5f1 correlates with the transcription factors Id1 and Id3. We conclude that quantitative gene expression measurements on single cells allow: 1) studies of cell population heterogeneity and noise in gene expression; 2) exploration of genes that are co-regulated; and 3) correlation of gene …
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BMP9 Signalling in Ovarian Cancer
… role in the aetiology of said growth phenotype. ID1 gene expression was found to significantly contribute to the BMP9 proproliferative phenotype. Moreover several other BMP genes identified significantly alter basal cell proliferation. It was subsequently determined that BMP9 implemented a cell …
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Novel genomic technologies and molecular diagnostics in Colorectal Cancer
… known cancer pathway genes as STK4 and ID1, and homozygous deletions (HoD) containing potential new candidate tumor, suppressors such as BTG4 and D4S234E were located on chromosomes 11 and 4. Recurrent somatic focal events (gains and losses) were identified in regions encompassing …
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A comprehensive survey of somatic mutation landscapes in normal human cells
… signatures encompassing SBS1 and SBS5 or ID1 and ID2 are present to varying degrees across all tissue structures. While some mutational signatures, such as SBS4, SBS7, or SBS88, are associated with unique aetiologies, many signatures have unknown causes. Furthermore, two previously …
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Isolation, characterisation and in vitro potential of Oogonial stem cells
… significant upregulation of expression of ID1 and bovine cells exhibiting a significant increase in MSX1, MSX2 and the meiotic marker SYCP3 in response to BMP4 and/or RA treatment. Cells could be successfully transfected to overexpress DAZL; however, no significant downstream gene …
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THE SHORT- AND LONG- TERM EFFECT OF ZINC AND COPPER CONTAMINATION ON SOIL MICROBIAL FUNCTIONS
… data were collected at the HXMA beamline (06-ID1). Overall these studies provide new insights into the long-term consequences of Zn and Cu in soils. This study showed that soils dosed with zinc in the form of ZnSO4 did not undergo the changes in metal speciation to become less available, which …