Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"ICP0"”.
-
ANALYSIS OF HERPES SIMPLEX VIRUS ICP0 FUNCTION AND THE ANTIBODY RESPONSE TO A LIVE HSV-2 ICP0- MUTANT VACCINE
… early viral protein, infected cell protein 0 (ICP0). ICP0 is a potent transactivator of HSV mRNA synthesis. However, in addition to the nuclear transactivating function of ICP0, our lab demonstrated that at later times during infection, ICP0 translocates from the nucleus to the cytoplasm where …
-
Gene regulation and function of ICP0 in herpes simplex virus infected cells
… and latency. Infected cell protein 0 (ICP0) is generally believed to play a key role in determining the outcome of HSV infections. Synthesis of ICP0 promotes the productive replication of HSV, whereas absence of ICP0 renders HSV prone to establish latent infections. In the first part of …
-
PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
… Herpes simplex virus immediate-early protein ICP0 is a multifunctional regulator of herpes simplex virus infection. Late in infection ICP0 interacts dynamically with cellular proteasomes. ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for its IE functions. …
-
Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… immune modulator with similar functions to ICP0. ICP0 exhibits E3 ubiquitin ligase activity and is known to stimulate proteasomal degradation of several host proteins in HSV-1 infected cells. Multiple studies to date have used the *dl*1403 mutant strain of HSV-1, engineered to lack ICP0, …
-
Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
… E3-ubiquitin ligase, Infected Cell protein 0 (ICP0), is often correlated with latency establishment but is detected in opposition to the state of latency. During lytic infection, ICP0 has many biological roles but primarily catalyzes the addition of ubiquitin to target substrate, marking …
-
A Host Regulatory Circuit of HSV Gene Expression
… latent cycles, where the immediate-early protein ICP0 plays a critical role in driving lytic replication and reactivation from latency. During this complex process, HSV-1 triggers STING, a host factor that inhibits viral infection. It is well established that STING mediates antiviral immunity by …
-
Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… profiles of viral immediate-early (IE) genes ICP0, ICP4, ICP27 and trans-activator VP16 following treatment with stress hormones and NTF deprivation in HSV-1 and HSV-2 infected neurons. We also show that different molecular mechanisms are involved in HSV latency and reactivation, which are …
-
An exploration of the interplay between HSV-1 and the non-homologous end joining proteins PAXX and DNA-PKcs
… previously been reported that the HSV-1 protein ICP0 targets DNA-PKcs for degradation, although the reason for this is unknown. We confirmed these data, although found it to be cell-type specific and explored this interaction further using PRKDC-/- RPE-1 cells created using CRISPR/Cas9. HSV-1 …