Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ICOSL"”.
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
… time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis (EAMG), a model of human MG. Following acetylcholine receptor (AChR) immunization, ICOS gene-deficient mice were resistant to the development of EAMG due to faulty germinal center …
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FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… between the FOXP3 rs2294020, ICOS rs6726035 and ICOSL rs378299 SNPs and the susceptibility to SSc or to progression from preclinical SSc to definite SSc in a North Italian Caucasian population. Furthermore, we have extended our association analysis of the FOXP3 rs2294020 SNP also in 14 GWAS …
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Étude de l’expression et du rôle du ligand du co-stimulateur inductible des cellules T (ICOSL) dans les ostéoclastes humains
… molecules such as CD80/86 or PDL-1, we studied ICOSL expression in human osteoclasts, and its impact on multinucleation and bone resorption, two phenotypic features of these cells. We were able to demonstrate ICOSL expression in our model of fetal monocyte-derived osteoclasts in long-term …
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Novel immunotherapy for paediatric cancers
… from individual patients. High CD86, CD70 and ICOSL was associated with bad CART cell persistence while OX40L and IL10 expression - with good CART cell persistence and delayed CART cell exhaustion. Inclusion of 4-1BB in CAR design reduced CART activation but delayed their exhaustion. It also …