Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"ICOS"”.
-
Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
The inducible costimulator (ICOS) is a member of the CD28 family of costimulatory molecules and plays a central role in T-cell-mediated immunity. In this study, we investigated the molecular regulation of ICOS expression during early activation of CD4+ T cells by T cell receptor and CD28 …
-
Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
The inducible costimulatory molecule (ICOS) is a relatively new member of the CD28 family of costimulatory molecules. For the first time, we have characterized the role of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis (EAMG), a model of human MG. Following acetylcholine …
-
FOXP3, ICOS and ICOSL polymorphisms in an Italian population affected by systemic sclerosis
… and/or co-inhibitory signals, including ICOS signalling, can cause a breakdown of self-tolerance, thus leading to autoimmunity. Furthermore, ICOS has been linked to the function of Tregs. The aim of the present study was to investigate the association between the FOXP3 rs2294020, ICOS …
-
On the role of treml6 in B-1a B cell development And ICOS co-stimulation in adaptive immune responses against M. tuberculosis
… der IFN-γ sekretierenden CD4+ Th1 Zellen ICOS exprimierten. Dementsprechend lag die Vermutung nahe, dass ICOS eine wichtige Rolle in der Ausbildung der Th1 Antwort gegen Mtb spielt. Wir infizierten WT und ICOS-/- Mäuse mit Mtb, um ein detailiertes Bild der Kinetik und der Art der T …
-
Immunbiologie hepatischer Natürlicher - Killer T- (NKT-) Zellen
… CD106) und kostimulatorischer (CD40, CD154, ICOS-L) Moleküle auf beiden Zelltypen. Des Weiteren zeigte sich, dass das ICOS/ICOS-L Interaktion für die Toleranzinduktion von CD8+ T - Zellen durch LSEC notwendig ist. Da ein Teil der NKT - Zellen in vivo konstitutiv ICOS exprimieren, legt dies …
-
The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease
… for GVHD is immunosuppressive drugs such as corticosteroids, which may result in many side effects including the loss of the beneficial graft-versus-leukemia (GVL) effect and increased infection rates. However, GVHD-specific drugs have yet to be implemented. Here we show that by targeting on a …
-
Agile methodologies and blockchain development
… on blockchain are the Initial Coin Offerings (ICOs). An ICO is an innovative way to raise funds and launch a startup. It is also an opportunity to take part in a project, or in a DAO (Decentralized Autonomous Organization). This fund-raising tool contains however some critical issues, such as …
-
The Design and Development of Guidelines for Interactive Course Organizers
… grounded guidelines to design and develop of ICOs. It is anticipated that these guidelines can assist course developers and instructional designers in designing ICOs. This study employed a design and developmental research methodology with four phases: analysis, design, development and …
-
Exhaled breath analysis using laser absorption spectroscopy
… off-axis integrated cavity output spectroscopy (ICOS) was developed to simultaneously measure exhaled NO and CO2. Using the Bland-Altman method, the ICOS platform was found to be in good agreement with two commercial gas sensors---a chemiluminescent analyzer for NO and a non-dispersive infrared …
-
Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma
… molecules PD-1 and inducible costimulator (ICOS); and the transcription factor Bcl-6. The TFH-cells appeared to be localized in several subsets of T-cell lymphomas. However, their localization in cutaneous T-cell lymphomas has been rarely described. In this study, the clinical features, …
-
Decomposition of Urban CO2 Fluxes into Fossil and Biogenic Components using a novel Relaxed Eddy Accumulation System
… The REA system, developed within the ICOS (Integrated Carbon Observation System) Cities project, selects air based on a 20 Hz vertical wind signal into an upwind and a downwind sample, allowing for the first time 14CO2-based decomposition of CO2 fluxes into fossil and biogenic …
-
La Politica Linguistica Y Educacional en El Ecuador. (Spanish Text)
… segregados y marginados en terminos pol(')iticos, educacionales, lingu(')isticos, sociales y econom-icos. Los gobiernos y las instituciones educacionales, para mejorar la infraestructura de los grupos ind(')igenas, han tratado de implementar programas educacionales. Estos programas casi …
-
Emerging stable isotope techniques in hydrothermal research: new methods applied to carbonates and hydrous minerals in ore deposits and geothermal fields
… Integrated Cavity Output Spectroscopy (TD-OA-ICOS) system. The δ2H methodology presented is equal to isotope ratio mass spectrometry in terms of speed and precision, but considerably lower in cost. This work represents the first hydrogen isotope measurements made by a laser spectroscopy system …
-
THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE
… B7-1,2/CD40 rather than co-inhibitory ICOS-L/PD-L1 and, following their transit to their LNs, evoke a T effector instead of a tolerogenic response. Consistent with this, a.c. pre-injection or oral pre-feeding of ovalbumin (ova) in WT mice and in WT chimeras possessing …
-
Ανασκόπηση της χρησιμότητας του CT calcium score σε ασθενείς με καρκίνο που υποβάλλονται σε δυνητικά καρδιοτοξικές θεραπείες
… του CAC score με τη στρωματοποίηση HFA-ICOS ως βάση για βελτιστοποιημένη και εξατομικευμένη φροντίδα καρδιο-ογκολογίας. Ωστόσο, η απουσία τυχαιοποιημένων κλινικών δοκιμών αποτελεί τον κεντρικό περιορισμό της διαθέσιμης βιβλιογραφίας.
-
Essays in financial economics
… yet to be developed that are issued through ICOs and traded on crypto-exchanges. I demonstrate the presence of a numeraire effect in the pricing of these tokens and present evidence that it is driven by a combination of group thinking and representativeness bias. Investors mistakenly …
-
Factors influencing the development of protective and pathological responses to Trichinella spiralis infection
… thesis also demonstrated that co-stimulation via ICOS and OX40 can modulate the development of Th2 responses and the development of T. spiralis induced enteropathy and mastocytosis. The failure of TNFα/LTα -/- mice to expel T. spiralis from the small intestine despite developing a more severe …
-
Molekulare und funktionelle Analyse von Lymphocyten aus Patienten mit primären Immundefizienzerkrankungen
… letzten Monaten erstmalig genetische Defekte (ICOS, BAFF-R, TACI) entdeckt, die das Antiköpermangelsyndrom verursachen. CVID umfasst insofern eine heterogene Gruppe von Immundefekten. <br>Im Rahmen dieser Arbeit konnte die gestörte Expression des BAFF-Rezeptors, sowie Defekte im …
-
Sea surface distribution of nitrous oxide and methane in European shelf seas and the Atlantic Ocean
… using Integrated Cavity Output Spectrometry (ICOS, Los Gatos) during the D366 (NW European shelf seas, June/ July, 2011) and Atlantic Meridional Transect 22 (Atlantic Ocean, October/November, 2012) cruises. Interpretation of the N2O and CH4 datasets revealed that shelf seas produced a greater …
Page 1 of 2