Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"ICLs."”.
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
… shown to resolve DNA inter-strand crosslinks (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen generated mono-adducts (MAs) and three-stranded DNA ICLs was previously described and recently NEIL3 from Xenopus laevis was reported to repair psoralen generated MAs …
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Understanding of Intrinsic Sources of DNA Damage that Drive Human Disease: A Foray into the Study of DNA Interstrand Crosslinks and Genome-Embedded Ribonucleotides
… DNA damage: 1) interstrand crosslinks (ICLs) formed by DNA damaging aldehydes and 2) genome-embedded ribonucleotides. The clinical pathologies arising in the setting of the improper removal or repair of ICLs or genome-embedded ribonucleotides are diverse. A failure to remove ICLs in …
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Investigating the role of protein ubiquitylation in the maintenance of genome stability
… DNA lesions, such as interstrand crosslinks (ICLs). The importance of HR for maintaining genome stability is underscored by the observation that loss-of-function mutations in HR factors are commonly seen in human cancers. In this thesis, I report the use of a key hallmark of HR-deficient …
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New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… genomic stability: DNA interstrand crosslinks (ICLs), and the expansion of trinucleotide repeats. ICLs are highly deleterious lesions that disrupt replication, are destructive to dividing cells, and are extremely toxic to the hematopoietic system. The replication-dependent Fanconi anemia (FA) …
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Modulated Functions of The Fanconi Anemia Core Complex
… hypersensitivity to DNA interstrand crosslinks (ICLs), suggesting that FA genes play a role in ICL repair. Fanconi anemia core complex (including A, B, C, E, F, G, L, FAAP20, and FAAP100) activates the Fanconi pathway by providing the essential E3 ligase activity for FANCD2 mono-ubiquitination. …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… play a significant role during the repair of ICLs and they function at multiple repair steps. Here, we assessed the contributions of FANCD2/FANCI-Associated Nuclease 1 (FAN1) to the repair of ICL lesions and studied the consequences of its deficiency, which results in rare chronic kidney …
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Brazil’s Soy Moratorium: Current Expansion Capacities, Extension to the Cerrado, and Increasing Compliant Production
… integrated-crop-livestock systems with soy (ICLS) onto established pasture. We find 18.0 Mha of additional remaining eligible area in the Amazon and a hypothetical 67.9 Mha in the Cerrado, of which 81.0% and 62.3%, respectively, are estimated to be suitable for soy production. Utilizing all …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… in the repair of DNA interstrand crosslinks (ICLs). More recently, two DNA glycosylases (endonuclease VIII – like 1 & 3 [NEIL1 & NEIL3]) that excise oxidised bases from DNA, thus initiating base excision repair, have been found to participate in the resolution of psoralen induced ICLs. …
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Investigating the role of NEIL3 in colorectal cancer resistance to oxaliplatin
… (apurinic) site-induced interstrand crosslinks (ICLs), thus prompting these studies into the possible contribution of NEIL3 to oxaliplatin resistance in CRC treatment via its ability to unhook ICLs. Previous studies have also reported the overexpression of NEIL3 in CRC tissues and associated it …
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Characterization of optically pumped interband cascade lasers.
… spontaneous emission for further improvement of ICLs. Some ICL samples were also electrically pumped and light-current (output light vs. injected current) curves were measured, allowing a determination of the threshold current density and characteristic temperature of the devices for temperatures …
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Structural and Biochemical Investigation of Fanconi Anemia Pathway Activation
DNA interstrand-crosslinks (ICLs) are covalent links between complementary DNA strands that prevent their separation, interfering with fundamental cellular processes such as DNA replication and transcription. Consequently, these DNA lesions are highly toxic and the inability to repair them results …
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Elucidation of Snm1B Function
… from agents that induce interstrand crosslinks (ICLs), lethal lesions that covalently attach the opposite strands of DNA together. To elucidate how Snm1B performs these functions I performed a yeast two-hybrid screen to identify proteins binding to the C-terminus of Snm1B. From this screen I …
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Microbiome Metabolism in the Rumen of Bovine Grazing Toxic Tall Fescue and in Stored Dairy Manure
… system (integrated crop-livestock system; ICLS) that aims to reduce the environmental impacts of agricultural practices while maintaining the productivity and profitability. The use of one step's byproducts by another is a crucial component of this practice. The continuity and effectiveness …
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Molecular Recognition At Dna Damage Sites
… hypersensitivity to DNA inter-strand crosslinks (ICLs), but not to whole body irradiation. Instead, Merit40 mutation exacerbated ICL induced chromosome instability in the context of concomitant Brca2 deficiency. These findings define specific functional interactions between the RAP80 complex …
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Environmental Impact of Pasture-Based Milk Production in Integrated Crop-Livestock Systems
… an organic integrated crop-livestock system (ICLS) under low-input conditions, conducted over two years (2021–2023) at the Lindhof experimental farm of Christian Albrecht University Kiel, focusing on enteric methane (CH₄) emissions, carbon (C) dynamics, and nitrogen (N) losses. The first …
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Caretaker-Gen-Syndrome
… gegenüber DNA-„interstrand crosslinks“ (ICLs) aus, zu deren Behebung u.a. die homologe Rekombinationsreparatur (HRR) eingesetzt wird, bei der das RAD51(A)-Protein eine zentrale Rolle spielt. Aufgrund schwacher Homologien werden 5 weitere Proteine (RAD51B, C, D, XRCC2 und 3) der …
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Inverse Compton Light Source: A Compact Design Proposal
… for a compact Inverse Compton Light Source (ICLS) which is capable of producing high-quality X-rays by colliding an electron beam and a high-quality laser. It is only in recent years when both SRF and laser technology have advanced enough that compact sources can approach the quality found at …
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Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution
… roles in repair of DNA interstrand crosslinks (ICLs). In addition to its role in ICL repair, the SLX4 complex has the relatively unusual property of being able to cleave efficiently four-way DNA structures called Holliday junctions (HJs) in vitro. At the outset of this study a major unanswered …
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Molecular Characterization of Novel Mutations in Fanconi Anemia Patients
… a function also required during the repair of ICLs. Each sibling inherited a LOF BRCA2 mutation in trans to a missense mutation of the BRCA2 DNA binding domain. Evaluation of BRCA2 DNA binding domain mutations revealed that this domain is important for replication fork protection, and to a …
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Caracterização molecular dos genes PSO2 e PSO4 de Saccharomyces cerevisiae envolvidos na reparação do DNA : análise funcional e identificação de interações proteína-proteína
… à tratamentos com outros agentes indutores de ICLs, indicando que o metabólito natural ACA pode causar danos do tipo ICL em S. cerevisiae. A utilização do sistema dois-híbridos permitiu isolar partes de proteínas codificadas por nove diferentes genes, entre eles a proteína quinase Pak1p, um …
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