Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ICGC"”.
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… from the International Cancer Genome Consortium (ICGC) and in-house targeted sequencing of 13,736 UCEs and demonstrate that ncUCE somatic alterations are pervasive. Using a genome-wide multiplexed CRISPR knockout screen in colorectal cancer (CRC) cell lines, we show that the loss of several …
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Estimating telomere length from whole genome sequencing data
… projects. The first application, to the Prostate ICGC UK cohort, unveils hitherto uncovered associations between telomere length and previously identified molecular subtypes as well as cancer stage. In the second application, to the NIHR BioResource - Rare Disease cohort, we discover a previously …
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Integrative Biomarker Identification and Classification Using High Throughput Assays
… comprehensive projects such as (TCGA) and (ICGC) which systematically characterize the molecular fingerprints of cancer cells using gene expression, methylation, copy number, microRNA and SNP microarrays as well as next generation sequencing assays interrogating somatic mutation, insertion, …
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Transcription Factor-Centric Approaches to Identify Regulatory Driver Mutations in Cancer
… from the International Cancer Genome Consortium (ICGC), and identified potentially dysregulated genes whose regulatory mutations could trigger significant TF binding changes. Notably, the genes identified by us are different from the ones prioritized by recurrence-based approaches. However, most …
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Patterns of somatic genome rearrangement in human cancer
… classification and downstream analysis. The ICGC project on the Pan-Cancer Analysis of Whole Genomes provides an unprecedented opportunity to analyse somatic SVs at base-pair resolution in more than 2500 samples from 30 common cancer types. In this thesis, I build on a recently developed SV …
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Compositional models for mutational signature analysis
… two independently labeled cohorts of TCGA and ICGC samples. Outlook: This thesis introduces the use of compositional models to study the dynamics of mutational signatures in the comparison of two groups of samples, and they can be readily applied to several other regression settings in this …
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Targeting the Urokinase Plasminogen Activator System Combined with Chemotherapy-a Potentially Novel Therapeutic Approach for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is recognised as an exceptionally aggressive form of cancer, notorious for its limited treatment options, resistance to chemotherapy, and consequent poor prognosis. This dissertation comprehensively explores the potential of targeting the urokinase …