Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 103 for “"ICAM-1"”.
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Functional analysis of ICAM-1 : LFA-1 interaction in cell adhesion
… at exploring the use of a soluble form of ICAM-1 to inhibit cellular immune responses, which in general rely heavily on the interaction between the counter receptors ICAM-1 and LFA-1, and aimed secondly at studying the mechanisms regulating ICAM-1:LFA-1 mediated cell adhesion. Functional …
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
Engagement of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells (ECs) by anti-ICAM coated beads generates vesiculization via cell adhesion molecule (CAM)-mediated endocytosis, a clathrin-/caveolae-independent pathway involving Na+/H+ exchanger 1 (NHE1). ICAM-1 itself plays a key role …
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Cyclooxygenase-2 is Associated with Cadmium-induced ICAM-1 Expression in Brain Endothelial Cell
… Recently, we have reported that Cd stimulates ICAM-1 expression via NF-kB activation in bEnd.3 cerebrovascular endothelial cells. And also, we observed Cd induces cyclooxygenase-2 (COX-2) expression, and thereby prostaglandin E2 (PGE₂) production in bEnd.3. Based on the previous report that …
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Expression of ICAM-1, MHC-1 and B7 surface molecules in canine primary appendicular osteosarcoma
… primary appendicular osteosarcomas express ICAM-1, MHC-1 and B7 molecules which are critical in eliciting optimum immune response. Cell lines and tissue sections (frozen and paraffin-embedded, formalin-fixed tissues) of dogs with osteosarcoma were analyzed using fluorescence microscopy, flow …
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
… including Intracellular adhesion molecule-1 (ICAM-1), which are responsible for the microglial activation using immortalized BV2 microglial cell line. After seeding in the plastic, BV2 cells showed their morphological changes, from the round shape to bipolar or multipolar (spread) shape, …
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Perfil plasmático da ICAM-1 e da VCAM-1 no pós-operatório cardíaco de lactentes submetidos à circulação extracorpórea
… de defeitos cardíacos congênitos torna-se criticamente doente durante o primeiro ano de vida e necessita tratamento cirúrgico. No entanto, durante cirurgias cardíacas, ocorre uma resposta inflamatória intensa desencadeada pelo período de circulação extracorpórea (CEC), o que provoca disfunção …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… T cells. Additionally, I identified a role for ICAM-1 in promoting homeostatic proliferation. Wt memory CD8 T cells displayed impaired homeostatic proliferation in ICAM-1<sup>-/-</sup> hosts but not in models of acute IL-15-driven proliferation. In this way, the role of ICAM-1 in IL-15 …
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Determining The Roles of Dendritic Cells and Icam-1 In The Transpresentation of Il-15 to Cd8 T Cells
… T cells. Additionally, I identified a role for ICAM-1 in promoting homeostatic proliferation. Wt memory CD8 T cells displayed impaired homeostatic proliferation in ICAM-1<sup>-/-</sup> hosts but not in models of acute IL-15-driven proliferation. In this way, the role of ICAM-1 in IL-15 …
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Characterization of a murine activated lymphocyte antigen (MALA-2) : the murine homologue of human intercellular adhesion molecule 1 (ICAM-1)
… the human intercellular adhesion molecule 1 (ICAM-1), as well as human ICAM-2, human ICAM-3, and murine ICAM-2. Screening of genomic libraries yielded a partial genomic clone (4.0 kb ), containing five 3'exons and a pseudo exon. The five exons are common to both cDNAs and have consensus splice …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type and experimental conditions. Furthermore, the effect of PGE2 on ICAM-1 expression in cerebrovascular endothelial cells is mostly unknown. In this study, it was investigated the roles of PGE2 in the …
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
… for CD18 is intercellular adhesion molecule-1 (ICAM-1). In the pulmonary circulation, PMNs emigrate by either a CD 18-independent or CD 18-dependent mechanism. The objective of this thesis was to quantitate and compare the surface expression of L-selectin, CD 18, and ICAM-1 during …
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Regulation of LFA-1 on T cells by phosphoinositide signalling
… binds Intercellular Adhesion Molecule 1 and 2 (ICAM-1 and ICAM-2) expressed on endothelial cells and antigen presenting cells. LFA-1 affinity for ICAM is increased following chemokine and T cell receptor (TCR) engagement by inside-out signalling. This process coordinates T cell migration, …
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Dynamic Assessment of Nk Cell Interactions With Pediatric Tumor Cells to Predict Response to Immunotherapy
… IFNγ cause significant upregulation of PD-L1, ICAM-1, and MHC-class I, but this upregulation varies widely between the cell lines. Modeling of the data suggests that the effect of IFNγ on NK cell-mediated tumor lysis is mostly dependent on relative changes in MHC-class I and ICAM-1 expression. …
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Functional Significance of the Upregulation of Adhesion Molecules on Irradiated Endothelial Cells
… this process, particularly, E-selectin and ICAM-1, which are inducible adhesion molecules. E-selectin is involved in the initial tethering and rolling steps of the adhesion cascade while ICAM-1 appears to be involved in the latter steps. We have hypothesized that in response to irradiation, …
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The Role of Inflammation in the Early Radiation Response
… (TNF) and intracellular adhesion molecule-1 (ICAM-1) in the radiation response; evaluate the role of a novel anti-inflammatory agent as an interventional therapy to limit the radiation-induced inflammatory response; begin to characterize the acute damage following radiation using the shift in …
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Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
… expression of intercellular adhesion molecule-1(ICAM-1) in brain endothelial cells remains unexplored. In this study, we examined the effect of IBC on ICAM expression and leukocyte adhesion in bEnd. 3 cells and explored the possible mechanisms therein involved. IBC significantly down-regulated …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
… western blotting analysis. In nervous system, ICAM-1 mRNA was expressed in astrocytes and microglia. NCAM mRNA was expressed in astrocytes as well as neurons and CHL1 mRNA is expressed in astrocytes, microglia and neurons. And L1 mRNA was expressed in neurons. As the result of the expression of …
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Regulation of β2-integrins by signalling pathways and cytoplasmic interacting partners
… B cell adhesion to the LFA-1 integrin ligand ICAM-1 (Intracellular Adhesion Molecule 1) under shear stress. In contrast, integrin-mediated adhesion of CD4+ and CD8+ T cells was not affected by Akt inhibition under shear flow conditions, indicating that adhesion in different lymphocyte subtypes …
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