Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 211 for “"IBD"”.
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The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome
Inflammatory bowel disease (IBD) is a group of immune-mediated autoinflammatory disorders, primarily manifesting in the gastrointestinal tract. Affecting millions of people around the world, IBD has a severe impact on patients’ quality of life. Several pharmacologic treatments have been available …
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The lived experiences of family planning for women with inflammatory bowel disease (IBD)
Inflammatory Bowel Disease (IBD) affects 1 in 400 people in the UK, with a prevalence of 397 per 100,000 among women, many of whom are of childbearing age. Women with IBD report heightened pregnancy-related anxieties, and their family planning decisions are complex and influenced by both medical …
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Towards the development of a multicomponent, nanoscale oral vaccine delivery system targeting infectious bursal disease (IBD)
… scale, is infectious bursal disease virus (IBDV). Vaccination against IBDV is sub-optimal and difficult to deliver. Therefore it has been highlighted as a key area for the development of an oral vaccine. A highly conserved capsid protein from IBDV (VP2) was identified, and sub-cloned into a …
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Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
Inflammatory bowel disease (IBD) is an umbrella term for disorders involving chronic inflammation of the gastrointestinal tract, with over 6 million cases reported worldwide. 320 IBD risk loci have been identified for this disease, however, the role of many of these risk loci in the pathogenesis of …
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LSRP: Defence styles, alexithymia, illness perceptions, and HRQOL in IBD. Systematic lit: Neurodegenerative diseases and third wave therapies
… alexithymia, illness perceptions, and HRQOL in IBD<br/>Background/aims: The role of psychological factors in the development and progression of Inflammatory Bowel Disease (IBD) is not completely understood. Several studies have suggested that defence styles, alexithymia and illness perceptions …
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Satisfaction of Individuals Living with Inflammatory Bowel Disease and Gastroenterology Care Providers with Telephone Care
… People living with inflammatory bowel disease (IBD) require regular medical follow-up, which could be challenging for individuals living in rural areas and those who have limited access to specialized care. Telephone care (TC) could improve health care by increasing access to specialized care …
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Improving quality of care in inflammatory bowel disease: treatment targets and body composition
… care for people with inflammatory bowel disease (IBD) aims to modify the course of disease and normalise quality of life (QoL). Treatment directed at objective inflammation has been shown to improve outcomes in IBD, yet represents a paradigm shift for clinicians trained to manage symptoms alone. …
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… two major forms of Inflammatory Bowel Disease (IBD), are multifactorial autoimmune diseases caused by an abnormal immune response to gut microbiota in genetically susceptible individuals resulting in dysregulation of type 1/2/17 immune responses. CD90+ (myo)fibroblasts (CMFs) are abundant innate …
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Mitochondrial damage-associated molecular patterns (DAMPs) in inflammatory bowel disease
Background The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD) are chronic relapsing inflammatory disorders which have a rising incidence and cause significant morbidity. There are currently several treatment options with many more in the drug pipeline, but there …
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Ethnic Variations of Pediatric Inflammatory Bowel Disease Within Canada
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with highest prevalence in the Western world. Up to twenty-five percent of those who develop IBD are diagnosed in their childhood or adolescent years. Recent temporal trends in adult and pediatric …
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Identification of bacteria-regulated mechanisms for the pathogenesis of inflammatory bowel diseases (IBD) and development of upconverting nanoparticle (UCNP) luminescence imaging for the monitoring of gut bacteria
Inflammatory bowel disease (IBD) is a chronic inflammatory state of the gastrointestinal tract, including two inflammatory conditions Crohn’s disease (CD) and ulcerative colitis (UC). The environment, the gut microbiota, the genetic make-up and the immune response are believed to contribute to the …
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Defining Resilience in Young People with Inflammatory Bowel Disease: A Theory Informed Approach
<p>Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal illness for which there is no existing cure. There is significant literature documenting the increased likelihood of adverse biopsychosocial outcomes in young people with IBD (e.g., Greenley et al., 2010); however, many individuals …
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity
Inflammatory bowel disease (IBD) is characterized by dysregulation of the immune system, driven in part by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and act to polarize M1 macrophages at the site of …
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Subject positions of British South Asian women with inflammatory bowel disease: a Foucauldian discourse analysis
The prevalence of inflammatory bowel disease (IBD) among British South Asians (BSA) is increasing. Evidence suggests that people of BSA background are more likely to develop IBD than white Europeans. Research on women with IBD is primarily focused on reproduction, which limits our understanding of …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
Inflammatory bowel disease (IBD) is an abnormal immune response to the gut microbiome causing chronic debilitating pain in genetically susceptible people. The development of effective therapies for this condition is hampered by a poor understanding of its complex aetiology. Progress in this area will …
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Quality of life and coping in children and adolescents with inflammatory bowel disease
Inflammatory Bowel Disease (IBD) is a chronic disease with pehods of remission and relapse, as inflammation occurs in the gastrointestinal tract causing symptoms such as diarrhoea, fatigue, abdominal cramps and loss of appetite. This work aimed to validate an instrument to measure quality of life …
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Investigating a Mitochondrial Fission Inhibitor as a Therapeutic for Inflammatory Bowel Diseases
… the pathogenesis of inflammatory bowel disease (IBD). The current study utilized the P110 peptide drug, a selective inhibitor of mitochondrial fission, to investigate the relationship between mitochondrial dynamics and colitis. First, the functionality of the P110 peptide was verified in T84 …
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Defining Microbiome Stability in First-Degree Relatives of Inflammatory Bowel Disease Patients
… health and disease. Inflammatory bowel disease (IBD) is a chronic inflammatory relapsing condition with no known cure, requiring lifelong medication and often surgical intervention, significantly diminishing quality of life. IBD is intrinsically linked to the gut microbiome with well documented …
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Methods Development in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a disease that is classified into two subtypes: ulcerative colitis (UC) and Crohn’s disease (CD). Symptoms can range from mild discomfort to requiring surgical intervention and affects approximately 1-in-200 adults in America alone, with global incidence rates …
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