Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"IAPs"”.
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Investigating the Role of the Inhibitor of Apoptosis Proteins (IAPs) in Metastasis Formation
Inhibitor of apoptosis proteins (IAPs) constitute a conserved family of molecules, which regulate both apoptosis and receptor signalling. They are often deregulated in cancer cells and represent potential targets for therapy. In my work, I investigated the effect of IAP inhibition <i>in vivo</i> to …
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Influence of the Negative IAPS and Method of Hemispheric Presentation on Performance on the Affective Auditory Verbal Learning Test
… from the International Affective Picture System (IAPS), negative or neutral and two gender conditions, male and female. Experiment I was used to verify that the IAPS results in an emotional response. Heart rate (HR) and skin conductance level (SCL) were measured during IAPS presentation. Emotion …
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The investigation of microbial-intestinal epithelial cell interactions in the gut and their effects on inhibitor of apoptotic proteins (IAPs)
… prevention of cytokine-induced apoptosis. IAPs were assessed both in vitro and in vivo and HIAP1 and HIAP2 were determined to be involved in this process. This is consistent with NF-kB activation by Lp299v. Probiotics may confer exogenous effects on IECs to elaborate protective mechanisms …
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The Development of Low-Cost Remote Sensing Technology to Monitor Invasive Alien Plant Species: The Case of Japanese Knotweed
Invasive Alien Plant Species (IAPS) are becoming more resilient to global warming. Their effects alter biodiversity causing harm to native organisms and plants. Their early detection followed by a quick response are more helpful and cost-effective than controlling their spread. Freely available …
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Mechanisms of epiallelic variation in mouse
… TEs. Over 50 constitutively variably methylated IAPs (VM-IAPs) have been identified in the C57BL/6J mouse strain. This thesis investigates the mechanisms driving interindividual methylation variation at TEs in the C57BL/6J mouse strain. First, I deconvolute a genetic model of abnormal folate …
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… histone marks. Intracisternal A-particles (IAPs) are evolutionarily young murine-specific endogenous retroviruses (ERVs). Some are capable of retrotransposition and many harbour regulatory sequences with the potential to influence host gene expression. Previous work has shown that, at the …
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Aliens in the nursery : assessing the awareness and attitudes of Cape Town nursery managers in regard to invasive species regulations
… and spread of invasive alien plants (IAPs). In recognition of this, the South African government has recently enacted a new set of Alien and Invasive Species regulations, under the National Environmental Management Biodiversity Act (NEMBA), that are intended, in part, to improve …
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Regulation of Apoptosis by XIAP Ubiquitin- Ligase Activity
… of cancer. Inhibitor of Apoptosis Proteins (IAPs) can bind to and inhibit caspases, the key executioners of apoptosis. Because IAPs are frequently over-expressed in human tumors, they have become major pharmacological targets for developing new cancer therapeutics. Many IAPs contain RING …
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Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
Inhibitor of apoptosis proteins (IAPs) regulates apoptosis by inhibiting caspases. This inhibition mechanism is an escape from death used by some human cancers. Second mitochondria-derived activator of caspases (Smac), a mitochondria-released protein during apoptosis, binds to IAPs BIR domains with …
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Cellular Stress and Effects on Mitochondrial DNA: An Assessment of Stress Reduction & Protective Effects
… with the International Affective Picture System (IAPS). We hypothesized that participants exposed to mindfulness meditation (MM) instruction would demonstrate lesser increases in cf-mtDNA levels and negative mood states compared to controls. Methods: Thirty-five females (18-30 years) were …
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Diverse functions for intern associated proteins in Drosophila adult muscle
… proteins (integrin-associated proteins, IAPs). Integrins are required for muscle attachment and in Drosophila, loss of integrins and several IAPs results in embryonic lethality and muscle detachment. However, the IAPs FAK, RSU1, tensin, vinculin and zyxin are not required for viability or …
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Viability analysis for investing in ecological infrastructure to secure water supply: A case study of South Africa
… benefit human well-being. Invasive alien plants (IAPs) are degrading catchment areas which negatively impacts delivery of hydrological ecosystem services. Clearing IAPs is considered a catchment conservation intervention that preserves these services. This study used South Africa as a case study …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… metastable epialleles, or variably methylated IAPs (VM-IAPs), and are widely cited as the best examples of mammalian epigenetic inheritance. A recent screen in the C57BL/6J mouse strain identified over 100 candidate VM-IAPs providing novel insights into metastable epialleles. In this thesis, I …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… epialleles. I have identified over 100 murine IAPs with properties of metastable epialleles. Like Avy, each exhibits a stable epigenetic state within an individual but epigenetic variability between individuals. Methylation levels are locus-specific within an individual, suggesting cis-acting …
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A psychotherapeutic service for women in an independent approved premise: a case study
… Women are frequently referred toward APs/IAPs to support their reintegration into the broader community. The main goal is to foster women’s self-sufficiency, discourage criminal behaviour and prevent recall to prison. Communities like APs/IAPs often go unnoticed yet play an integral role …
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Emotional Response to Auditory and Visual Stimuli
… is the International Affective Picture Systems (IAPS). An additional set of stimuli, the International Affective Digital Sounds (IADS), was created to be an auditory equivalent of the IAPS. The present study sought to compare the emotional response (measured with Heart Rate, Skin Conductance, and …
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Modelling the spatial distributions and water use of Mauritius thorn (Caesalpinia decapetala) and river red gum (Eucalyptus camal dulensis) using remote sensing and geographic information system techniques in the Vhembe Biosphere Reserve
… at the global and local levels. Water is used by IAPS using remotely sensed Evapotranspiration (ET) derivatives from the Food and Agriculture Organisation’s (FAO) Water Productivity Open-access Portal (WaPOR). ET products as a proxy for plant water focusing on E. camaldulensis and C. decapetala in …
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
… adenovirally-mediated overexpression of the IAPs resulted in protection against QA-induced degeneration. The goal of the third study was to determine whether neurons saved by overexpression of the IAPs were still functional. In a third study, animals were intrastriatally injected with …
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IAP antagonist Grim mediates cell death through divergent pathways
… or developmental cues, inhibitor of apoptosis (IAPs) can prevent caspase-mediated cell death, not only through direct binding and inhibition, but also by directly ubiquitinating caspases, which inactivates them or targets them for degradation. In flies and mammals, cell death is facilitated or …
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Effect of Depression on Attention via Mood Induction in a Healthy Population
… in the International Affective Picture Set (IAPS). Participants were psychology students recruited from La Sierra University. Participants completed a word task that intended to induce a sad or neutral mood. The Positive and Negative Affect Scale (PANAS) was used to evaluate the efficacy of …
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