Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"IAP"”.
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IAP antagonist Grim mediates cell death through divergent pathways
… or developmental cues, inhibitor of apoptosis (IAPs) can prevent caspase-mediated cell death, not only through direct binding and inhibition, but also by directly ubiquitinating caspases, which inactivates them or targets them for degradation. In flies and mammals, cell death is facilitated or …
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Solution structure and biochemistry of an intramembrane aspartyl protease (IAP)
… Through structure-function analysis of a model IAP from the archaeon Methanoculleus marisnigri JR1 (mIAP), the catalytic motifs and substrate gating motifs were found to influence the catalytic efficiency but not the processivity and specificity of cleavages. Both positional and chemical …
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Pre-clinical evaluation of inhibitors of apoptosis protein (IAP) antagonists in colorectal cancer
… important role. Inhibitor of apoptosis proteins (IAPs) are capable of converting TNFα signalling from a pro-apoptotic to a pro-survival and pro-inflammatory signal. Overexpression of IAPs is associated with chemoresistance and poor prognosis in CRC. Consequently, IAPs are an attractive target for …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… antagonists of the Inhibitor of Apoptosis (IAP) family of proteins. Binding of SMCs to the IAPs results in the sensitization of cancer cells to apoptosis in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in …
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A Study of Raised Intra-abdominal Pressure and the Abdominal Compartment Syndrome in Liver Intensive Care
… in intra-abdominal pressure (IAP) measurement has increased significantly, with evidence of its deleterious effects demonstrated on every organ. Despite the volume of publications – several assumptions relating to the measurement of IAP remain unproven and there is a paucity of …
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Baculovirus inhibitors of apoptosis
… this gene with reported inhibitor of apoptosis (iap) sequences identifted a RING finger and baculovirus IAP repeat (BIR) conserved in all the members of this protein family. The predicted sequence of the HzSNPV iap was found to be 42% identical to that of Orgyia pseudosugata (0p) MNPV iap and 39% …
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ABDOMINAL PRESSURE PROFILING IN ADULT HORSES
Measurement of intra-abdominal pressure (IAP) is essential for documentation and monitoring of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS). IAH and ACS are two linked conditions significantly associated with morbidity and mortality in critically ill humans. …
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Incremental Design Migration Support in Industrial Control Systems Development
… to ICS design: an Interface Abstraction Process (IAP). IAP helps in incremental migration from a modeling environment to a real physical environment by supporting intermediate design versions. Implementation of the IAP is simple and independent of control system complexity. Early error …
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… histone marks. Intracisternal A-particles (IAPs) are evolutionarily young murine-specific endogenous retroviruses (ERVs). Some are capable of retrotransposition and many harbour regulatory sequences with the potential to influence host gene expression. Previous work has shown that, at the …
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Immunoprotective effects of lipopolysaccharide detoxification by a novel microbial-derived alkaline phosphatase
… reductions in intestinal alkaline phosphatase (IAP), which has biological roles including detoxifying LPS in the intestinal lumen and maintaining an alkalotic pH to modulate gut microbiota. IAP is a homodimeric enzyme that catalyzes the release of an inorganic phosphate from the lipid A moiety …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… the murine-specific intracisternal A particle (IAP) elements. To prevent their mobilisation and suppress the function of the TE- encoded regulatory sequences, TEs are generally targeted by repressive histone modifications and DNA methylation. The Avy allele results from an IAP insertion into the …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… of cancer, of which the inhibitor of apoptosis (IAP) family of proteins plays an important role. It has also been shown that cancer cells secrete vesicles called tumor exosomes (TEX) which are loaded with bioactive molecules which strongly influences the tumor microenvironment. Both protein and …
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Genetic and Biochemical Analyses of the Necessity for Caspase Activation by the CED4-Domain Proteins, APAF-1 and DARK
… Recombinant Grim protein was shown to antagonize IAP-mediated caspase inhibition in vitro. Peptides corresponding to the conserved Amino-termini of the reaper, grim and hid genes could compete for a binding site also used by the mammalian anti-IAP protein SMAC to block IAP-caspase interaction. …
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A psychotherapeutic service for women in an independent approved premise: a case study
… in a female-only Independent Approved Premises (IAP) necessitates understanding their needs to strengthen its efficacy. This case study explored, through a reflexive lens, what providing an on-site psychotherapeutic service means to residents who have not previously engaged with the service and …
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Reliability of Urinary Bladder Pressure Measurement in Critical Care
… of the study: Intra abdominal pressure (IAP) theoretically may be a predictor of enteral nutrition tolerance (EN). Urinary bladder pressure (UBP) is the gold standard for estimating IAP. Current recommendations for UBP measurement (UBPM) calls for the instillation of normal sterile saline …
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Investigating the Role of the Inhibitor of Apoptosis Proteins (IAPs) in Metastasis Formation
Inhibitor of apoptosis proteins (IAPs) constitute a conserved family of molecules, which regulate both apoptosis and receptor signalling. They are often deregulated in cancer cells and represent potential targets for therapy. In my work, I investigated the effect of IAP inhibition <i>in vivo</i> to …
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Indoor air pollution and environmental tobacco smoke exposure in a South African birth cohort study
… Environmental exposures to indoor air pollution (IAP) or tobacco smoke are important risk factors for childhood respiratory disease. Despite increased electrification, many communities in LMIC rely on alternate fuel sources for household cooking or heating. The impact of antenatal or postnatal …
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The impact of solid cooking fuels on the health of rural South African households
Indoor Air Pollution (IAP) from the combustion of solid cooking fuels has been proven to adversely affect the health of household residents. Those most affected by IAP are the poorest and most vulnerable members of society, specifically poor women and children residing in rural households. This …
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Qualitätskontrolle von Proteinen in Mitochondrien
… matrix-AAA-protease; auch m-AAA-Protease) und IAP-1 (für intermembranespace AAA-protease; auch i-AAA) im Fadenpilz N. crassa identifiziert und charakterisiert. Die entsprechenden Gene wurden unter Verwendung von DNA-Sequenzfragmenten, die aufgrund einer ESTDatenbank bekannt waren bzw. durch …
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