Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"IACS-010759"”.
-
Oxidative Phosphorylation: A Critical Feature and Novel Therapeutic Target In Melanoma Brain Metastases
… of OXPHOS in MBM pathogenesis was tested using IACS-010759, a potent OXPHOS inhibitor currently in phase I clinical trials. IACS-010759 treatment of an RCAS-TVA mouse model of spontaneous MBM and lung metastasis significantly decreased the incidence of detectable MBMs but did not affect primary …
-
Mitochondrial Stress Signals Induce a Drug Tolerant Persister Phenotype in Triple Negative Breast Cancer Cell Models
… including inhibition of ETC complex-1 using IACS-010759. Through transcriptomic analyses, following ETC inhibition, we observed high expression of interferon signalling, which was accompanied by downregulation of 13 genes encoded within mitochondrial DNA (mtDNA). We also directly detected a …
-
Increased Oxidative Phosphorylation In An Ipsc- Derived Model of Rothmund-Thomson Syndrome Associated Osteosarcomagenesis
… We utilized the specific inhibitor of complex I, IACS-010759, and examined the nature of oxidative phosphorylation after treatment. We found significantly decreased maximal respiration and cell proliferation after treatment at physiological doses. Transcriptional changes that occurred after …
-
Cryo-EM studies of substrate and inhibitor binding to mammalian respiratory complex I
… cancers reliant on oxidative phosphorylation (IACS-010759), the structure of mouse complex I inhibited by IACS-2858 – a tighter binding derivative – was resolved to a global resolution of 3.0 Å. The inhibitor, which bears little resemblance to ubiquinone-10 (Q₁₀), occupies the entrance to the …