Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"I kappa B"”.
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Role of I Kappa B Kinase Alpha and I Kappa B Kinase Beta in the Development and Function of B and T Lymphocytes
Transcription factor NF-κB plays a key role in regulating the expression of genes involved in the control of the inflammatory and immune response. NF-κB binds to a group of inhibitory proteins, IκBs, in the cytoplasm of non-stimulated cells. Activation of NF-κB is regulated by the IκB kinase …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… lines to interrogate novel functions of the I kappa B kinases in colorectal cancer, including the relative contributions of these kinases to the activation of NF-κB signalling pathways downstream of TNFα induction. Contrary to the seminal studies in KO MEFs, IKKα appeared to make a more …
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Funktion von NF-kappa B für die Differenzierung lymphoider Zellen und die inflammatorische Aktivierung von Endothelzellen
Die Aktivität des Transkriptionsfaktors NF-kappa B wird hauptsächlich durch inhibitorische I kappa B-Proteine kontrolliert,die durch die I kappa B-Kinasen 1 und 2 phosphoryliert und anschließend degradiert werden.Dadurch werden ver-schiedene zelluläre Prozesse wie Differenzierung und Aktivierung …
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2D layout of bead based thioaptamer/aptamer selection platform for therapeutics and diagnostics
… assays, a model system is first established: NF-kappa B proteins were expressed, purified and characterized. Thioaptamer XBY6, which specifically targets NF-kappa B protein, and its natural origin, I-kappa B were synthesized and verified. Thioaptamer purification using FPLC and HPLC was also …
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Inhibition des nukleären Transkriptionsfaktors kappa B (NF-Kappa B) durch die kurzkettige Fettsäure Butyrat
… entzündlichen Prozessen ist der nukleäre Faktor kappa B (NF-kappa B) an der transkriptionellen Regulation proinflammatorisch wirkender Genprodukte beteiligt. Durch Mediatoren wie TNF alpha oder IL-1 beta wird eine nukleäre Translokation von normalerweise im Zytoplasma an inhibitorische I kappa …
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EVALUATION OF YAK-KONG SOYBEAN (GLYCINE MAX) FOR ITS PHENOLICS AND METABOLITES WITH A FOCUS ON ATHEROSCLEROSIS PREVENTION
… of VCAM-1, MCP-1 and phosphorylation of I Kappa B Kinase (IKK) in NF-B signaling pathway. In sum, YK has promising potential for further development as a functional food source targeted at atherosclerosis prevention.
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Host cell signaling in response to RSV infection
… inhibited the translocation of nuclear factor-kappa B (NF-kappa B) and interferon response factor 3 (IRF3) to the nucleus at the early phase of viral infection. In contrast, siRNA-mediated TLR3 knockdown did not affect RSV-induced NF-kappa B binding to DNA but block the activating …
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… the A2AAR can suppress activation of the NF kappa B and JAK/STAT proinflammatory signalling pathways. NF kappa B appears to be primed for activation in atherosclerosis-prone regions of the aorta indicating that suppression of NF kappa B signalling may protect against the development of …