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Showing 1 to 2 of 2 for “"Hypusine"”.
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
… of eIF5A requires the rate-limiting enzyme deoxyhypusine synthase (Dhps) to post- translationally modify a critical lysine residue which in turn produces the active form of eIF5A that functions in mRNA translation. When we generated animals with a deletion of Dhps in the pancreatic progenitor …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… occurs via two enzymatic reactions. First, deoxyhypusine synthase (DHS) transfers the aminobutyl moiety of spermidine onto the eIF5A-lysine generating deoxyhypusine which is then hydroxylated by deoxyhypusine hydroxylase to yield the final modification, hypusine. Modified eIF5A has been shown to …