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Showing 1 to 3 of 3 for “"Hypusination"”.
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… spermidine is essential for the (deoxy)hypusination of eukaryotic initiation factor 5A (eIF5A). Hypusination, a post-translational modification, occurs via two enzymatic reactions. First, deoxyhypusine synthase (DHS) transfers the aminobutyl moiety of spermidine onto the eIF5A-lysine …
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
… form, plays a role in pancreas development. The hypusination of eIF5A requires the rate-limiting enzyme deoxyhypusine synthase (Dhps) to post- translationally modify a critical lysine residue which in turn produces the active form of eIF5A that functions in mRNA translation. When we generated …
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Eukaryotic Initiation Factor 5A2 (EIF5A2) Contributes to Ovarian Tumor Growth and Metastasis
<p>Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and …