Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Hypoxic-Ischemic Encephalopathy"”.
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
<p>Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily causes neuronal and white matter injury and is among the leading cause of death among infants. Currently there are no well-established treatments; thus, it is important to understand the pathophysiology of the …
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Parents of Children Who Had Hypoxic-Ischemic Encephalopathy: A Mixed-Methods, Exploratory Study
… addressing the parents of children who had hypoxic-ischemic encephalopathy (HIE). therefore only inferences may be made as to issues of that experience affecting parents.</p> <p><strong>Purpose: The purposes of this study was to uncover the lived experiences of parents of children who had …
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Hypoxic-ischemic encephalopathy grading using novel EEG signal processing and machine learning techniques
\IEEEPARstart{H}{ypoxic-Ischemic Encephalopathy} (HIE) is a critical brain injury in newborns resulting from oxygen or blood supply deprivation during birth. Traditional diagnosis methods for HIE require specialized expertise from a trained medical professional, and immediate intervention of …
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Predicting adverse neurological outcomes in infants receiving therapeutic hypothermia for hypoxic ischemic encephalopathy
Background: Hypoxic Ischemic Encephalopathy (HIE) is a categorization of term infants with brain injury caused by a lack of oxygen and/or blood flow to the brain. Despite, therapeutic hypothermia (TH) treatment, consequences of HIE can include life-long disability or even death. Current diagnostic …
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Feeding and swallowing in neonates with Hypoxic Ischemic Encephalopathy (HIE): a descriptive study
… including intrapartum hypoxia and subsequent hypoxic ischemic encephalopathy (HIE), are the second highest cause of neonatal deaths in South Africa. For survivors, such complications may be associated with a substantial burden of impairment, including the inability to feed well and swallow …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
<p>Hypoxic events encountered during the perinatal period leading to pathologic decreases in fetal cerebral oxygen availability are detrimental resulting in neonatal hypoxic-ischemic encephalopathy (HIE). This work focused on the characterization of a rat model of neonatal HIE for use in the …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… environment during pregnancy. Perinatal hypoxic-ischemic encephalopathy is an important cause of brain injury in the newborn due to a systematic asphyxia. Our study aims to test the hypothesis that maternal hypoxia affect the organogenesis of the kidney by affecting the kidney structure …
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IN VIVO DETECTION OF DOPAMINERGIC DYSFUNCTION IN A RAT MODEL OF MODERATE INTRAUTERINE ASPHYXIA
Hypoxic-ischemic encephalopathy (HIE) is a leading cause of perinatal brain injuries worldwide. Approximately one-half of all perinatal hypoxic-ischemic brain injuries are classified as `severe', leading to death, cerebral palsy, or major sensory/motor deficits by one year of age. The remaining …
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Neuropsychological Outcome following Perinatal HIE: Utility of MR Spectroscopy
<p>Outcome following hypoxic-ischemic encephalopathy (HIE), a neurodegenerative process caused by prolonged asphyxiation during birth, can vary between minimal impairment and cerebral palsy, mental retardation, or death (30%) (McCulloch, Taylor, & Whyte, 1991). Prognosis after HIE is often …
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AI-based analysis of cerebral oxygenation in preterm and term infants
… hemorrhage (IVH) in preterm infants and hypoxic-ischemic encephalopathy (HIE) in term infants. Our findings demonstrated that features extracted from PRDs significantly outperformed traditional threshold-based approaches in predicting adverse outcomes, achieving an area under the receiver …
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Mothers who listen with more than ears: The phenomenological experience of the non-verbal communication between mothers and their child with complex cerebral palsy
… non-verbal complex cerebral palsy as a result of Hypoxic Ischemic Encephalopathy at birth. The age range of the children was not > 3 and not <16. Interviews took place on a video link, semi-structured interviews were done and the six stages of a Heuristic Inquiry were used to analyse the …
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Non-invasive Optoacoustic Monitoring of Neonatal Cerebral Venous Oxygen Saturation
… and when severe can lead to neuronal injury and hypoxic-ischemic encephalopathy (HIE) in the newborn. HIE has been reported up to 3/1000 live births with a high mortality of up to 50% and 25% of survivors developing permanent neurological disabilities. Cerebral hypoxia in neonates is a diagnostic …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated …
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The perceived barriers to timely therapeutic hypothermia treatment for neonates diagnosed with hypoxic-ischaemic encephalopathy when born outside the cooling facility within the private healthcare setting
Background Hypoxic-Ischemic Encephalopathy (HIE) is a debilitating neurological injury at birth due to a hypoxic event. The recommended treatment is therapeutic hypothermia (TH) provided at certain neonatal facilities and should commence within the treatment window of 6 hours (1). The outborn …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… in neonates the most common cause of seizures is hypoxic/ischemic encephalopathy (HIE). However, in both adults and neonates, current antiepileptic drugs (AEDs) are ineffective in 30-50% of patients, despite the availability of over 20 FDA approved AEDs with diverse molecular targets. This …
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Timing of Therapeutic Hypothermia & Short-Term Infant Outcomes
<p><strong>Background:</strong> Hypoxic-ischemic encephalopathy (HIE) can result in devastating long-term neurological morbidity and/or death. Current evidence recommends initiating Therapeutic Hypothermia (TH), as early as possible, however, research specifically describing TH timing in relation …
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Effects of Elevated Intracranial Pressure on a Cerebral Vein Model
… not result in death, it can result in severe hypoxic brain injury (HBI) and has been shown to increase the likelihood of an eventual fatality in the relationship eightfold [1]. Unfortunately, minimal quantitative biomechanical research has been performed to study strangulation injury, and …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
<p><strong>Introduction:</strong> Neonatal hypoxic-ischemic encephalopathy (HIE) arises from disrupted perinatal cerebral oxygenation and perfusion. It is a leading global cause of infant death and disability which disproportionally affects males. Like adult stroke, HIE initiates a rapid influx of …
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Η προγνωστική σημασία μιας νέας κλινικής βαθμολόγησης της εγκεφαλοπάθειας των νεογνών από περιγεννητική ασφυξία, σε συνδυασμό με τα ευρήματα άλλων εργαστηριακών εξετάσεων
… value of the diagnosis of post asphyxial encephalopathy made on the basis of the clinical symptoms, based on a modification of the description of Fenichel, in combination with imaging and other laboratory examinations. We studied 60 full-term neonates with perinatal asphyxia. Immediately …
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Neurocognitive development in children
… children and 7 children with a history of hypoxic ischemic encephalopathy (HIE) participated in the study. Early CogniTOT scores were compared with scores from the Bayley-III, and later neurodevelopmental outcomes were assessed using WPPSI-IV and NEPSY-II subscales. The results demonstrated …
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