Global ETD Search
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Showing 1 to 20 of 22 for “"Hypoxic-Ischemic Encephalopathy"”.
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
<p>Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily causes neuronal and white matter injury and is among the leading cause of death among infants. Currently there are no well-established treatments; thus, it is important to understand the pathophysiology of the …
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Parents of Children Who Had Hypoxic-Ischemic Encephalopathy: A Mixed-Methods, Exploratory Study
… addressing the parents of children who had hypoxic-ischemic encephalopathy (HIE). therefore only inferences may be made as to issues of that experience affecting parents.</p> <p><strong>Purpose: The purposes of this study was to uncover the lived experiences of parents of children who had …
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Hypoxic-ischemic encephalopathy grading using novel EEG signal processing and machine learning techniques
\IEEEPARstart{H}{ypoxic-Ischemic Encephalopathy} (HIE) is a critical brain injury in newborns resulting from oxygen or blood supply deprivation during birth. Traditional diagnosis methods for HIE require specialized expertise from a trained medical professional, and immediate intervention of …
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Predicting adverse neurological outcomes in infants receiving therapeutic hypothermia for hypoxic ischemic encephalopathy
Background: Hypoxic Ischemic Encephalopathy (HIE) is a categorization of term infants with brain injury caused by a lack of oxygen and/or blood flow to the brain. Despite, therapeutic hypothermia (TH) treatment, consequences of HIE can include life-long disability or even death. Current diagnostic …
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Feeding and swallowing in neonates with Hypoxic Ischemic Encephalopathy (HIE): a descriptive study
… including intrapartum hypoxia and subsequent hypoxic ischemic encephalopathy (HIE), are the second highest cause of neonatal deaths in South Africa. For survivors, such complications may be associated with a substantial burden of impairment, including the inability to feed well and swallow …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
<p>Hypoxic events encountered during the perinatal period leading to pathologic decreases in fetal cerebral oxygen availability are detrimental resulting in neonatal hypoxic-ischemic encephalopathy (HIE). This work focused on the characterization of a rat model of neonatal HIE for use in the …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… environment during pregnancy. Perinatal hypoxic-ischemic encephalopathy is an important cause of brain injury in the newborn due to a systematic asphyxia. Our study aims to test the hypothesis that maternal hypoxia affect the organogenesis of the kidney by affecting the kidney structure …
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IN VIVO DETECTION OF DOPAMINERGIC DYSFUNCTION IN A RAT MODEL OF MODERATE INTRAUTERINE ASPHYXIA
Hypoxic-ischemic encephalopathy (HIE) is a leading cause of perinatal brain injuries worldwide. Approximately one-half of all perinatal hypoxic-ischemic brain injuries are classified as `severe', leading to death, cerebral palsy, or major sensory/motor deficits by one year of age. The remaining …
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Neuropsychological Outcome following Perinatal HIE: Utility of MR Spectroscopy
<p>Outcome following hypoxic-ischemic encephalopathy (HIE), a neurodegenerative process caused by prolonged asphyxiation during birth, can vary between minimal impairment and cerebral palsy, mental retardation, or death (30%) (McCulloch, Taylor, & Whyte, 1991). Prognosis after HIE is often …
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AI-based analysis of cerebral oxygenation in preterm and term infants
… hemorrhage (IVH) in preterm infants and hypoxic-ischemic encephalopathy (HIE) in term infants. Our findings demonstrated that features extracted from PRDs significantly outperformed traditional threshold-based approaches in predicting adverse outcomes, achieving an area under the receiver …
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Mothers who listen with more than ears: The phenomenological experience of the non-verbal communication between mothers and their child with complex cerebral palsy
… non-verbal complex cerebral palsy as a result of Hypoxic Ischemic Encephalopathy at birth. The age range of the children was not > 3 and not <16. Interviews took place on a video link, semi-structured interviews were done and the six stages of a Heuristic Inquiry were used to analyse the …
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Non-invasive Optoacoustic Monitoring of Neonatal Cerebral Venous Oxygen Saturation
… and when severe can lead to neuronal injury and hypoxic-ischemic encephalopathy (HIE) in the newborn. HIE has been reported up to 3/1000 live births with a high mortality of up to 50% and 25% of survivors developing permanent neurological disabilities. Cerebral hypoxia in neonates is a diagnostic …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated …
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The perceived barriers to timely therapeutic hypothermia treatment for neonates diagnosed with hypoxic-ischaemic encephalopathy when born outside the cooling facility within the private healthcare setting
Background Hypoxic-Ischemic Encephalopathy (HIE) is a debilitating neurological injury at birth due to a hypoxic event. The recommended treatment is therapeutic hypothermia (TH) provided at certain neonatal facilities and should commence within the treatment window of 6 hours (1). The outborn …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… in neonates the most common cause of seizures is hypoxic/ischemic encephalopathy (HIE). However, in both adults and neonates, current antiepileptic drugs (AEDs) are ineffective in 30-50% of patients, despite the availability of over 20 FDA approved AEDs with diverse molecular targets. This …
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Classification of Electroencephalogram in Ovine Model of Perinatal Hypoxia by Movement of the Autoregressive Model Parameters
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia occurs when the brain does not receive enough oxygen and blood. Oxygen deprivation can be caused by knotting of the umbilical cord, failure to breathe at birth, as well as a difficult birth. HIE is a dangerous condition that …
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Timing of Therapeutic Hypothermia & Short-Term Infant Outcomes
<p><strong>Background:</strong> Hypoxic-ischemic encephalopathy (HIE) can result in devastating long-term neurological morbidity and/or death. Current evidence recommends initiating Therapeutic Hypothermia (TH), as early as possible, however, research specifically describing TH timing in relation …
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Effects of Elevated Intracranial Pressure on a Cerebral Vein Model
… not result in death, it can result in severe hypoxic brain injury (HBI) and has been shown to increase the likelihood of an eventual fatality in the relationship eightfold [1]. Unfortunately, minimal quantitative biomechanical research has been performed to study strangulation injury, and …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
<p><strong>Introduction:</strong> Neonatal hypoxic-ischemic encephalopathy (HIE) arises from disrupted perinatal cerebral oxygenation and perfusion. It is a leading global cause of infant death and disability which disproportionally affects males. Like adult stroke, HIE initiates a rapid influx of …
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Η προγνωστική σημασία μιας νέας κλινικής βαθμολόγησης της εγκεφαλοπάθειας των νεογνών από περιγεννητική ασφυξία, σε συνδυασμό με τα ευρήματα άλλων εργαστηριακών εξετάσεων
… value of the diagnosis of post asphyxial encephalopathy made on the basis of the clinical symptoms, based on a modification of the description of Fenichel, in combination with imaging and other laboratory examinations. We studied 60 full-term neonates with perinatal asphyxia. Immediately …
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