Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Hypoxic tumor"”.
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The hypoxic tumor microenvironment regulates the LPA signaling axis to promote cancer cell invasion and metastasis
… du LPA joue un rôle important au cours de la tumorigenèse et du développement des métastases, les membres de cette voie étant souvent régulés à la hausse dans les cellules tumorales. La signalisation du LPA a également été impliquée dans la production de structures de dégradation, les …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
<p>Tumor growth often outpaces its vascularization, leading to development of a hypoxic tumor microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… of the p53/Tag complexes and of DNA tumor virus transformation in general. It was generally believed that one of the major functions of Tag was to bind and inactivate the tumor suppressor p53. Our data, instead, support a model in which the Tag/p53 complexes are not inert, but rather …
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The synthesis and characterization of water soluble platinum (II) pophyrins and their potential as radiosensitizers
Cancerous tumors are commonly treated with the use of radiation therapy. Treatment of tumors is difficult, however, due to the fact that tumor cells replicate quickly enough to cut off their supply of oxygen from the vascular system. The lack of oxygen creates regions of hypoxia in the tumor, which …
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Nanoscale Enhancement of Photosensitized Radionuclide Stimulated Therapy
<p>Photodynamic therapy (PDT) provides efficient tumor killing through the generation of reactive oxygen species (ROS) from the optical excitation of a photosensitizer (PS). Furthermore, this mechanism is highly immune stimulating, providing systemic tumor immunity with a reduction in metastasis. …
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Quantitative methods for in vitro and in vivo characterization of cell and tissue metabolism
… oxygen sensor for clinical monitoring of tumor oxygen content in cervical cancer, an in vitro screening platform for monitoring thermal output in a multi-well plate format, and an implantable pH sensor. This thesis presents a silicone-based quantitative oxygen sensor for clinical use in …
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… shape and PEGylation on drug delivery in hypoxic tumor cells</p> <p>3. Develop MSN capable of delivering drug/drug combinations</p> <p>To investigate the effect of surface functionalization of MSN on crystallization, loading, release and activity of mitoxantrone (MTX), we synthesized thiol …
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Mechanistic studies on the role of extracellular vesicles in the tumor microenvironment
… supply, is a common feature of the expanding tumor which alters cell metabolism and consecutively causes lowered intracellular pH. To alleviate hypoxic and acidotic stress, cancer cells respond by promoting blood vessel formation, angiogenesis, and by activating mechanisms for increased …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… By selectively altering the endothelial cells of tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin (CA) family of small molecules has shown great effectiveness as vascular disrupting agents (VDAs). Structure activity relationship (SAR) studies …
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The Role of Neuronal Pentraxin 1 in Promoting Pancreatic Cancer Progression
… in promoting cancer cell proliferating under a hypoxic tumor microenvironment. This proliferation advantage allows cancer cells to survive both in the primary tumor and promotes distal organ metastatic colonization. The final part of this study reveals NPTX1 to be clinically relevant in patient …
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Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… for advanced NSCLC by specifically targeting hypoxic NSCLC tumor environment. We tested this hypothesis in mouse preclinical models of orthotopic, advanced (metastatic) NSCLC. Our results indicate that all treatments (with the exception of MK-2206, which caused lethal glucose intolerance), …
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Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth
… and Provides Novel Targets for Inhibiting Tumor Growth</p> <p>By Geoffrey Grandjean</p> <p>Advisory Professor: Garth Powis, D. Phil</p> <p>Unique to proliferating cancer cells is the observation that their increased need for energy is provided by a high rate of glycolysis followed by lactic …
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Functions of connexin 46 in lens and solid tumors during hypoxia
… Cx46 expression is modulated in breast and bone tumors, and during ischemia. It is hypothesized that Cx46 provides resistance to hypoxia mediated cell death by prolonging survival. In this study, Cx46 expression was detected in human Y79 retinoblastoma cells. Decreasing the expression of Cx46 in …
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Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
… which is commonly associated with cancer and hypoxic cells. The shorter incubation period required for 2-NBDG makes it ideal for clinical use, and 2-NBDG was therefore tested further. </p><p>2-NBDG uptake was used to detect changes in cellular glycolysis after anti-cancer and endocrine …
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Porphyrin chemistry pertaining to the design of anticancer agents
… of selectivity (in term of cell killing) toward tumor cells, especially toward hypoxic tumor cells. Porphyrin drugs used in photodynatnic therapy (PDT) have good selectivity (in term of drug accumulation) toward tumors, but the therapy has a limitation due to poor penetration of light through …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… hyperproliferation results in pro-oxidant tumor cell phenotypes. Thus, tumor cell antioxidant systems are often inherently strained and vulnerable to further oxidative attack. Targeted therapies can be designed to kill tumor cells by pushing them beyond redox thresholds compatible with …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor progression. Most …