Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Hypoxic response pathway"”.
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Chemistry to Biology and Back Again: Small Molecule Regulation of HIF Transcription Factors and the Development of a Platform for the Discovery of New Biocatalyzed Organic Transformations
… is the description of the regulation of the hypoxic response pathway via small molecule inhibitors. The hypoxia response pathway is a way in which cells sense and regulate oxygen levels in cells. Specifically, when oxygen levels in the cells are low, a family of transcription factors known as …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… stabilised, activating a global transcriptional response to ensure cell survival. Interestingly, HIFs can also be activated in aerobic conditions, however the mechanisms of this oxygen-independent regulation are poorly understood. Here, I have explored the role of the vacuolar H+-ATPase …