Global ETD Search
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Showing 1 to 2 of 2 for “"Hypoxic ischemic brain injury (HIBI)"”.
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
Hypoxic ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. Approximately 60 % of preterm babies and 2% of full term infants suffer from asphyxia. Asphyxia related death accounts for approximately 23% of neonatal mortality annually. Many therapeutic interventions …
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Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.
Waixenicin A (WaixA) exhibits potent (615 ± 121 nM) and highly selective inhibition of transient receptor melastatin 7 (TRPM7) over closely related ion channels. Thus, WaixA serves as a potential drug lead for the treatment of hypoxic-ischemic brain injury (HIBI) and a compelling target for …