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Showing 1 to 2 of 2 for “"Hypoxic ischemic brain injury (HIBI)"”.

  1. Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema

    Hypoxic ischemic brain injury (HIBI) is a common cause of neonatal mortality and morbidity. Approximately 60 % of preterm babies and 2% of full term infants suffer from asphyxia. Asphyxia related death accounts for approximately 23% of neonatal mortality annually. Many therapeutic interventions …

    loma-linda Repository record for Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema (opens in a new tab)

  2. Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR.

    Waixenicin A (WaixA) exhibits potent (615 ± 121 nM) and highly selective inhibition of transient receptor melastatin 7 (TRPM7) over closely related ion channels. Thus, WaixA serves as a potential drug lead for the treatment of hypoxic-ischemic brain injury (HIBI) and a compelling target for …

    baylor Repository record for Pharmacophore-directed retrosynthesis (PDR) and Density functional theory studies applied to the potent ion channel inhibitor waixenicin A : synthetic studies toward a more stable salarin C congener, thia-salarin C, through the lens of PDR. (opens in a new tab)