Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Hypoxia-inducible factor 1"”.
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
The development of intratumoral hypoxia is associated with resistance to therapy in many forms of human cancer, and pre-exposure of tumor cells to hypoxia confers multidrug resistance. Research over the last several years has led to considerable advances in the understanding of the cellular …
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Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos
Preconditioning to lowered oxygen levels (hypoxia) may occur when an animal is subjected to non-lethal levels of hypoxia and then returned to normoxic conditions. During a subsequent exposure to hypoxia, the pre-exposed animals may exhibit increased tolerance compared to naive animals. I have …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
… tumor cells, of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor. In the present study I show that curcumin, a turmeric root derivative, and 2-methoxyestradiol (2ME2), a natural metabolite of estradiol, effectively inhibit progestin-induced VEGF secretion from …
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Influence of Preoperative Transcatheter Arterial Chemoembolization on Gene Expression in the HIF-1α Pathway in patients with Hepatocellular Carcinoma
… Since TACE induces hypoxic necrosis in tumors, hypoxia-inducible factor 1α (HIF-1α) could critically affect biology in residual tumors after TACE treatment and subsequent prognosis. However, HIF-1α and its prognostic relevance in TACE have rarely been examined in human …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… aerobic glycolysis pathway which depends on the hypoxia-inducible factor 1α (HIF 1α). I investigated HIF1α expression and responsiveness to 5-FU in two different types of gastric cancer cells (MKN45, SNU216). In addition, we checked the change of the expressions of aerobic …
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
<p>Epidermal growth factor receptor (EGFR) is overexpressed in the majority of head and neck cancers. The anti-EGFR antibody cetuximab has been approved by the FDA for the treatment of head and neck cancers, however, only a small fraction of patients respond to cetuximab treatment. Further …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… which we investigated by probing for hypoxia-inducible factor 1-α (HIF1-α) in the 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-model of colitis in adult rats. By Day 2 of TNBS-induced colitis, HIF1-α presence in the nuclei of myenteric neurons had significantly increased, indicating …
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Using affinity purification -- mass spectrometry to identify aryl hydrocarbon receptor nuclear translocator interacting proteins
… show that the ARNT-AhR heterodimer needs protein factors to bind to DRE, and most of these protein factors are still unknown. ARNT also heterodimerizes with hypoxia inducible factor 1 a (HIF-1 a) which mediates the cellular responses to hypoxia. The purpose of this research is to use a combination …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
… events were detected, such as an increase of hypoxia inducible factor 1 (HIF-1) mRNA levels, a decrease of human mu opioid receptor (hMOR) message, and no change of human delta opioid receptor (hDOR) receptor message. Western blot analysis showed the Janus kinase (JAK)/ Signal Transducers and …
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Invadopodia Formation in Breast Cancer
… can be driven by signalling via growth factors such as hepatocyte growth factor (HGF) and by the surrounding microenvironment. During initial tumour expansion intratumoral hypoxia can develop due to inadequate vasculature supply. To resist the negative effect of hypoxia, cells increase …
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The Anti-Inflammatory Effects of Low Concentrations of Carbon Monoxide in Human Airway Smooth Muscle Cells
… granulocyte macrophage colony stimulating factor (GM-CSF). However, the mechanism related to the decrease in GM-CSF release requires further exploration. Evidence demonstrates similarities in effect on oxidative stress and metabolism and subsequent effects on inflammation between hypoxic …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… Using C57BL/6J mice exposed to normoxia, hypoxia or hyperoxia, we studied the systemic physiological and brain microvascular adaptive changes in response to fluctuations in atmospheric oxygen level. In the first part of this project, we determined the relative time course of capillary …
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Discovery of small-molecule natural products that target cellular bioenergetics
… favor in antitumor drug discovery programs. Hypoxia (< 5% oxygen) is a comfeature of solid tumors and hypoxia-inducible factor-1 (HIF-1) represents an important antitumor target. Bioenergetic homeostasis is typically altered in tumor cells and HIF-1 plays an important role to produce a …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
… ligand independent activation of the receptor. Hypoxia and hypoxia inducible factor-1? (HIF-1) expression has been correlated to loss of ER in breast tumors. Cyclin D1, initially described as a cell cycle regulator, might also function as a cofactor to ER inducing ligand independent activation …
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Chronic Hypoxia Induces Epigenetic Modifications in the Fetal Rat Heart
… of stress during gestation as a risk factor for heart diseases has expanded. We now know that events in utero can significantly alter gene expression patterns in heart tissue leading to increase susceptibility to ischemia reperfusion injury in adulthood. The focus of this project was …
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Defining the Role of Secondary DNA Structures and Transcription Factors on the Transcriptional Control of the HIF-1alpha and VEGF Promoters
… in tumors by the constant expression of the hypoxia inducible factor 1 alpha (HIF-1α) and human vascular endothelial growth factor (VEGF). In fact, tumor recurrence, aggressive metastatic legions and patient mortality rates are known to be positively correlated with overexpression of these …
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A three-dimensional in vitro tumor model representative of the in vivo tumor microenvironment
… breast cancer cells were shown to experience hypoxia and undergo necrosis in response to limitations in oxygen diffusion and competition for nutrients. Upregulation of hypoxia-inducible factor-1" resulted in a significant increase in vascular endothelial growth factor gene expression. To …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… matched by new vessel formation, leading to AT hypoxia. As a result, hypoxia inducible factor-1⍺ (HIF-1⍺) accumulates in adipocytes inducing a transcriptional program that upregulates profibrotic genes and biosynthetic enzymes such as lysyl oxidase (LOX) synthesis. This excess synthesis and …
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