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Showing 1 to 13 of 13 for “"Hypoxia-Ischemia, Brain"”.
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
… with HI before exposing mice to traumatic brain injury (TBI). Compared to animals only injured with TBI, mice with both injuries displayed decreased progenitor proliferation suggesting an impaired capacity for repair. We have therefore identified a novel and clinically relevant role for …
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Gene Delivery of Adenoviral-TMBIM6 Vector Protects the Neonatal Brain after Hypoxic-Ischemic Injury
<p>Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive …
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Effect of Procedural Pain on Purines, MDA and Allantoin in Premature Infants
… the relationship between procedural pain and hypoxia on ATP utilization and oxidative stress. Lastly, it is important to stratify subjects based on health status or morbidity, due to the significant effects of respiratory diseases on ATP use and oxidative stress.
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… detected in the central nervous system, reduce brain infarction volumes, and improve neurological behavior tests 24 hours after HIE. Administration of G-CSF was able to play a pivotal role in attenuating neuroinflammation and BBB disruption 48 hours following HIE. Similarly, OPN was able to …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… one of the most common stresses in utero is hypoxia. The goal of this project is to test the hypothesis that fetal hypoxia causes reprogramming of MMPs and TIMPs expression patterns and activities leading to aberrant brain and heart development in the fetuses and neonates. In the first part …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
<p>Hypoxia-ischemia (HI) occurs in 1-6/1000 live full-term births (Shankaran, 2009). Of those affected, 15-20% will die in the postnatal period, and 25% of survivors will be left with long-term neurological disabilities (Gunn, 2000; Vannucci, 1997; Fatemi, 2009). It has become increasingly clear …
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Acclimatization to High-Altitude, Long-Term Hypoxia Alters BK Channel Structure and Function
<p>We examined the major possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… neurobehavioral disorders among others. Maternal hypoxia is one of the most common intrauterine growth restricted environment during pregnancy. Perinatal hypoxic-ischemic encephalopathy is an important cause of brain injury in the newborn due to a systematic asphyxia. Our study aims to test the …
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The Role of VEGF and Smooth Muscle Phenotype in Hypoxic Remodeling of Ovine Carotid and Cerebral Arteries
… and local factors to maintain homeostasis. Hypoxia stimulates capillary angiogenesis to effectively match metabolic demand with perfusion. With chronic hypoxia, vascular remodeling of even large vessels can occur. This predisposes to pathologic states as seen with atherosclerosis, hypoxic …
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VEGF and Sympathetic Perivascular Nerves Contribute to Hypoxic Remodeling of Ovine Cranial Arteries
Chronic hypoxia complicates many pregnancies and can result in postnatal pathologies that include compromised fetal cardiovascular structure and function. Mechanisms involved remain unclear. Because hypoxia increases production of VEGF, known to modulate smooth muscle (SM) phenotype, this thesis …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
<p>Perinatal hypoxic-ischemic (HI) brain injury is a major cause of acute morbidity and chronic nemological mortality in infants and children, with a reported incidence of 2- 9 per 1000 births. The pathophyiological mechanisms leading to immature brain damage after HI are complex and relate to the …
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Neuropsychological Outcome following Perinatal HIE: Utility of MR Spectroscopy
<p>Outcome following hypoxic-ischemic encephalopathy (HIE), a neurodegenerative process caused by prolonged asphyxiation during birth, can vary between minimal impairment and cerebral palsy, mental retardation, or death (30%) (McCulloch, Taylor, & Whyte, 1991). Prognosis after HIE is often …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… (ACTH), and corticosterone is increased after a brain insult. These hormones are the effectors secreted respectively by the pituitary and adrenal glands. It has been shown that the down-regulation of corticosterone levels can improve detrimental outcomes associated with ischemic brain injuries. …