Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Hypoxia-Inducible Factors (HIFs)"”.
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… Most notably, my study has identified several factors such as the peroxisome proliferator-activator receptor gamma (PPARgamma), hypoxia-inducible factors (HIFs), and interleukin-6 (IL-6) as critical regulators of ovulation. These factors function as the downstream mediators of the PR signal to …
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Chemistry to Biology and Back Again: Small Molecule Regulation of HIF Transcription Factors and the Development of a Platform for the Discovery of New Biocatalyzed Organic Transformations
… pathway via small molecule inhibitors. The hypoxia response pathway is a way in which cells sense and regulate oxygen levels in cells. Specifically, when oxygen levels in the cells are low, a family of transcription factors known as hypoxia inducible factors (HIFs) is up regulated. …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
… and cellular assays, I determine the role of hypoxia in the regulation of cholesterol synthesis, and also characterise the ubiquitination machinery for an ERAD pathway involving the degradation of misfolded cytosolic proteins. Under low sterol conditions, I show that low oxygen availability …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. Recombinant human EPO (rhEPO) is also used in treatment of cancer patients with anemia but some …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… ligase complex responsible for targeting Hypoxia Inducible Factors (HIFs) for proteasomal degradation. Accumulation of the HIF-2α isoform, in particular, drives renal tumourigenesis. *VHL* loss occurs at an early stage of ccRCC development, often several years before the clinical …
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… measured the expression of a panel of angiogenic factors secreted by GSCs. In comparison with matched non-GSC populations, GSCs consistently secreted markedly elevated levels of vascular endothelial growth factor (VEGF), which were further induced by hypoxia. In an in vitro model of angiogenesis, …
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Hypoxia signalling regulates human lung epithelial cell fates
… tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of …
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Metabolic control of immune cell fate by hypoxia-inducible factors
… cellular metabolism and gene transcription. The hypoxia-inducible factors (HIFs), which are regulated by oxygen-sensing hydroxylases, have a central role in maintaining oxygen homeostasis in cells throughout the body. This work explores the role of HIF signalling in T cells and how modulation of …
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Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… therapy. Recent evidence indicates that hypoxia induces cancer stem cell (CSC) phenotypes via epithelial-to-mesenchymal transition (EMT) that promote therapeutic resistance in solid tumours. Given that GBMs are extensively hypooxygenated heterogenous tumours, understanding the molecular …
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Role of Fam60a in the Regulation of HIF-2α and Determination of Stem Cell Fate
Hypoxia (low tissue oxygenation) is an important signalling cue for many cell types. The study of its effects has direct relevance to surgery since hypoxic gradients are generated with every cut. On a cellular level, changes in molecular oxygen are sensed by the Hypoxia-Inducible Factors (HIFs). …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… and tumour relapse. My study demonstrates that hypoxia is involved in the development and maintenance of these CSCs traits in TNBC, as cells grown in hypoxia are significantly resistant to several first line anti-BC drugs. Hypoxia-induced activation of nuclear factor kappa B (NFB) and hypoxia …
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HIF and NF-ĸB Crosstalk: The Role of HIF-1β as an Inducer of the Inflammatory Response
Inflammation and hypoxia, or decreased oxygen availability, are two relevant conditions involved in a large variety of physiological and pathological processes, such as immune diseases and cancer. At molecular level, these stress responses are strictly orchestrated by evolutionary conserved …
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Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH
Factor Inhibiting the Hypoxia Inducible Factor (FIH) is an oxygen-dependent asparaginyl hydroxylase that plays a role in the cellular response to changes in oxygen concentrations. It was first found to catalyse the post translational hydroxylation of a family of transcription factors known as …