Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"Hypoxia-Inducible Factor"”.
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Role of Hypoxia-inducible Factor in Kidney Cancer
… mammalian cells, reduced oxygen availability, or hypoxia, triggers a myriad of alterations within molecular pathways aimed at ensuring sustained viability and functionality of vital organs. The master regulator of the hypoxic response is the heterodimeric HIF transcription factor, composed of an …
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Studies into the receptor-mediated induction of hypoxia inducible factor 1α.
The transcription factor Hypoxia Inducible Factor (HIF) is pivotal to the cellular response upon exposure to low oxygen stress (hypoxia). Post-translational modification of the HIF a-subunit (HIFa) by hydroxylase enzymes has recently been identified as the key 'oxygen sensing' mechanism within the …
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Dual Mechanisms Regulating Alpha Subunit-Specific Activity in Hypoxia-Inducible Factor Signaling
… availability. Throughout the animal kingdom, hypoxia-inducible factor has emerged as a master regulator of this response. These bHLH transcription factors enhance transcription of a variety of genes that work to maintain oxygen homeostasis and allow adaptation to decreased oxygen availability. …
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Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α
… contain regions of reduced oxygen availability. Hypoxia has been identified as a major negative prognostic factor for tumor progression and resistance to anti-cancer therapies. Hypoxia promotes cell proliferation, immortalization, genetic instability, and induces cells to switch their methods of …
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
The development of intratumoral hypoxia is associated with resistance to therapy in many forms of human cancer, and pre-exposure of tumor cells to hypoxia confers multidrug resistance. Research over the last several years has led to considerable advances in the understanding of the cellular …
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Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells.
… concentration would result in a state of pseudo hypoxia, and potentially the expression of hypoxia-inducible factor-alpha (HIF-1alpha). In an animal model of diabetes, HIF-1alpha protein expression was seen to increase in the vasculature surrounding the sciatic nerve at ten- and twenty-four weeks …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor patient outcomes, their functions within the PDAC tumor microenvironment (TME) remain unknown. This dissertation examines the …
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Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth
… Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides Novel Targets for Inhibiting Tumor Growth</p> <p>By Geoffrey Grandjean</p> <p>Advisory Professor: Garth Powis, D. Phil</p> <p>Unique to proliferating cancer cells is the observation that their …
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Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos
Preconditioning to lowered oxygen levels (hypoxia) may occur when an animal is subjected to non-lethal levels of hypoxia and then returned to normoxic conditions. During a subsequent exposure to hypoxia, the pre-exposed animals may exhibit increased tolerance compared to naive animals. I have …
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… tumour growth in vivo and to study the role of hypoxia inducible factor driven hypoxia signalling in OSMR overexpressing SCC cells and their tumour microenvironment. OSMR overexpression was found to sensitise tumour cells to induce Hypoxia inducible factor 1a and 2a (HIF1a, HIF2a) signalling in …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within …
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the …
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DNMT3a Epigenetic Program Regulates the HIF-2alpha Oxygen Sensing Machinery
… the DNA methylation program in the regulation of hypoxia-inducible factor (HIF) oxygen-sensing machinery. We show that DNA methyltransferase 3a (DNMT3a) methylates and silences the HIF-2alpha gene (EPAS1) in normal cells. Epigenetic silencing of EPAS1 prevents activation of the HIF-2alpha gene …
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
… on AAMs, and inhibition or genetic silencing of hypoxia inducible factor 1a (HIF1A) as a means to attenuate pro-fibrotic mediator production and pulmonary fibrosis in bone marrow derived macrophages (BMDMs) and in vivo models of bleomycin-induced pulmonary fibrosis. These players will be valuable …
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Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2
… initiation scaffold eukaryotic initiation factors 4GI and II (eIF4GI/II), which recruit mRNAs to ribosomes in mammals. Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to ribosomes. Despite extensive work describing eIF4GI, an understanding of …
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