Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 28 for “"Hypoxia Inducible Factors"”.
-
Characterising mechanisms of regulation of hypoxia-inducible factors.
… Mammalian cells adapt to low oxygen stress (hypoxia) through a transcriptional response pathway mediated by the Hypoxia-inducible factor protein, HIF. HIF is a heterodimer consisting of one of three alpha subunits (HIF-1a, HIF-2a or HIF-3a) and a beta subunit called Amt. The activation of HIF …
-
Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… contain regions of oxygen deficiency ? hypoxia ? caused by a high rate of cellular proliferation and abnormal intratumoral blood supply. In this hypoxic microenvironment cancer cells undergo genetic and molecular changes, allowing continued survival and proliferation. Tumor hypoxia is …
-
Metabolic control of immune cell fate by hypoxia-inducible factors
… cellular metabolism and gene transcription. The hypoxia-inducible factors (HIFs), which are regulated by oxygen-sensing hydroxylases, have a central role in maintaining oxygen homeostasis in cells throughout the body. This work explores the role of HIF signalling in T cells and how modulation of …
-
Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out …
-
Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. Recombinant human EPO (rhEPO) is also used in treatment of cancer patients with anemia but some …
-
HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
… induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic …
-
Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… Most notably, my study has identified several factors such as the peroxisome proliferator-activator receptor gamma (PPARgamma), hypoxia-inducible factors (HIFs), and interleukin-6 (IL-6) as critical regulators of ovulation. These factors function as the downstream mediators of the PR signal to …
-
Role of PBRM1 in regulation of the HIF pathway
Hypoxia Inducible Factors are a family of transcription factors mediating the transcriptional response to hypoxia. They are heterodimers consisting of an oxygen-regulated α subunit and an oxygen-independent β subunit. In normoxia HIFα is quickly degraded by a VHL-mediated mechanism whereas hypoxia …
-
Chemistry to Biology and Back Again: Small Molecule Regulation of HIF Transcription Factors and the Development of a Platform for the Discovery of New Biocatalyzed Organic Transformations
… pathway via small molecule inhibitors. The hypoxia response pathway is a way in which cells sense and regulate oxygen levels in cells. Specifically, when oxygen levels in the cells are low, a family of transcription factors known as hypoxia inducible factors (HIFs) is up regulated. …
-
Regulation of Protein Degradation at the Endoplasmic Reticulum
… and cellular assays, I determine the role of hypoxia in the regulation of cholesterol synthesis, and also characterise the ubiquitination machinery for an ERAD pathway involving the degradation of misfolded cytosolic proteins. Under low sterol conditions, I show that low oxygen availability …
-
THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… consisting of adjacent cells and factors produced by these. An important feature of the HSC niche seems to be a relatively low level of oxygen: hypoxia. Hypoxia leads to activation of Hypoxia-Inducible Factors (HIF). We have investigated the role of hypoxia and HIFs in HSC biology. …
-
Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
… ligase complex responsible for targeting Hypoxia Inducible Factors (HIFs) for proteasomal degradation. Accumulation of the HIF-2α isoform, in particular, drives renal tumourigenesis. *VHL* loss occurs at an early stage of ccRCC development, often several years before the clinical …
-
The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor patient outcomes, their functions within the PDAC tumor microenvironment (TME) remain unknown. This dissertation examines the …
-
Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… measured the expression of a panel of angiogenic factors secreted by GSCs. In comparison with matched non-GSC populations, GSCs consistently secreted markedly elevated levels of vascular endothelial growth factor (VEGF), which were further induced by hypoxia. In an in vitro model of angiogenesis, …
-
Hypoxia signalling regulates human lung epithelial cell fates
… tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of …
-
Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme
… therapy. Recent evidence indicates that hypoxia induces cancer stem cell (CSC) phenotypes via epithelial-to-mesenchymal transition (EMT) that promote therapeutic resistance in solid tumours. Given that GBMs are extensively hypooxygenated heterogenous tumours, understanding the molecular …
-
Role of Fam60a in the Regulation of HIF-2α and Determination of Stem Cell Fate
Hypoxia (low tissue oxygenation) is an important signalling cue for many cell types. The study of its effects has direct relevance to surgery since hypoxic gradients are generated with every cut. On a cellular level, changes in molecular oxygen are sensed by the Hypoxia-Inducible Factors (HIFs). …
-
Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… and tumour relapse. My study demonstrates that hypoxia is involved in the development and maintenance of these CSCs traits in TNBC, as cells grown in hypoxia are significantly resistant to several first line anti-BC drugs. Hypoxia-induced activation of nuclear factor kappa B (NFB) and hypoxia …
-
Hypoxia-induced phenotypic modulation of human neuroblastoma cells
… outcome. In earlier studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray analysis to investigate the hypoxic effects, in neuroblastoma cells, on the expression of a larger set …
-
HIF and NF-ĸB Crosstalk: The Role of HIF-1β as an Inducer of the Inflammatory Response
Inflammation and hypoxia, or decreased oxygen availability, are two relevant conditions involved in a large variety of physiological and pathological processes, such as immune diseases and cancer. At molecular level, these stress responses are strictly orchestrated by evolutionary conserved …
Page 1 of 2