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Showing 1 to 20 of 24 for “"Hypoxia Inducible Factor 1α"”.

  1. Studies into the receptor-mediated induction of hypoxia inducible factor 1α.

    Bilton, Rebecca2003

    The transcription factor Hypoxia Inducible Factor (HIF) is pivotal to the cellular response upon exposure to low oxygen stress (hypoxia). Post-translational modification of the HIF a-subunit (HIFa) by hydroxylase enzymes has recently been identified as the key 'oxygen sensing' mechanism within the …

    adelaide Repository record

  2. Inhibition of Breast Cancer Angiogenesis and Metastasis ay Targeting Hypoxia-Inducible Factor-1α

    Madu, Chikezie O.2016

    … contain regions of reduced oxygen availability. Hypoxia has been identified as a major negative prognostic factor for tumor progression and resistance to anti-cancer therapies. Hypoxia promotes cell proliferation, immortalization, genetic instability, and induces cells to switch their methods of …

    tenn-hsc Repository record

  3. Regulation of HIF-1α during Hypoxia by DAP5-Induced Translation of PHD2

    Bryant, Jeffrey2018

    … initiation scaffold eukaryotic initiation factors 4GI and II (eIF4GI/II), which recruit mRNAs to ribosomes in mammals. Unlike eIF4GI/II, DAP5 binds eIF2β, a subunit of the eIF2 complex that delivers methionyl-tRNA to ribosomes. Despite extensive work describing eIF4GI, an understanding of …

    duke Repository record

  4. Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells

    XUAN, YI2014

    … I investigated whether gastric cancer with hypoxia-induced resistance to 5-fluorouracil (5-FU) could be re-sensitized following treatment with low-dose dichloroacetate (DCA), an inhibitor of the glycolytic pathway. The expression profile of hypoxia-inducible factor-1α (HIF-1α) and pyruvate …

    ajou Repository record

  5. HIF-1alpha role in oxygen-dependent radio- and chemosensitivity

    Gebolys, KingaUniversity College Cork2014

    Poor oxygenation (hypoxia) is a common characteristic of human solid tumours, and is associated with cell survival, metastasis and resistance to radio- and chemotherapies. Hypoxia-induced stabilisation of hypoxia-inducible factor-1α (HIF-1α) leads to changes in expression of various genes …

    cork Repository record

  6. Μελέτη των μοριακών μηχανισμών ανάπτυξης του οφθαλμικού πτερυγίου στον άνθρωπο : ο ρόλος του μεταγραφικού παράγοντα HIF-1α, της πρωτεΐνης pVHL και των πρωτεΐνών θερμικού σοκ

    Παγουλάτος, Διονύσιος2015

    … αύξηση της έκφρασης του μεταγραφικού παράγοντα Hypoxia-inducible factor-1α (HIF-1α), ο οποίος είναι γνωστό ότι παίζει κρίσιμο ρόλο στη ρύθμιση του μεταβολισμού των κυττάρων καθώς και στην επιβίωση των αρχέγονων κυττάρων (stem cells). Σε φυσιολογικές συνθήκες οξυγόνου η πρωτεΐνη von Hippel Lindau …

    patras-thes Repository record

  7. Effects of Hyperoxia on Thermal Tolerance and Indicators of Hypoxic Stress in Antarctic Fishes That Differ in Expression of Oxygen-Binding Proteins

    Devor, Devin PatrickOhio University2013

    … rises, correlates of oxygen limitation (hypoxia inducible factor-1α and lactate) would increase to a greater extent in icefishes compared to red-blooded fishes and that this increase would be minimized under hyperoxic conditions. I sampled <i>Chaenocephalus aceratus</i> (Hb-) and …

    ohiolink Repository record

  8. Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling

    Isaza-Correa, Johana M.National University of Ireland Maynooth2018

    … of TLR signalling pathways in the activation of hypoxia-inducible factor 1α (HIF-1α), a critical target of the ubiquitin/proteasome system. Interestingly, these studies revealed that some of the TLRs promote a faster migration form of HIF-1α of approximately 40kDa. The upregulation of the latter …

    maynooth Repository record

  9. Environmental signals that control T lymphocytes in the gastrointestinal tract

    Ramsay, GeorgeUniversity of Dundee2015

    … the Aryl Hydrocarbon Receptor (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and HIF-1α is a sensor of low oxygen tension. Deletion of the AHR …

    dundee Repository record

  10. Resveratrol slows cell growth by targeting the Warburg effect and stimulating mitochondria metabolism

    Fonseca, JoaoBrock University2019

    … by growing cells in galactose or stabilizing hypoxia inducible factor-1α (HIF-1α) expression, RES effects on growth and metabolism were attenuated or even abolished. Furthermore, consistent with RES ability to reduce HIF-1α levels, I observed that RES’s cell growth inhibitory effects were …

    brock Repository record

  11. Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells

    Rolls, Barbara AnnThe University of Texas Medical Branch at Galveston2021

    … to cigarette smoke, which suggested that the hypoxia inducible factor-1α (HIF-1α) may be involved in mediating the resulting inflammation. This also suggested that the effects of cigarette smoke and sulfur dioxide, two air pollutants commonly present in the industrial areas south of Houston, …

    utmb Repository record

  12. Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells

    Rolls, Barbara AnnThe University of Texas Medical Branch at Galveston2021

    … to cigarette smoke, which suggested that the hypoxia inducible factor-1α (HIF-1α) may be involved in mediating the resulting inflammation. This also suggested that the effects of cigarette smoke and sulfur dioxide, two air pollutants commonly present in the industrial areas south of Houston, …

    utmb Repository record

  13. Microencapsulated human islets as a therapy for type 1 diabetes

    Vaithilingam, VijayaganapathyUNSW, Sydney2010

    … Many non-immunological and immunological factors such as limited islet availability, reduced immunoprotection, effect of the encapsulation process, hypoxia and inflammatory response hinder the successful application of this promising technology. In this study, strategies were designed to …

    unsw Repository record

  14. Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries

    Silpanisong, Jinjutha

    <p>Intrauterine hypoxia resulting from decreased maternal oxygen uptake, insufficient oxygen carrying capacity, or compromised oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases …

    loma-linda Repository record

  15. HIF, HAPE, and Hilltop rats: a paradox unfolding

    Engebretsen, Barbara J., author, Tucker, Alan, advisor, Miller, C. W., committee member, Gotshall, Robert, committee member, Cordain, Loren, committee memberColorado State University. Libraries2003

    … edema (HAPE) than control Madison rats. Hypoxia Inducible Factor-1α (HIF-1α) is exquisitely coupled to cellular hypoxia, enhancing expression of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (NOS II), a potent generator of nitric …

    colostate Repository record

  16. Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer

    Riis, SarahUniversity College Cork2020

    The evolutionarily conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells …

    cork Repository record

  17. Ritonavir - A Novel Multidrug Resistance Modulator in Cancer Chemotherapy and Ocular Neovascular Diseases

    Vadlapatla, Ramya KrishnaUniversity of Missouri--Kansas City2014

    … drug concentration, is one of the predominant factors limiting effective cancer chemotherapy. Several possible mechanisms and molecular alterations have been implicated in the development of MDR, including activation of efflux transporters and metabolizing enzymes in response to therapeutic …

    umkc Repository record

  18. Normal Glycolytic Enzyme Activity Is Critical For Hypoxia Inducible Factor-1A Activity and Provides Novel Targets For Inhibiting Tumor Growth

    Grandjean, Geoffrey, PhD2015

    … Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1α Activity and Provides Novel Targets for Inhibiting Tumor Growth</p> <p>By Geoffrey Grandjean</p> <p>Advisory Professor: Garth Powis, D. Phil</p> <p>Unique to proliferating cancer cells is the observation that their …

    uthsc Repository record

  19. Dissecting adult epithelial cell plasticity using a model of oesophageal-to-skin lineage conversion

    Jimenez Gomez, PaulaUniversity of Cambridge2022

    … and loss of function experiments targeting the hypoxia-inducible factor-1α (HIF1a) and its downstream target SRY-box transcription factor 9 (SOX9). These results unveiled that the HIF1a-SOX9 axis poses a barrier to oesophageal-to-skin lineage conversion. In turn, when this barrier is lifted …

    cambridge Repository record

  20. Understanding Radiation Resistance in Head and Neck Tumor Xenografts Using Diffuse Reflectance and Raman Spectroscopy

    Dadgar, Sina2024

    … biomarkers of treatment response. Because tumor hypoxia has been linked to poor treatment outcome, we employed diffuse reflectance spectroscopy to measure vascular oxygen saturation. In chapter 2, we first investigated the sensitivity of diffuse reflectance spectroscopy to tumor hypoxia and …

    arkansas Repository record

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