Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 899 for “"Hypoxia"”.
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
… name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out to explore the impact of hypoxia on mammary epithelial differentiation and what consequences the hypoxic response might have on breast cancer …
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Preeclampsia Link to Gestational Hypoxia
… uteroplacental perfusion, triggering placental hypoxia and oxidative stress. In turn, placental dysfunction is thought to be a common denominator between upstream adverse effects on the mother and downstream adverse effects on the fetus. Maternal adverse effects include the angiogenic imbalance …
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
The development of intratumoral hypoxia is associated with resistance to therapy in many forms of human cancer, and pre-exposure of tumor cells to hypoxia confers multidrug resistance. Research over the last several years has led to considerable advances in the understanding of the cellular …
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Hypoxia regulated pathways in urological malignancies
… of this are yet to be fully elucidated. Hypoxia inducible factor isoforms, HIF-1 and<br/>HIF-2, are constitutively expressed in many clear-cell RCCs due to loss of pVHL tumour<br/>suppressor function within the tumour. In vitro, HIF-1 and HIF-2 regulate a differential set of<br/>target …
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Maternal and placental adaptations to hypoxia
… responses, a physiological stressor such as hypoxia was used to exaggerate pregnancy-induced vascular remodeling, which induced maternal adaptive responses to protect the fetus. In this dissertation, we describe studies designed to evaluate cellular and molecular mechanisms underlying …
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Electrochemical Focal Hypoxia for Cell Models
… decades, there has been increasing attention to hypoxia’s (low oxygen) contribution to poor prognosis and ineffective treatments. Despite existing physiologically, hypoxia is a pathological accompaniment in a myriad of diseases, including tumour, stroke, dementia and cardiovascular diseases, that …
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Modulation of neutrophil degranulation by hypoxia
… The key finding reported in this thesis is that hypoxia substantially increases the release of all neutrophil granule subsets, as measured by the release of (active) hallmark proteins (elastase, myeloperoxidase, lactoferrin and matrix metalloproteinase-9). In consequence, supernatants from …
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Hypoxia-induced responses of porcine pulmonary veins.
The pulmonary vein (PV) constricts to hypoxia however little is known about the underlying mechanisms. Hypoxic PV constriction is proposed to recruit upstream capillary beds and optimise gas exchange in healthy humans and may play a role in high altitude pulmonary oedema. The PV is also intrinsic …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… mammalian cells, reduced oxygen availability, or hypoxia, triggers a myriad of alterations within molecular pathways aimed at ensuring sustained viability and functionality of vital organs. The master regulator of the hypoxic response is the heterodimeric HIF transcription factor, composed of an …
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The regulation of human iron metabolism in hypoxia
… inspired oxygen (FIO2) = 0.2093) and normobaric hypoxia (i.e. 3,000 m simulated altitude; FIO2 = 0.1450). These results suggest exercise performed in acute hypoxia does not alter the post-exercise hepcidin response, relative to exercise in normoxia, possibly owing to the short duration of the …
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Effects of hypoxia on exercise induced muscle damage
The present study investigated the hypothesis that maximal voluntary contractions (MVC) peak torque, VJ, muscle tenderness, and plasma creatine activity would be significantly less for the condition that subjects were exposed to hypoxic (H) condition for 4 hours after eccentric exercise compared …
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Chronic hypobaric hypoxia: physiological implications for exercise performance
… adaptation.In contrast, chronic hypobaric hypoxia (~Pi02 of 115 mmHg to 125 mmHg) was associated with adverse changes in immune function. A significant decrease in resting plasma glutamine concentration (P < 0.001 vs pre-altitude mean) may have been implicated in an increased frequency of …
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Hypoxia-induced phenotypic modulation of human neuroblastoma cells
… outcome. In earlier studies we have found that hypoxia induces dedifferentiation of neuroblastoma cells, which implies that hypoxia evokes a more aggressive phenotype. Here we employ microarray analysis to investigate the hypoxic effects, in neuroblastoma cells, on the expression of a larger set …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
<p>Hypoxia-ischemia (HI) occurs in 1-6/1000 live full-term births (Shankaran, 2009). Of those affected, 15-20% will die in the postnatal period, and 25% of survivors will be left with long-term neurological disabilities (Gunn, 2000; Vannucci, 1997; Fatemi, 2009). It has become increasingly clear …
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64Cu-bis(thiosemicarbazone) complexes for delineating myocardial hypoxia
… remodelling are often characterised by tissue hypoxia. They benefit from the earliest possible diagnosis and treatment. Positron Emission Tomography (PET) is a highly sensitive technique capable of non-invasively imaging the biochemistry of the body, with the capacity to track biochemical …
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Characterising mechanisms of regulation of hypoxia-inducible factors.
… Mammalian cells adapt to low oxygen stress (hypoxia) through a transcriptional response pathway mediated by the Hypoxia-inducible factor protein, HIF. HIF is a heterodimer consisting of one of three alpha subunits (HIF-1a, HIF-2a or HIF-3a) and a beta subunit called Amt. The activation of HIF …
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The responses of ventrolateral medullary neurons to hypoxia
… (VLM) neurons during brief exposures of hypoxia. Extracellular recordings of VLM neurons in anesthetized rats demonstrated a large proportion (64%) which were excited during brief hypoxia (10% O$\sb2$, 60 sec). A similar percentage of VLM neurons (65%) were similarly stimulated in …
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Hypoxia signalling regulates human lung epithelial cell fates
… tension (< 5% O2) during the first trimester. Hypoxia substantially impacts mammalian development and tissue homeostasis. However, it remains unclear whether and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of …
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