Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Hypothalamic–pituitary–gonadal axis"”.
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Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis
Background: Hypothalamic kisspeptin and neurokinin B (NKB) are central regulators of GnRH and thus gonadotropin (LH and FSH) secretion. Men and women with loss-of-function mutations in NKB-kisspeptin pathway show hypogonadotropic pubertal delay with reduced GnRH/LH pulsatility. Studies in patients …
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In vitro model of the fathead minnow hypothalamic-pituitary-gonadal axis for toxicological evaluation
… they impact reproduction by interfering with the hypothalamic-pituitary-gonadal axis (HPG axis). This changes fecundity at the organismal and population level, potentially leading to population crashes. Development of chemicals for agricultural, industrial, and personal use has led to over 80,000 …
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Reproductive health effects due to pesticide exposure amongst boys in the rural Western Cape, South Africa
… endocrine system, through their actions on the hypothalamic-pituitary-gonadal axis. Reported male reproductive abnormalities are reproductive organ defects, cancers and declining fertility. Cryptorchidism, hypospadias, testicular cancer and poor sperm quality (testicular dysgenesis syndrome) …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… (GnRH) receptors on the surface of anterior pituitary gonadotrope cells is a key signaling event for the hypothalamic-pituitary-gonadal axis. One important downstream component of GnRH receptor signaling is activation of the mitogen-activated protein kinase ERK (extracellular signal-regulated …
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Gonadotropin releasing hormone in agnathans
… among extant vertebrates. The regulatory hypothalamic neurohormone, gonadotropin-releasing hormone (GnRH), regulates reproduction in all vertebrates through the hypothalamic-pituitary-gonadal axis. Most vertebrates have at least two forms of GnRH in the brain. In hagfish the primary amino …
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Gonadal histology and reproductive steroidogenesis of anurans exposed to potential endocrine disrupting contaminants
… may be due at least in part to impacts on the hypothalamic-pituitary-gonadal axis. The present studies investigate the effects of exposure to environmental contaminants including DDT and atrazine on the development, gonadal histology and reproductive steroidogenesis of larval anurans.</p><p>As …
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Interactions of GPR54 and GPR147 receptors with RF-amide ligands
… GPR54 play a critical role in the control of the hypothalamic-pituitary-gonadal axis by regulating gonadotropin-releasing hormone secretion. Despite the physiological importance of GPR54/kisspeptin signalling, the GRP54 residues important for receptor activation and signalling have not been …
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The Role of the Nhlh2 Protein in Regulating Male Fertility and Sexual Development
… (NHLH2) transcription factor is expressed in the hypothalamic-pituitary-gonadal axis (HPG), which controls the development of primary and secondary sex characteristics. Signaling from the pituitary reaches the Leydig cells of the testis, which in response produce testosterone, leading to proper …
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In-vivo analysis of hypothalamic kisspeptin neuron activity patterns
Mammalian reproduction is regulated by the brain, pituitary gland, and gonads. In the brain, gonadotropin-releasing hormone (GnRH) is released to stimulate the pituitary gland. In females, two distinct modes of GnRH secretion are controlled by two populations of hypothalamic kisspeptin neurons …
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Fetal programming in cattle: the effects of varying maternal protein intake in adolescent beef heifers on fetal and postnatal growth and development of the calf
… diet may have altered the development of the hypothalamic–pituitary-gonadal axis and the corresponding receptivity to circulating hormones. These male offspring underwent a 70-day residual feed intake feedlot test commencing at 528 days of age. Offspring from heifers that had a change in diet …
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Prenatal exposure to phthalates accelerates reproductive aging in multiple generations of female mice
… pool, dysregulation of hormones involved in the hypothalamic-pituitary-gonadal (HPG) axis including sex steroids, gonadotropin, and peptide hormones, irregular estrous/menstrual cycles, and together this can lead to infertility. Moreover, the ovary has been shown to exhibit direct signs of aging, …
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Appearance Over Function - The Impact of Long-Term Oral Contraceptive Use on Brain Development, Breast Tissue Composition, and Future Lactation Outcomes
<p>This integrative review examines the long-term effects of combined oral contraceptive (COC) use beginning in puberty on brain development, breast tissue composition, and future breastfeeding outcomes. Puberty is a critical developmental stage during which hormonal changes significantly impact …