Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Hypogonadism"”.
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The long-term effects of testosterone replacement therapy in aging males with late-onset hypogonadism
Late-onset hypogonadism (LOH) is a pathological disorder that develops in males over the age of 40 and is diagnosed upon strict criteria that requires that the individual have total serum testosterone (T) below the normal limits as well as three symptoms of sexual dysfunction. Recommended therapy …
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Hypogonadism, Testosterone Replacement Therapy and Risk of Depression in Middle Aged and Older Men in the US
Hypogonadism is posited as a risk factor for depression. Limited evidence from randomized controlled trials (RCTs) suggests that testosterone replacement therapy (TRT) may improve depressive symptoms in hypogonadal men. However, evidence from real world, population-based studies is lacking. …
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Longitudinal study to assess the prevalence of hypogonadism in HIV-infected South African men and its association with bone density, body composition, metabolic abnormalities (dysglycaemia, dyslipidaemia) and quality of life.
Background: Hypogonadism has been described in association with HIV infection and anti-retroviral therapy (ART). Furthermore, hypogonadism is associated with comorbidity and a reduced quality of life. The prevalence of hypogonadism in HIVinfected South African men is unknown. We examined the …
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The Effects of VO2max on Levels of Testosterone as Males Age
… of Testosterone secretion by the gonads is “hypogonadism” and development of age-related hypogonadism is known as “late-onset hypogonadism”. Late-onset hypogonadism is characterized by issues such as osteoporosis, Alzheimer’s disease, frailty, obesity, cardiac failure and ischemic heart …
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Testicular cancer; gonadal, sexual and psychological aspects of the disease and its treatment.
… In article II, risk factors for developing hypogonadism were studied. SCT and RT treated were at higher risk of hypogonadism, 6 and 12 months post-treatment as compared to those who received 1 to 2 cycles of chemotherapy. Microlithiasis and hormone deficiency prior to treatment predicted …
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The clinical characteristics, presentation, and treatment outcomes of prolactinomas at Groote Schuur Hospital
… had at least one hormonal abnormality with hypogonadism 73.1% (n=19) being most common, followed by hypothyroidism 53.8% (n=14) and hypoadrenalism 30% (n=8). Over 50% of patients with a giant adenoma had panhypopituitarism with hypogonadism in 100%, hypothyroidism in 77.8% (n=7) and …
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The association between testosterone and muscle mass, muscle strength, and physical function in Korean men aged 60 and older
… strength and physical performance by gait speed. Hypogonadism was defined by serum testosterone level of less than 350ng/dL. Muscle mass was calculated with appendicular skeletal muscle (ASM) by height square or weight. RESULTS: Serum testosterone had significant relationship with muscle mass (ASM …
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Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila
… features of the KS phenotype are anosmia and hypogonadism. Despite high conservation of the Kal-1 gene from invertebrates to vertebrates, the Kal-1 homolog in mice has not been identified. The unavailability of an animal model has hampered research on the disease in vivo. Hence, little is …
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Molecular and Cellular Investigations of Prader-Willi Syndrome
… resulting in hypotonia, developmental delay, hypogonadism, sleep dysfunction and childhood onset obesity affecting 1 in 10,000 to 30,000 individuals. PWS is an imprinting disorder that is caused by a loss of expression of maternally imprinted genes in the 15q11.2-q13 region including NDN, …
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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
… including normosmic congenital hypogonadotropic hypogonadism (nCHH) and Kallmann syndrome (KS). DNA from a cohort of European nCHH/KS patients was exome sequenced. Mutations in GPCR genes were identified and two hypothalamic GPCRs of interest were identified; oxytocin receptor (OXTR) and Y4 …
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Testosterone might be influenced by co-morbidities, not by aging
… than normal population. Odds ratio of the hypogonadism in chronic disease group compared to normal group was 1.595(95% CI, 1.355-1.876, P<0.001). CONCLUSION: The total testosterone level was lower in chronic disease group compared to healthy subjects. Total testosterone level influenced by …
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The Fanconi anemia pathway and HELQ work alongside dormant replication origins to suppress replication-associated genome instability
… as interstrand crosslink hypersensitivity and hypogonadism, but not defects in homologous recombination repair. Rather, HELQ was found to work in parallel to the FA protein FANCC to suppress replication-associated genome instability.
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Non-coding RNA genes lost in Prader-Willi Syndrome stabilize target RNAs
… developmental delay, intellectual disability, hypogonadism, and excessive appetite. The disease is caused by a de novo genetic deletion in chromosome 15. While many of the deleted genes have been identified, there is little known about their molecular function. There is evidence that a cluster …
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Psycho-endocrinological aspects in aging males and transsexual persons
… the effects of drastic induction of overt hypogonadism followed by cross-sex hormonal substitution in transsexual persons.In the first study (Chapter 5) the regulatory role of oestrogens and androgens on haemoglobin and the haematocrit in transsexual persons undergoing cross hormone …
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The hypothalamic-pituitary-testicular axis: studies on delayed puberty and infertility
… delayed puberty and hypogonadotrophic hypogonadism. The pubertal development of testicular functions was more closely related to the progressive increase in amplitude rather than frequency of pulsatile LH secretion. The roles of FSH and prolactin were less obvious. Exogenous GnRHinduced …
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The Role of the Nhlh2 Protein in Regulating Male Fertility and Sexual Development
… mice (N2KO) show obesity, infertility, and hypogonadism. Likewise, humans with variants in the NHLH2 protein are infertile and hypogonadal with adult-onset obesity. Furthermore, the newly published Dog10K sequencing database uncovered a Nhlh2 variant in the obesity-prone breed Lhasa Apso. To …
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Autophagy maintains the homeostatic environment in the male reproductive organs playing a key role in fertility
… Atg5 knockout (KO) mouse models, which show hypogonadism, leading to a reduced level of testosterone. However, our model showed no changes in serum testosterone levels. Despite this, we found gross cellular changes in the epididymis and evidence of fibrosis following autophagy inhibition. …
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… sensory deficits, and hypogonadotropic hypogonadism. Despite CHD7 mutations being the major cause, the broad clinical variability observed among patients suggests the involvement of genetic modifiers. Recent evidence highlights the Semaphorin (SEMA) signalling pathway as a candidate …
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Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies
Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, …