Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Hypoglycaemia"”.
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Recurrent Hypoglycaemia-examining Impact and Strategy
Hypoglycaemia and fear of hypoglycaemia is considered one of the greatest barriers to patients optimising their metabolic control in Type 1 Diabetes (T1D). Recurrent hypoglycaemia (RH) leads to diminished symptomatic and hormonal (blunted counterregulatory) responses to further hypoglycaemia, which …
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Post-alcoholic hypoglycaemia: a clinical and pathological study
… present was a low cerebrospinal sugar. Hypoglycaemia was suspected and blood sugar estimation confirmed it. Further investigation failed to reveal the cause of the hypoglycaemia and in some cases because of a "flat" glucose tolerance curve organic hyperinsulinism was suspected. In one …
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Prediction and Detection of Hypoglycaemia in Type 1 Diabetes
… still suffer from recurrent and troublesome hypoglycaemia despite improvements in glucose monitoring, insulin delivery and structured education. The key objectives of my thesis were to explore ways to identify patients at greater risk to develop hypoglycaemia and to investigate novel ways to …
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Childhood outcomes in children at risk of neonatal hypoglycaemia
… outcomes of children born at risk of neonatal hypoglycaemia, a common condition that may be associated with adverse neurodevelopmental outcome; (2) investigate methods used for data collection in paediatric longitudinal studies; and (3) determine the relationships between glycaemic response to …
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Hypoglycaemia in type 1 diabetes: risk factors, symptoms and recovery
Hypoglycaemia is the commonest side-effect of insulin treatment for diabetes mellitus. Appreciation of the risk factors for hypoglycaemia and early recognition of its symptoms can help the affected individual with prompt self-treatment of hypoglycaemia, preventing progression to severe …
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The molecular, hormonal and symptomatic responses to hypoglycaemia in mice
… and symptomatic responses to acute and recurrent hypoglycaemia. To test this hypothesis, I used hyperinsulinaemic clamps to create carefully controlled experimental manipulations of blood glucose. It is well established that the hypothalamus plays a fundamental role in glucose sensing and …
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Mid-childhood Outcomes of Children Born at Risk of Neonatal Hypoglycaemia
Background: Neonatal hypoglycaemia is a common and readily treatable risk factor for neurologic impairment in children. Although associations between prolonged symptomatic neonatal hypoglycaemia and brain injury are well established, the effect of asymptomatic transitional hypoglycaemia on …
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Impaired awareness of hypoglycaemia in type 1 diabetes. Prevalence, genetic predisposition and mortality
Contains fulltext : 183427.pdf (Publisher’s version ) (Open Access)
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Childhood Outcomes after Dextrose Gel for Treating and Preventing Low Glucose Levels in Babies
… gel effectively treats and prevents neonatal hypoglycaemia, but its long-term benefits and harms remain unclear. This thesis aimed to investigate childhood outcomes after oral dextrose gel to treat and prevent neonatal hypoglycaemia in late preterm and term at-risk infants. We updated two …
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The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
Hypoglycaemia is the major complication associated with insulin therapy in type 1 diabetes. Repeated exposure to hypoglycaemia leads to suppression of normal counter regulatory responses (CRR) to subsequent hypoglycaemia, which increases the risk of severe episodes of hypoglycaemia. Studies have …
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Biochemical changes in athletes during marathon and ultra-marathon races, with special reference to the incidence and prevention of hypoglycaemia
… is due either to muscle glycogen depletion or to hypoglycaemia secondary to liver glycogen depletion. I therefore undertook three studies to determine the roles of hypoglycaemia in explaining fatigue in marathon and ultra-marathon runners.
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A cross-sectional analysis of the short-term outcomes of patients receiving prehospital treatment for symptomatic hypoglycaemia in Cape Town
Includes abstract. Includes bibliographical references.
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Type 1 diabetes mellitus and the brain: influence of clinical complications and genetic factors on brain structure and cognitive function
… chronic hyperglycaemia and intermittent hypoglycaemia consequent upon treatment with insulin. Severe hypoglycaemia, defined as hypoglycaemia sufficient to necessitate third party intervention for recovery, commonly complicates insulin therapy and repeated exposure may be detrimental to …
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The prevention of adverse neurodevelopmental outcomes in children born to diabetic mothers
… gel one hour after birth to prevent neonatal hypoglycaemia improved neurodevelopment in early childhood. In a prospective cohort study of infants born to mothers with diabetes, glycaemic control in pregnancy was not associated with the children’s neurodevelopment at four and half years of age. …
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The metabolic sequelae of oesophago-gastric resection
… cancer, in particular post-prandial hypoglycaemia, altered appetite, early satiety and noxious post-prandial symptoms. By profiling and challenging the gut hormone axis in healthy volunteers and patients who had undergone total or subtotal gastrectomy, or oesophagectomy, this thesis …
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Glycaemic control in pregnancies complicated by type 1 diabetes
… glucose control and significantly less hypoglycaemia than sensor-augmented pump therapy. Chapter 4 examines women’s experiences of using the closed-loop system during pregnancy. While the system was generally well-received by participants, individual interactions and perceptions of the …
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Investigation of KATP channel function in response to metabolic and pharmacological manipulation, in the hypothalamic GT1-7 cell line
… have consistently demonstrated that recurrent hypoglycaemia (RH) blunts both hormonal and behavioral counter regulatory responses (CRR) to further episodes of hypoglycaemia. It is now well established that the brain is involved in regulating whole-body glucose homeostasis, including the CRR to …
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Non-invasive detection of hyperglycaemia in type 1 diabetic patients using electrocardiographic signals
… observations of ECG changes have been found in hypoglycaemia and hyperglycaemia states in T1DM, such as increased heart rate and prolongation of QT interval in hypoglycaemia, whereas hyperglycaemia was related to reduced heart rate variability. By using these findings in hypoglycaemia, …
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Closed-loop insulin delivery in adults with type 1 diabetes
… Aggressive regimens carry an increased risk of hypoglycaemia, particularly overnight. Both alcohol consumption and exercise predispose further to low glucose levels. The demands are even greater in pregnancy where, in addition to limiting hypoglycaemia, avoidance of postprandial hyperglycaemia …
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Identifying key nodes in brain neural circuits controlling glucose homeostasis
… by changes in blood glucose, from a drop (hypoglycaemia) to a rise (hyperglycaemia) in glucose levels. Here, I combined two powerful contemporary techniques, glucose clamps and tissue clearing, to (1) precisely manipulate blood glucose levels causing brain activation, and (2) subsequently …
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