Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Hypochlorous acid"”.
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Hypochlorous Acid Mediated Damage of Chromatin
<p>Hypochlorous acid (HOCl), the primary product of activated neutrophils at sites of inflammation, can damage both DNA and associated histone proteins. HOCl damage to cytosine bases in DNA generates the chlorination damage products 5-chlorocytosine (ClC) and 5-chlorouracil (ClU) as well as the …
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Destruction of biological tetrapyrrole macrocycles by hypochlorous acid and its scavenging by lycopene
<p>Hypochlorous acid (HOCl) is a potent oxidant generated by the hemoprotein myeloperoxidase. Although HOCl plays an important role in the innate immune response,sustained high levels of HOCl has been implicated to play a harmful role. In several pathological conditions such as atherosclerosis, …
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XANTHENE AND SILICON ANALOGS OF XANTHENE FLUOROPHORES AS CHEMICAL SENSORS FOR pH AND HYPOCHLOROUS ACID
… focuses on the detection of two analytes, H+ and hypochlorous acid, which are of interest in biology because the presence of abnormal quantities of these analytes may be indicative of disease. We have established a new platform for which sensitive changes in various regions of pH can be detected …
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Molecular Probes for Biologically Important Molecules: A Study of Thiourea, Hydroxyl radical, Peroxynitrite and Hypochlorous acid
… and peroxynitrite readily react with amino acids containing aromatic side chains. Low density lipoprotein (LDL) carries cholesterol in the human body. Elevated concentration of LDL is a potential risk factor for atherosclerosis. Previous research drew a strong correlation between oxidized …
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The Inactivation Kinetics of Cryptosporidium Parvum in Sequential Disinfection Treatment Strategies Using Ozone, Hypochlorous Acid and Monochloramine
… these experiments provided evidence that ozone, hypochlorous acid and monochloramine react with similar constituents in the oocyst wall. However, only ozone pretreatment resulted in rates of secondary inactivation enhancement that appear to be limited by a mass transfer process.
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Aging Assessment of High Voltage Single Component Room Temperature Vulcanized Silicone Rubber (RTV-1) Subjected to Aqueous Salt
… environmental aging conditions such as UV, acid, and salt exposure from ocean mist. Loss of hydrophobicity due to damage of the hydrophobic methyl groups, as well as loss of mechanical strength due to depolymerization via hydrolysis as a result of aqueous salt exposure were the two main …
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The Effect of Chlorine and Chloramines on the Viability and Activity of Nitrifying Bacteria
… with sequential treatments of monochloramine and hypochlorous acid to mimic the disinfectant switch employed by drinking water utilities. Indicators of activity (specific nitrite generation rate) and viability (LIVE/DEAD® BacLight© membrane-integrity based assay) were measured to determine …
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The development of appropriate brine electrolysers for disinfection of rural water supplies
… not successful, since sodium hypochlorite and hypochlorous acid interfere using the analytical method described in this study.
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Neutrophil extracellular traps in periodontitis
… a regulatory role for myeloperoxidase generated hypochlorous acid in NET production. In conclusion, the results contained within this thesis indicate a putative role for NETs in the pathogenesis of periodontitis and highlight a high prevalence of potential counter-NET mechanisms in certain …
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The inactivation of Coxsackievirus B5 with monochloramine for safe global water
… has been achieved using disinfectants such as hypochlorous acid or free chlorine. However, Coxsackievirus serotype B5 has demonstrated unique resistance to free chlorine disinfection compared to similar viral pathogens of concern, such as Adenovirus. Due to emerging regulations targeting …
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Human S100A8 and S100A9 Scavenge Pro-inflammatory Hypohalous Acids in Disease
… in chronic inflammatory disorders. Hypohalous acids generated by activated phagocytes are scavenged by murine S100A8 and S100A9, suggesting a protective role in oxidative stress, but effects on human recombinant S100A8 and S100A9 are undefined. Hypohalous acids at low molar ratios (1:1) …
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Chlorinated Tyrosine Species as Markers of Inflammation: A Kinetic Study
… which generates reactive oxygen species such as hypochlorous acid (HOCl). Additionally, MPO generates reactive nitrogen species. These reactive species can damage host fats, proteins, and DNA, contributing to disease pathology. Because of the reactivity and short half-lives of reactive species, …
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The Impact Of Myeloperoxidase And Its Related Oxidants On Metaphase Ii Mouse Oocyte Quality
… peroxide (H2O2), hydroxyl radical (•OH), and hypochlorous acid (HOCl), as well as, the pro-inflammatory enzyme myeloperoxidase (MPO). Previously, it has been shown that these ROS have deleterious effect on oocytes; however the link between inflammation through macrophage activity and oocyte …
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SYNTHESIS AND DEVELOPMENT OF SILICON ANALOG OF FLUORESCEIN FLUOROPHORES AND ESTERIFICATION CATALYSTS
… developed and studied. SIF HySOx is probe for hypochlorous acid (HOCl), which is a reactive oxygen species (ROS) found in cells that are stressed due to various diseases. The HOCl probe was synthesized and its photo-physical properties were studied. It was found to be selective and sensitive …
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The role of oxygen free radicals in the endotoxic shock induced myocardial dysfunction and cellular injury
… production of oxygen free radicals (OFRs) and hypochlorous acid (HOCl). During ET-shock, OFRs could also be produced from other sources including auto-oxidation of catecholamines, xanthine-xanthine oxidase enzyme system during ischemia, and arachidonic acid metabolism. An increase in the levels …
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A systematic study of enzyme-nanomaterial interactions for application in active surface decontamination
… under user-controlled conditions through strong acids treatment and characterized in terms of structure and morphology. A comparison of how the characteristics of both the nanosupports used as well as immobilization technique employed affect retained activity in an enzyme specific manner is also …
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Development of a small-scale electro-chlorination system for rural water supplies
To address the urgent need for safe potable water in South Africa’s rural areas, sustainable systems for water disinfection at the village-scale of operation are required.In this thesis, the development of a small-scale water chlorination system that runs on salt and solar panels is described. The …