Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 377 for “"Hypertrophy"”.
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Metabolic support in left ventricular hypertrophy
Aims: To examine the metabolic changes associated with LVH secondary to AS, to examine the role of GIK as an adjunct to myocardial protection during AVR, and to examine the mechanism of its action. Methods: 220 patients with LVH secondary to AS were randomised 1:1 to receive an infusion of GIK at …
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Compensatory renal hypertrophy, mitochondria and redox status
… undergoes compensatory growth due primarily to hypertrophy, in which both the size and functional capacity of the remaining kidney are increased. Renal compensatory hypertrophy is associated with a series of physiological, morphological and biochemical changes that also have toxicological …
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Insulin -Like Growth Factors Regulate Cardiac Hypertrophy
… IGF-I or IGF-I receptor antibodies also lead to hypertrophy of adult cardiomyocytes. This induction appears to be mediated by the local production of IGF-II, that this growth factor then stimulates the hypertrophy via an IGF-I receptor-independent, IGF-II-responsive pathway that likely involves …
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FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
Stress-induced cardiac hypertrophy is a hallmark feature of pathological remodeling which, left unchecked, predisposes hearts to arrhythmia and failure. FHL2 is a member of the four-and-a-half LIM domain (FHL) family of proteins expressed predominantly in the heart. Targeted disruption of FHL2 …
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Identification and Characterization of MicroRNAs Modulating Cardiac Hypertrophy
… stimuli; in most cases, a phase of compensated hypertrophy evolves into frank dysfunction and heart failure. To identify microRNAs able to prevent cardiac hypertrophy and preserve cardiac function, we performed a high-content microscopy, high-throughput functional screening for human microRNAs …
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Genes with Physiological Roles in Callipyge Muscle Hypertrophy
… and/or RTL1 results in extreme postnatal muscle hypertrophy in loin and hindquarters. DLK1 and/or RTL1 are the primary inducers of muscle hypertrophy due to the inheritance model for the callipyge phenotype. The overall aim of this dissertation is to study the physiological pathways responding to …
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Characterization Of Pregnancy Induced Cardiac Hypertrophy In Rats
… for fetal development, resulting in cardiac hypertrophy. For the majority of women, this physiological cardiac hypertrophy resolves following pregnancy. Prolonged cardiac hypertrophy can lead to heart failure. We propose that by studying the biochemical mechanisms that mediate healthy cardiac …
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Molecular Mechanisms of Growth Hormone Induced Muscle Hypertrophy
The objective of these studies were three fold; (1) to determine the response of different aged rats to a growth hormone secreting tumor, (2) examine the presence and significance of extrahepatic insulin-like growth factor I (IGF-I) and IGF-II mRNA in rats bearing GH$\sb{3}$ tumors, and (3) …
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The Role of STIM1 in Hypertrophy-Related Contractile Dysfunction
… results in remodeling of heart structure by hypertrophy and alterations in the molecular regulation of contractile performance. These adaptations can be regulated by various Ca2+-dependent signaling processes. STIM1 is an important regulator of Ca2+ signaling in different cell types by …
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Mechanisms Regulating Resistance Training Mediated Hypertrophy in Human Skeletal Muscle
… that resistance training induces muscle hypertrophy, although the mechanisms and influence of biological sex are unclear. The extent of post-exercise myofibrillar protein synthesis (MyoPS), satellite cells (SC) and dietary amino acids to promote muscle hypertrophy have generally been …
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Regulation Of The Tubulin Code In Cardiac Hypertrophy And Failure
… network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the “tubulin code” – the permutations of tubulin isoforms and post-translational …
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Caspase-dependent Signaling as an Inductive Cue for Cardiac Hypertrophy
… myocardium enlargement, referred to as cardiac hypertrophy, is a common form of stress adaptation. Divergent forms of hypertrophy can occur depending on the type and duration of the insult. The beneficial physiological form of hypertrophy is reversible and leads to improved cardiac function, …
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Altering Muscle Hypertrophy and Fat Accumulation in Myostatin Null Mice
Myostatin is a negative regulator of muscle growth. Loss of myostatin function results in a dramatic phenotype in several species including cattle, mice, dogs and humans. Myostatin mutants exhibit wide-spread hypermuscularity and decreased fat accumulation. Though the phenotype of myostatin mutant …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… as a critical feature of load-induced cardiac hypertrophy.
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Molecular Basis of Sex Differences in Cardiac Hypertrophy and Heart Failure
… to contribute to the development of cardiac hypertrophy and heart failure. It is well established that premenopausal females possess a lower incidence of these pathologies. We and others have observed a greater level of fibrosis in male hearts compared to female hearts in rodent models of …
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Dapagliflozin Regresses Left Ventricular Hypertrophy in People with Type 2 Diabetes
… this benefit is regression of left ventricular hypertrophy (LVH); an independent predictor of cardiovascular events including incident heart failure.<br/><br/>We tested the hypothesis that dapagliflozin may regress LVH in people with T2D.<br/><br/>We randomly assigned 66 people (mean age 67 +/- …
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